Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen
Purpose To examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data. Methods Forty-four eyes (24 eyes o...
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| Veröffentlicht in: | Eye (London) 2018-12, Vol.32 (12), p.1819-1830 |
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| creator | Pfau, Maximilian Lindner, Moritz Gliem, Martin Steinberg, Julia S. Thiele, Sarah Finger, Robert P. Fleckenstein, Monika Holz, Frank G. Schmitz-Valckenberg, Steffen |
| description | Purpose
To examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data.
Methods
Forty-four eyes (24 eyes of 24 patients with drusen, age 69.4 ± 12.6 years; 20 normal eyes of 16 subjects, 61.7 ± 12.4 years) underwent duplicate mesopic, dark-adapted cyan and dark-adapted red FCP within 14° of the central retina (total of 12 936 threshold tests) using the Scotopic Macular Integrity Assessment (S-MAIA, CenterVue, Padova, Italy) device. FCP data were registered to SD-OCT data to obtain outer nuclear layer, inner and outer photoreceptor segment, and retinal pigment epithelium drusen complex (RPEDC) thickness data spatially corresponding to the stimulus location and area (0.43°). Structure-function correlations were assessed using mixed-effects models.
Results
Mean deviation values for eyes with cuticular, soft, and reticular drusen were similar for mesopic (−2.1, −3.4, and −3.6 dB) and dark-adapted red (−1.4, −2.6, and −3.3 dB) FCP. For the dark-adapted cyan FCP (0.1, −1.9, and −5.0 dB) and for the cyan–red sensitivity difference (+1.0, +0.5, and −2.4 dB), the mean deviation values differed significantly in dependence of the predominant drusen type (one-way ANOVA;
p
|
| doi_str_mv | 10.1038/s41433-018-0183-3 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6292882</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2082090230</sourcerecordid><originalsourceid>FETCH-LOGICAL-c470t-e6da64f1ef2203c85a54a90d383031f6da58a38d8056cbd96867c39bbcf28a453</originalsourceid><addsrcrecordid>eNp1UV1rFDEUDaLY7eoP8EUCvvhg9CaZzGReBClaCy19UfAtZJNMmzqbjPmw9N-bZetaBR8uSTjnnntuDkIvKLylwOW73NGOcwJU7ooT_gitaDf0RHSie4xWMAogjLFvR-g45xuABg7wFB1xgF6OTK5QvXA5Lt5gHSy2On0n2uqlOIvLbSQmzjHhqQZbc3uEkuI8N2xxyW9dSXfYB7zo4l0oGd_6co1NLd7UWac3OLnDdaee41SwTTW78Aw9mfSc3fP7c42-fvr45eQzOb88PTv5cE5MN0Ahrre67ybqJsaAGym06PQIlksOnE4NFVJzaSWI3mzs2Mt-MHzcbMzEpO4EX6P3e92lbrbOmmYz6Vktzb1Odypqr_5Ggr9WV_Gn6ln7HcmawOt7gRR_VJeL2vps3Dzr4GLNioFkMAJrftbo1T_Um1hTaOspRoWQY9McGovuWSbFnJObDmYoqF2oah-qaoHuiiveel4-3OLQ8TvFRmB7Qm5QuHLpz-j_q_4CMSivZQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2155896297</pqid></control><display><type>article</type><title>Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen</title><source>PubMed Central(OpenAccess)</source><source>EZB-FREE-00999 freely available EZB journals</source><source>Alma/SFX Local Collection</source><creator>Pfau, Maximilian ; Lindner, Moritz ; Gliem, Martin ; Steinberg, Julia S. ; Thiele, Sarah ; Finger, Robert P. ; Fleckenstein, Monika ; Holz, Frank G. ; Schmitz-Valckenberg, Steffen</creator><creatorcontrib>Pfau, Maximilian ; Lindner, Moritz ; Gliem, Martin ; Steinberg, Julia S. ; Thiele, Sarah ; Finger, Robert P. ; Fleckenstein, Monika ; Holz, Frank G. ; Schmitz-Valckenberg, Steffen</creatorcontrib><description>Purpose
To examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data.
