Schizophrenia-Like Dopamine Release Abnormalities in a Mouse Model of NMDA Receptor Hypofunction

Abstract Amphetamine-induced augmentation of striatal dopamine and its blunted release in prefrontal cortex (PFC) is a hallmark of schizophrenia pathophysiology. Although N-methyl-D-aspartate receptor (NMDAR) hypofunction is also implicated in schizophrenia, it remains unclear whether NMDAR hypofunc...

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Veröffentlicht in:	Schizophrenia bulletin 2019-01, Vol.45 (1), p.138-147
Hauptverfasser:	Nakao, Kazuhito, Jeevakumar, Vivek, Jiang, Sunny Zhihong, Fujita, Yuko, Diaz, Noelia B, Pretell Annan, Carlos A, Eskow Jaunarajs, Karen L, Hashimoto, Kenji, Belforte, Juan E, Nakazawa, Kazu
Format:	Artikel
Sprache:	eng
Schlagworte:	Amphetamine - pharmacology Animals Behavior, Animal - drug effects Behavior, Animal - physiology Central Nervous System Stimulants - pharmacology Disease Models, Animal Dopamine - metabolism GABAergic Neurons - metabolism Mice Mice, Knockout Nerve Tissue Proteins - genetics Nerve Tissue Proteins - metabolism Nucleus Accumbens - drug effects Nucleus Accumbens - metabolism Prefrontal Cortex - drug effects Prefrontal Cortex - metabolism Receptors, N-Methyl-D-Aspartate - genetics Receptors, N-Methyl-D-Aspartate - metabolism Regular Schizophrenia - metabolism
Online-Zugang:	Volltext
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