Endogenous IL-10 maintains immune tolerance but IL-10 gene transfer exacerbates autoimmune cholangitis

The immunomodulatory effect of IL-10 as an immunosuppressive and anti-inflammatory cytokine is well known. Taking advantage of our established mouse model of autoimmune cholangitis using 2-octynoic acid conjugated ovalbumin (2-OA-OVA) induction, we compared liver pathology, immune cell populations a...

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Veröffentlicht in:	Journal of autoimmunity 2018-12, Vol.95, p.159-170
Hauptverfasser:	Hsueh, Yu-Hsin, Chen, Hung-Wen, Syu, Bi-Jhen, Lin, Chia-I., Leung, Patrick S.C., Gershwin, M. Eric, Chuang, Ya-Hui
Format:	Artikel
Sprache:	eng
Schlagworte:	Adeno-associated virus IFN-γ IL-10 Inflammation Liver autoimmune disease
Online-Zugang:	Volltext
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