Methods
Forty-four eyes (24 eyes of 24 patients with drusen, age 69.4 ± 12.6 years; 20 normal eyes of 16 subjects, 61.7 ± 12.4 years) underwent duplicate mesopic, dark-adapted cyan and dark-adapted red FCP within 14° of the central retina (total of 12 936 threshold tests) using the Scotopic Macular Integrity Assessment (S-MAIA, CenterVue, Padova, Italy) device. FCP data were registered to SD-OCT data to obtain outer nuclear layer, inner and outer photoreceptor segment, and retinal pigment epithelium drusen complex (RPEDC) thickness data spatially corresponding to the stimulus location and area (0.43°). Structure-function correlations were assessed using mixed-effects models.
Results
Mean deviation values for eyes with cuticular, soft, and reticular drusen were similar for mesopic (−2.1, −3.4, and −3.6 dB) and dark-adapted red (−1.4, −2.6, and −3.3 dB) FCP. For the dark-adapted cyan FCP (0.1, −1.9, and −5.0 dB) and for the cyan–red sensitivity difference (+1.0, +0.5, and −2.4 dB), the mean deviation values differed significantly in dependence of the predominant drusen type (one-way ANOVA;
p
< 0.05). RPEDC thickness was associated with reduction of mesopic sensitivity (−0.34 dB/10 µm RPEDC thickening;
p
< 0.001), dark-adapted cyan sensitivity (−0.11 dB/10 µm RPEDC thickening;
p
= 0.003), and dark-adapted red sensitivity (−0.26 dB/10 µm RPEDC thickening;
p
< 0.001).
Conclusions
In contrast to mesopic FCP, dark-adapted two-color FCP allowed for meaningful differential testing of rod and cone function in patients with drusen indicating predominant cone dysfunction in eyes with cuticular drusen and predominant rod dysfunction in eyes with reticular drusen. RPEDC thickness was the strongest predictor of the evaluated SD-OCT biomarkers for point-wise sensitivity.</description><identifier>ISSN: 0950-222X</identifier><identifier>EISSN: 1476-5454</identifier><identifier>DOI: 10.1038/s41433-018-0183-3</identifier><identifier>PMID: 30068928</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>692/308/53/2422 ; 692/699/3161/3175 ; Animal models ; Color vision ; Epithelium ; Eye ; Laboratory Medicine ; Medicine ; Medicine & Public Health ; Ophthalmology ; Pharmaceutical Sciences/Technology ; Retina ; Retinal pigment epithelium ; Structure-function relationships ; Surgery ; Surgical Oncology</subject><ispartof>Eye (London), 2018-12, Vol.32 (12), p.1819-1830</ispartof><rights>The Royal College of Ophthalmologists 2018</rights><rights>Copyright Nature Publishing Group Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c470t-e6da64f1ef2203c85a54a90d383031f6da58a38d8056cbd96867c39bbcf28a453</citedby><cites>FETCH-LOGICAL-c470t-e6da64f1ef2203c85a54a90d383031f6da58a38d8056cbd96867c39bbcf28a453</cites><orcidid>0000-0002-4416-3421</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292882/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6292882/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30068928$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pfau, Maximilian</creatorcontrib><creatorcontrib>Lindner, Moritz</creatorcontrib><creatorcontrib>Gliem, Martin</creatorcontrib><creatorcontrib>Steinberg, Julia S.</creatorcontrib><creatorcontrib>Thiele, Sarah</creatorcontrib><creatorcontrib>Finger, Robert P.</creatorcontrib><creatorcontrib>Fleckenstein, Monika</creatorcontrib><creatorcontrib>Holz, Frank G.</creatorcontrib><creatorcontrib>Schmitz-Valckenberg, Steffen</creatorcontrib><title>Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen</title><title>Eye (London)</title><addtitle>Eye</addtitle><addtitle>Eye (Lond)</addtitle><description>Purpose
To examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data.
Methods
Forty-four eyes (24 eyes of 24 patients with drusen, age 69.4 ± 12.6 years; 20 normal eyes of 16 subjects, 61.7 ± 12.4 years) underwent duplicate mesopic, dark-adapted cyan and dark-adapted red FCP within 14° of the central retina (total of 12 936 threshold tests) using the Scotopic Macular Integrity Assessment (S-MAIA, CenterVue, Padova, Italy) device. FCP data were registered to SD-OCT data to obtain outer nuclear layer, inner and outer photoreceptor segment, and retinal pigment epithelium drusen complex (RPEDC) thickness data spatially corresponding to the stimulus location and area (0.43°). Structure-function correlations were assessed using mixed-effects models.
