Association Between the Oligomeric Status of p53 and Clinical Outcomes in Li-Fraumeni Syndrome

Li-Fraumeni syndrome (LFS) is a rare hereditary cancer disorder with highly variable clinical outcomes that results from germline mutations in the TP53 gene. Here we report that the quaternary structure of p53 is an important factor affecting cellular functions and the clinical outcomes of LFS patie...

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Veröffentlicht in:	JNCI : Journal of the National Cancer Institute 2018-12, Vol.110 (12), p.1418-1421
Hauptverfasser:	Fischer, Nicholas W, Prodeus, Aaron, Tran, James, Malkin, David, Gariépy, Jean
Format:	Artikel
Sprache:	eng
Schlagworte:	Brief Communication Genetic Association Studies Genetic Predisposition to Disease Germ-Line Mutation Humans Li-Fraumeni Syndrome - genetics Li-Fraumeni Syndrome - mortality Models, Molecular Mutation Prognosis Protein Conformation Protein Multimerization Structure-Activity Relationship Survival Analysis Tumor Suppressor Protein p53 - chemistry Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
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