Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress
OBJECTIVES:The current laboratory study quantified blood oxidative stress to woodsmoke exposure. METHODS:Participants inhaled woodsmoke during three randomized crossover exercise trials (Clean Air [0 μg/m], Low Exposure [250 μg/m], and High Exposure [500 μg/m], Woodsmoke [particulate matter less tha...
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| Veröffentlicht in: | Journal of occupational and environmental medicine 2018-12, Vol.60 (12), p.1073-1081 |
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| container_title | Journal of occupational and environmental medicine |
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| creator | Peters, Bridget Ballmann, Christopher Quindry, Tiffany Zehner, Emily G McCroskey, Justin Ferguson, Matthew Ward, Tony Dumke, Charles Quindry, John C |
| description | OBJECTIVES:The current laboratory study quantified blood oxidative stress to woodsmoke exposure.
METHODS:Participants inhaled woodsmoke during three randomized crossover exercise trials (Clean Air [0 μg/m], Low Exposure [250 μg/m], and High Exposure [500 μg/m], Woodsmoke [particulate matter less than 2.5 μm, PM2.5]). Trolox equivalent antioxidant capacity (TEAC), uric acid (UA), 8-isoprostanes (8-ISO), lipid hydroperoxides (LOOH), protein carbonyls (PC), nitrotyrosine (3-NT), 8-isoprostane, and myeloperoxidase (MPO) were quantified in Pre, immediately Post, and 1- (1Hr) hour post blood samples.
RESULTS:UA decreased following Low Exposure, while plasma TEAC levels increased Post and 1Hr. LOOH levels decreased 1Hr Post (High Exposure), while 8-Iso increased following both smoke trials. PC and MPO were unchanged following all trials, while 3-NT increased over Clean Air.
CONCLUSION:Blood oxidative stress occurred largely independent of PM2.5 concentrations. Future studies should employ longer duration smoke and exercise combined with physiologic parameters. |
| doi_str_mv | 10.1097/JOM.0000000000001437 |
| format | Article |
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METHODS:Participants inhaled woodsmoke during three randomized crossover exercise trials (Clean Air [0 μg/m], Low Exposure [250 μg/m], and High Exposure [500 μg/m], Woodsmoke [particulate matter less than 2.5 μm, PM2.5]). Trolox equivalent antioxidant capacity (TEAC), uric acid (UA), 8-isoprostanes (8-ISO), lipid hydroperoxides (LOOH), protein carbonyls (PC), nitrotyrosine (3-NT), 8-isoprostane, and myeloperoxidase (MPO) were quantified in Pre, immediately Post, and 1- (1Hr) hour post blood samples.
RESULTS:UA decreased following Low Exposure, while plasma TEAC levels increased Post and 1Hr. LOOH levels decreased 1Hr Post (High Exposure), while 8-Iso increased following both smoke trials. PC and MPO were unchanged following all trials, while 3-NT increased over Clean Air.