Results
Mean deviation values for eyes with cuticular, soft, and reticular drusen were similar for mesopic (−2.1, −3.4, and −3.6 dB) and dark-adapted red (−1.4, −2.6, and −3.3 dB) FCP. For the dark-adapted cyan FCP (0.1, −1.9, and −5.0 dB) and for the cyan–red sensitivity difference (+1.0, +0.5, and −2.4 dB), the mean deviation values differed significantly in dependence of the predominant drusen type (one-way ANOVA;
p
< 0.05). RPEDC thickness was associated with reduction of mesopic sensitivity (−0.34 dB/10 µm RPEDC thickening;
p
< 0.001), dark-adapted cyan sensitivity (−0.11 dB/10 µm RPEDC thickening;
p
= 0.003), and dark-adapted red sensitivity (−0.26 dB/10 µm RPEDC thickening;
p
< 0.001).
Conclusions
In contrast to mesopic FCP, dark-adapted two-color FCP allowed for meaningful differential testing of rod and cone function in patients with drusen indicating predominant cone dysfunction in eyes with cuticular drusen and predominant rod dysfunction in eyes with reticular drusen. RPEDC thickness was the strongest predictor of the evaluated SD-OCT biomarkers for point-wise sensitivity.</description><subject>692/308/53/2422</subject><subject>692/699/3161/3175</subject><subject>Animal models</subject><subject>Color vision</subject><subject>Epithelium</subject><subject>Eye</subject><subject>Laboratory Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Ophthalmology</subject><subject>Pharmaceutical Sciences/Technology</subject><subject>Retina</subject><subject>Retinal pigment epithelium</subject><subject>Structure-function relationships</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>0950-222X</issn><issn>1476-5454</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNp1UV1rFDEUDaLY7eoP8EUCvvhg9CaZzGReBClaCy19UfAtZJNMmzqbjPmw9N-bZetaBR8uSTjnnntuDkIvKLylwOW73NGOcwJU7ooT_gitaDf0RHSie4xWMAogjLFvR-g45xuABg7wFB1xgF6OTK5QvXA5Lt5gHSy2On0n2uqlOIvLbSQmzjHhqQZbc3uEkuI8N2xxyW9dSXfYB7zo4l0oGd_6co1NLd7UWac3OLnDdaee41SwTTW78Aw9mfSc3fP7c42-fvr45eQzOb88PTv5cE5MN0Ahrre67ybqJsaAGym06PQIlksOnE4NFVJzaSWI3mzs2Mt-MHzcbMzEpO4EX6P3e92lbrbOmmYz6Vktzb1Odypqr_5Ggr9WV_Gn6ln7HcmawOt7gRR_VJeL2vps3Dzr4GLNioFkMAJrftbo1T_Um1hTaOspRoWQY9McGovuWSbFnJObDmYoqF2oah-qaoHuiiveel4-3OLQ8TvFRmB7Qm5QuHLpz-j_q_4CMSivZQ</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Pfau, Maximilian</creator><creator>Lindner, Moritz</creator><creator>Gliem, Martin</creator><creator>Steinberg, Julia S.</creator><creator>Thiele, Sarah</creator><creator>Finger, Robert P.</creator><creator>Fleckenstein, Monika</creator><creator>Holz, Frank G.</creator><creator>Schmitz-Valckenberg, Steffen</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TK</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-4416-3421</orcidid></search><sort><creationdate>20181201</creationdate><title>Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen</title><author>Pfau, Maximilian ; Lindner, Moritz ; Gliem, Martin ; Steinberg, Julia S. ; Thiele, Sarah ; Finger, Robert P. ; Fleckenstein, Monika ; Holz, Frank G. ; Schmitz-Valckenberg, Steffen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c470t-e6da64f1ef2203c85a54a90d383031f6da58a38d8056cbd96867c39bbcf28a453</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>692/308/53/2422</topic><topic>692/699/3161/3175</topic><topic>Animal models</topic><topic>Color vision</topic><topic>Epithelium</topic><topic>Eye</topic><topic>Laboratory Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Ophthalmology</topic><topic>Pharmaceutical Sciences/Technology</topic><topic>Retina</topic><topic>Retinal pigment epithelium</topic><topic>Structure-function relationships</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pfau, Maximilian</creatorcontrib><creatorcontrib>Lindner, Moritz</creatorcontrib><creatorcontrib>Gliem, Martin</creatorcontrib><creatorcontrib>Steinberg, Julia S.</creatorcontrib><creatorcontrib>Thiele, Sarah</creatorcontrib><creatorcontrib>Finger, Robert P.