TBX18 overexpression enhances pacemaker function in a rat subsidiary atrial pacemaker model of sick sinus syndrome

Key points The sinoatrial node (SAN) is the primary pacemaker of the heart. SAN dysfunction, or ‘sick sinus syndrome’, can cause excessively slow heart rates and pauses, leading to exercise limitation and syncope, currently treated by implantation of an electronic pacemaker. ‘Biopacemaking’ utilises...

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Veröffentlicht in:	The Journal of physiology 2018-12, Vol.596 (24), p.6141-6155
Hauptverfasser:	Choudhury, M., Black, N., Alghamdi, A., D'Souza, A., Wang, R., Yanni, J., Dobrzynski, H., Kingston, P. A., Zhang, H., Boyett, M. R., Morris, G. M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals biopacemaking Bradycardia Calcium Cardiovascular Computer Simulation Coronary artery disease Electrophysiology Gene expression Gene Expression Regulation gene therapy Heart Atria Heart Conduction System - metabolism Heart diseases Heart rate Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - genetics Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels - metabolism Ion channels (cyclic nucleotide-gated) Male Models, Biological Na+/Ca2+ exchanger NCX1 protein Pacemakers Protein Isoforms - genetics Protein Isoforms - metabolism Rats Research Paper sick sinus syndrome Sick Sinus Syndrome - therapy Sinoatrial Node - physiology Sodium-Calcium Exchanger - metabolism Standard deviation subsidiary atrial pacemaker tissue Syncope T-Box Domain Proteins - genetics T-Box Domain Proteins - metabolism TBX18 Tissue Culture Techniques Transcription factors
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