Assessing the respective contributions of dietary flavanol monomers and procyanidins in mediating cardiovascular effects in humans: randomized, controlled, double-masked intervention trial

Flavanols are an important class of food bioactives that can improve vascular function even in healthy subjects. Cocoa flavanols (CFs) are composed principally of the monomer (−)-epicatechin (∼20%), with a degree of polymerisation (DP) of 1 (DP1), and oligomeric procyanidins (∼80%, DP2–10). Our obje...

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Veröffentlicht in:	The American journal of clinical nutrition 2018-12, Vol.108 (6), p.1229-1237
Hauptverfasser:	Rodriguez-Mateos, Ana, Weber, Timon, Skene, Simon S, Ottaviani, Javier I, Crozier, Alan, Kelm, Malte, Schroeter, Hagen, Heiss, Christian
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult bioactive compounds Blood pressure Blood Pressure - drug effects Cacao - chemistry Cardiovascular disease Cardiovascular Physiological Phenomena - drug effects Catabolites Catechin - administration & dosage Catechin - blood Catechin - pharmacokinetics Cholesterol Cholesterol - blood Circulatory system Clinical trials Cocoa Degree of polymerization Diet digestive system Double-Blind Method endothelial function Endothelium Endothelium, Vascular - drug effects Endothelium, Vascular - physiology Epicatechin epicatechin: procyanidins Flavanols Flavonols - administration & dosage Humans Intervention Intestinal microflora Male men Metabolites Microbiomes Monomers nutritional intervention Original Research Communications Plant Extracts - chemistry Polymerization Proanthocyanidins - administration & dosage Procyanidins Randomization structurally related (−)-epicatechin metabolites valerolactones Vasodilation volunteers Wave velocity Young Adult
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