CONCLUSION:Blood oxidative stress occurred largely independent of PM2.5 concentrations. Future studies should employ longer duration smoke and exercise combined with physiologic parameters.</description><identifier>ISSN: 1076-2752</identifier><identifier>EISSN: 1536-5948</identifier><identifier>DOI: 10.1097/JOM.0000000000001437</identifier><identifier>PMID: 30188494</identifier><language>eng</language><publisher>United States: Copyright by the American College of Occupational and Environmental Medicine</publisher><subject>Antioxidants ; Blood ; Carbonyl compounds ; Carbonyls ; Chemical compounds ; Clinical trials ; Crossovers ; Exercise physiology ; Exposure ; Isoprostanes ; Lipid peroxidation ; Lipids ; Nitrotyrosine ; Oxidation ; Oxidative stress ; Particulate matter ; Peroxidase ; Proteins ; Smoke ; Uric acid ; Vitamin E</subject><ispartof>Journal of occupational and environmental medicine, 2018-12, Vol.60 (12), p.1073-1081</ispartof><rights>Copyright © 2018 by the American College of Occupational and Environmental Medicine</rights><rights>Copyright Lippincott Williams & Wilkins Ovid Technologies Dec 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4857-7c8534faa7e5fbf971def330c11c8243d2c9d444de872d163adc1a7b08f5cf153</citedby><cites>FETCH-LOGICAL-c4857-7c8534faa7e5fbf971def330c11c8243d2c9d444de872d163adc1a7b08f5cf153</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30188494$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Peters, Bridget</creatorcontrib><creatorcontrib>Ballmann, Christopher</creatorcontrib><creatorcontrib>Quindry, Tiffany</creatorcontrib><creatorcontrib>Zehner, Emily G</creatorcontrib><creatorcontrib>McCroskey, Justin</creatorcontrib><creatorcontrib>Ferguson, Matthew</creatorcontrib><creatorcontrib>Ward, Tony</creatorcontrib><creatorcontrib>Dumke, Charles</creatorcontrib><creatorcontrib>Quindry, John C</creatorcontrib><title>Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress</title><title>Journal of occupational and environmental medicine</title><addtitle>J Occup Environ Med</addtitle><description>OBJECTIVES:The current laboratory study quantified blood oxidative stress to woodsmoke exposure.
METHODS:Participants inhaled woodsmoke during three randomized crossover exercise trials (Clean Air [0 μg/m], Low Exposure [250 μg/m], and High Exposure [500 μg/m], Woodsmoke [particulate matter less than 2.5 μm, PM2.5]). Trolox equivalent antioxidant capacity (TEAC), uric acid (UA), 8-isoprostanes (8-ISO), lipid hydroperoxides (LOOH), protein carbonyls (PC), nitrotyrosine (3-NT), 8-isoprostane, and myeloperoxidase (MPO) were quantified in Pre, immediately Post, and 1- (1Hr) hour post blood samples.
RESULTS:UA decreased following Low Exposure, while plasma TEAC levels increased Post and 1Hr. LOOH levels decreased 1Hr Post (High Exposure), while 8-Iso increased following both smoke trials. PC and MPO were unchanged following all trials, while 3-NT increased over Clean Air.
CONCLUSION:Blood oxidative stress occurred largely independent of PM2.5 concentrations. Future studies should employ longer duration smoke and exercise combined with physiologic parameters.</description><subject>Antioxidants</subject><subject>Blood</subject><subject>Carbonyl compounds</subject><subject>Carbonyls</subject><subject>Chemical compounds</subject><subject>Clinical trials</subject><subject>Crossovers</subject><subject>Exercise physiology</subject><subject>Exposure</subject><subject>Isoprostanes</subject><subject>Lipid peroxidation</subject><subject>Lipids</subject><subject>Nitrotyrosine</subject><subject>Oxidation</subject><subject>Oxidative stress</subject><subject>Particulate matter</subject><subject>Peroxidase</subject><subject>Proteins</subject><subject>Smoke</subject><subject>Uric acid</subject><subject>Vitamin