A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity

The immune system ensures optimum T-effector (Teff) immune responses against invading microbes and tumor antigens while preventing inappropriate autoimmune responses against self-antigens with the help of T-regulatory (Treg) cells. Thus, Treg and Teff cells help maintain immune homeostasis through m...

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Veröffentlicht in:	Journal of autoimmunity 2018-12, Vol.95, p.77-99
Hauptverfasser:	Kumar, Prabhakaran, Bhattacharya, Palash, Prabhakar, Bellur S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antineoplastic Agents, Immunological - therapeutic use Autoimmunity B7-H1 Antigen - genetics B7-H1 Antigen - immunology Cancer Co-inhibitory receptors Co-stimulatory receptors CTLA-4 Antigen - genetics CTLA-4 Antigen - immunology Gene Expression Regulation Glucocorticoid-Induced TNFR-Related Protein - genetics Glucocorticoid-Induced TNFR-Related Protein - immunology Homeostasis - immunology Humans Mice Neoplasms - drug therapy Neoplasms - genetics Neoplasms - immunology Neoplasms - pathology Programmed Cell Death 1 Receptor - genetics Programmed Cell Death 1 Receptor - immunology Receptors, OX40 - genetics Receptors, OX40 - immunology Signal Transduction - immunology T-Lymphocytes, Cytotoxic - immunology T-Lymphocytes, Regulatory - immunology Tregs Tumor Escape Tumor Necrosis Factor Receptor Superfamily, Member 9 - genetics Tumor Necrosis Factor Receptor Superfamily, Member 9 - immunology
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