Design, formulation and evaluation of novel dissolving microarray patches containing a long-acting rilpivirine nanosuspension

One means of combating the spread of human immunodeficiency virus (HIV) is through the delivery of long-acting, antiretroviral (ARV) drugs for prevention and treatment. The development of a discreet, self-administered and self-disabling delivery vehicle to deliver such ARV drugs could obviate compli...

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Veröffentlicht in:	Journal of controlled release 2018-12, Vol.292, p.119-129
Hauptverfasser:	Mc Crudden, Maelíosa T.C., Larrañeta, Eneko, Clark, Annie, Jarrahian, Courtney, Rein-Weston, Annie, Lachau-Durand, Sophie, Niemeijer, Nico, Williams, Peter, Haeck, Clement, McCarthy, Helen O., Zehrung, Darin, Donnelly, Ryan F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Cutaneous Animals Anti-HIV Agents - administration & dosage Anti-HIV Agents - pharmacokinetics Antiretroviral antiretroviral agents clinical trials compliance disease transmission Drug Compounding Drug Delivery Systems drugs Female health services HIV HIV Infections - prevention & control Human immunodeficiency virus humans in vivo studies lymph nodes Lymph Nodes - metabolism Microarray patch microarray technology Microinjections Nanostructures - administration & dosage patients Polymers - administration & dosage rats Rats, Sprague-Dawley Rilpivirine Rilpivirine - administration & dosage Rilpivirine - pharmacokinetics Skin - metabolism Solubility Swine Vagina - metabolism
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