More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription
The IκB kinase (IKK) complex is best known as the core regulator of NF‐κB signalling. Recent work from Mikuda et al reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK...
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| description | The IκB kinase (IKK) complex is best known as the core regulator of NF‐κB signalling. Recent work from Mikuda
et al
reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P‐body formation and the stability of numerous mRNAs, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.
Graphical Abstract
A new study finds IKKβ to control mRNA decapping, illustrating how cellular signalling shapes gene expression via both mRNA synthesis and degradation. |
| doi_str_mv | 10.15252/embj.2018101084 |
| format | Article |
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reveals a new and unexpected function for IKK in the regulation of mRNA stability. Through interacting with and phosphorylating EDC4, a key component of the mRNA decapping complex, IKK regulates P‐body formation and the stability of numerous mRNAs, including many encoding inflammatory cytokines. Activation of IKK can therefore be more generally thought of as programming the cellular response to stress and infection through both mRNA stability and transcription.
Graphical Abstract
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Graphical Abstract
A new study finds IKKβ to control mRNA decapping, illustrating how cellular signalling shapes gene expression via both mRNA synthesis and degradation.</description><subject>Cytokines</subject><subject>EMBO19</subject><subject>EMBO36</subject><subject>EMBO37</subject><subject>Goats</subject><subject>I-kappa B Kinase</subject><subject>Inflammation</subject><subject>mRNA stability</subject><subject>News & Views</subject><subject>Phosphorylation</subject><subject>RNA Stability</subject><subject>Stability</subject><subject>Transcription</subject><subject>Views</subject><issn>0261-4189</issn><issn>1460-2075</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUctu1DAUtRCIDoU9K2SJDZsUPxMbIaS2KjC0BQnBioXlODeth8Qe7ASYX-Mj-CYMU1qKhFjdxXnonHsQuk_JHpVMsscwtqs9RqiihBIlbqAFFTWpGGnkTbQgrKaVoErvoDs5rwghUjX0NtrhRBKtG7JAH05jAjyd24BXc55wucvv3w7wRx9shicFAbw8PsYujusBvpYbU1ewCTIe377ex3myrR_8tCnSDk_JhuySX08-hrvoVm-HDPcu7i56__zo3eHL6uTNi-Xh_knlJNWiYqWIkpSRVnFnO0VBqF67rqecOu60q0HynlnRAUjdS8KbUoRraKUD2QLfRc-2vuu5HaFzEEqMwayTH23amGi9uY4Ef27O4mdTM81ZI4rBowuDFD_NkCcz-uxgGGyAOGfDqNCKC6FkoT78i7qKcwqlXmFJWbOmvLawyJblUsw5QX8ZhhLzaznzczlztVyRPPizxKXg91SF8HRL-OIH2PzX0BydHry65k-38lyU4QzSVfB_ZvoBh0W2nA</recordid><startdate>20181214</startdate><enddate>20181214</enddate><creator>Perkins, Neil D</creator><general>Nature Publishing Group UK</general><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9756-3656</orcidid></search><sort><creationdate>20181214</creationdate><title>More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription</title><author>Perkins, Neil D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5194-225285120b83cad81e48f9cdf131c3c9c6e53f2a4dee59f503700539eb5ce5be3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cytokines</topic><topic>EMBO19</topic><topic>EMBO36</topic><topic>EMBO37</topic><topic>Goats</topic><topic>I-kappa B Kinase</topic><topic>Inflammation</topic><topic>mRNA stability</topic><topic>News & Views</topic><topic>Phosphorylation</topic><topic>RNA Stability</topic><topic>Stability</topic><topic>Transcription</topic><topic>Views</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Perkins, Neil D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>The EMBO journal</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>Perkins, Neil D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription</atitle><jtitle>The EMBO journal</jtitle><stitle>EMBO J</stitle><addtitle>EMBO J</addtitle><date>2018-12-14</date><risdate>2018</risdate><volume>37</volume><issue>24</issue><epage>n/a</epage><issn>0261-4189</issn><eissn>1460-2075</eissn><abstract>The IκB kinase (IKK) complex is best known as the core regulator of NF‐κB signalling. Recent work from Mikuda
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Graphical Abstract
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| language | eng |
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| source | Springer Nature OA Free Journals |
| subjects | Cytokines EMBO19 EMBO36 EMBO37 Goats I-kappa B Kinase Inflammation mRNA stability News & Views Phosphorylation RNA Stability Stability Transcription Views |
| title | More than just an IκB kinase: the IKK complex coordinates mRNA stability and transcription |
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