The NLRP6 Inflammasome Recognizes Lipoteichoic Acid and Regulates Gram-Positive Pathogen Infection

The activator and composition of the NLRP6 inflammasome remain poorly understood. We find that lipoteichoic acid (LTA), a molecule produced by Gram-positive bacteria, binds and activates NLRP6. In response to cytosolic LTA or infection with Listeria monocytogenes, NLRP6 recruited caspase-11 and casp...

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Veröffentlicht in:	Cell 2018-11, Vol.175 (6), p.1651-1664.e14
Hauptverfasser:	Hara, Hideki, Seregin, Sergey S., Yang, Dahai, Fukase, Koichi, Chamaillard, Mathias, Alnemri, Emad S., Inohara, Naohiro, Chen, Grace Y., Núñez, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Caspase 1 - genetics Caspase 1 - immunology caspase-1 caspase-11 Caspases - genetics Caspases - immunology gram-positive bacteria IL-18 Immunity, Innate inflammasome Inflammasomes - genetics Inflammasomes - immunology Interleukin-18 - genetics Interleukin-18 - immunology Interleukin-1beta - genetics Interleukin-1beta - immunology Life Sciences Lipopolysaccharides - immunology lipoteichoic acid Listeria monocytogenes Listeria monocytogenes - immunology Listeriosis - genetics Listeriosis - immunology Listeriosis - pathology Mice Mice, Knockout NLRP6 Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Teichoic Acids - immunology
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