</creatorcontrib><creatorcontrib>Fleckenstein, Monika</creatorcontrib><creatorcontrib>Holz, Frank G.</creatorcontrib><creatorcontrib>Schmitz-Valckenberg, Steffen</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health and Medical</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>ProQuest Biological Science Journals</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Eye (London)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pfau, Maximilian</au><au>Lindner, Moritz</au><au>Gliem, Martin</au><au>Steinberg, Julia S.</au><au>Thiele, Sarah</au><au>Finger, Robert P.</au><au>Fleckenstein, Monika</au><au>Holz, Frank G.</au><au>Schmitz-Valckenberg, Steffen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen</atitle><jtitle>Eye (London)</jtitle><stitle>Eye</stitle><addtitle>Eye (Lond)</addtitle><date>2018-12-01</date><risdate>2018</risdate><volume>32</volume><issue>12</issue><spage>1819</spage><epage>1830</epage><pages>1819-1830</pages><issn>0950-222X</issn><eissn>1476-5454</eissn><abstract>Purpose
To examine the feasibility and utility of dark-adapted two-color fundus-controlled perimetry (FCP) in patients with cuticular, reticular, and soft drusen, and to compare FCP data to microstructural spectral-domain optical coherence tomography (SD-OCT) data.
Methods
Forty-four eyes (24 eyes of 24 patients with drusen, age 69.4 ± 12.6 years; 20 normal eyes of 16 subjects, 61.7 ± 12.4 years) underwent duplicate mesopic, dark-adapted cyan and dark-adapted red FCP within 14° of the central retina (total of 12 936 threshold tests) using the Scotopic Macular Integrity Assessment (S-MAIA, CenterVue, Padova, Italy) device. FCP data were registered to SD-OCT data to obtain outer nuclear layer, inner and outer photoreceptor segment, and retinal pigment epithelium drusen complex (RPEDC) thickness data spatially corresponding to the stimulus location and area (0.43°). Structure-function correlations were assessed using mixed-effects models.
Results
Mean deviation values for eyes with cuticular, soft, and reticular drusen were similar for mesopic (−2.1, −3.4, and −3.6 dB) and dark-adapted red (−1.4, −2.6, and −3.3 dB) FCP. For the dark-adapted cyan FCP (0.1, −1.9, and −5.0 dB) and for the cyan–red sensitivity difference (+1.0, +0.5, and −2.4 dB), the mean deviation values differed significantly in dependence of the predominant drusen type (one-way ANOVA;
p
< 0.05). RPEDC thickness was associated with reduction of mesopic sensitivity (−0.34 dB/10 µm RPEDC thickening;
p
< 0.001), dark-adapted cyan sensitivity (−0.11 dB/10 µm RPEDC thickening;
p
= 0.003), and dark-adapted red sensitivity (−0.26 dB/10 µm RPEDC thickening;
p
< 0.001).
Conclusions
In contrast to mesopic FCP, dark-adapted two-color FCP allowed for meaningful differential testing of rod and cone function in patients with drusen indicating predominant cone dysfunction in eyes with cuticular drusen and predominant rod dysfunction in eyes with reticular drusen. RPEDC thickness was the strongest predictor of the evaluated SD-OCT biomarkers for point-wise sensitivity.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30068928</pmid><doi>10.1038/s41433-018-0183-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-4416-3421</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Eye (London), 2018-12, Vol.32 (12), p.1819-1830 |
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| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6292882 |
| source | PubMed Central(OpenAccess); EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 692/308/53/2422 692/699/3161/3175 Animal models Color vision Epithelium Eye Laboratory Medicine Medicine Medicine & Public Health Ophthalmology Pharmaceutical Sciences/Technology Retina Retinal pigment epithelium Structure-function relationships Surgery Surgical Oncology |
| title | Mesopic and dark-adapted two-color fundus-controlled perimetry in patients with cuticular, reticular, and soft drusen |
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