E</subject><issn>1076-2752</issn><issn>1536-5948</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kUtP3DAUha2qVaGUf1BVkbphE_AzdjaVCoUWBJpFW7G0PPYNE_DEg53w-Pe9aCiiLPDGr-8e3XMPIZ8Y3WW01Xsns7Nd-mwxKfQbssmUaGrVSvMWz1Q3NdeKb5APpVwioxhV78mGoMwY2cpNcnJ4t4LcL2EYXazOUwplma6gwudUpgzV9yn3wwXeIfu-QOWGUO1H5KrZXR_c2N9A9WvMUMpH8q5zscD2475F_hwd_j74WZ_OfhwffDutvTRK19obJWTnnAbVzbtWswCdENQz5g2XInDfBillAKN5YI1wwTOn59R0yndob4t8XeuupvkSgsfWs4t2hS5cvrfJ9fb_n6Ff2It0YxtuWs0bFNh5FMjpeoIy2mVfPMToBkhTsZxRKriWXCP65QV6maY8oD2kGhwmDvGBkmvK51RKhu6pGUbtQ1gWw7Ivw8Kyz8-NPBX9SwcBswZuUxwhl6s43UK2C3BxXLyu_RfJg6F6</recordid><startdate>201812</startdate><enddate>201812</enddate><creator>Peters, Bridget</creator><creator>Ballmann, Christopher</creator><creator>Quindry, Tiffany</creator><creator>Zehner, Emily G</creator><creator>McCroskey, Justin</creator><creator>Ferguson, Matthew</creator><creator>Ward, Tony</creator><creator>Dumke, Charles</creator><creator>Quindry, John C</creator><general>Copyright by the American College of Occupational and Environmental Medicine</general><general>Lippincott Williams & Wilkins Ovid Technologies</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U7</scope><scope>7U9</scope><scope>C1K</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>201812</creationdate><title>Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress</title><author>Peters, Bridget ; Ballmann, Christopher ; Quindry, Tiffany ; Zehner, Emily G ; McCroskey, Justin ; Ferguson, Matthew ; Ward, Tony ; Dumke, Charles ; Quindry, John C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4857-7c8534faa7e5fbf971def330c11c8243d2c9d444de872d163adc1a7b08f5cf153</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Antioxidants</topic><topic>Blood</topic><topic>Carbonyl compounds</topic><topic>Carbonyls</topic><topic>Chemical compounds</topic><topic>Clinical trials</topic><topic>Crossovers</topic><topic>Exercise physiology</topic><topic>Exposure</topic><topic>Isoprostanes</topic><topic>Lipid peroxidation</topic><topic>Lipids</topic><topic>Nitrotyrosine</topic><topic>Oxidation</topic><topic>Oxidative stress</topic><topic>Particulate matter</topic><topic>Peroxidase</topic><topic>Proteins</topic><topic>Smoke</topic><topic>Uric acid</topic><topic>Vitamin E</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peters, Bridget</creatorcontrib><creatorcontrib>Ballmann, Christopher</creatorcontrib><creatorcontrib>Quindry, Tiffany</creatorcontrib><creatorcontrib>Zehner, Emily G</creatorcontrib><creatorcontrib>McCroskey, Justin</creatorcontrib><creatorcontrib>Ferguson, Matthew</creatorcontrib><creatorcontrib>Ward, Tony</creatorcontrib><creatorcontrib>Dumke, Charles</creatorcontrib><creatorcontrib>Quindry, John C</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Health and Safety Science Abstracts (Full archive)</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of occupational and environmental medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peters, Bridget</au><au>Ballmann, Christopher</au><au>Quindry, Tiffany</au><au>Zehner, Emily G</au><au>McCroskey, Justin</au><au>Ferguson, Matthew</au><au>Ward, Tony</au><au>Dumke, Charles</au><au>Quindry, John C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress</atitle><jtitle>Journal of occupational and environmental medicine</jtitle><addtitle>J Occup Environ Med</addtitle><date>2018-12</date><risdate>2018</risdate><volume>60</volume><issue>12</issue><spage>1073</spage><epage>1081</epage><pages>1073-1081</pages><issn>1076-2752</issn><eissn>1536-5948</eissn><abstract>OBJECTIVES:The current laboratory study quantified blood oxidative stress to woodsmoke exposure.
METHODS:Participants inhaled woodsmoke during three randomized crossover exercise trials (Clean Air [0 μg/m], Low Exposure [250 μg/m], and High Exposure [500 μg/m], Woodsmoke [particulate matter less than 2.5 μm, PM2.5]). Trolox equivalent antioxidant capacity (TEAC), uric acid (UA), 8-isoprostanes (8-ISO), lipid hydroperoxides (LOOH), protein carbonyls (PC), nitrotyrosine (3-NT), 8-isoprostane, and myeloperoxidase (MPO) were quantified in Pre, immediately Post, and 1- (1Hr) hour post blood samples.
RESULTS:UA decreased following Low Exposure, while plasma TEAC levels increased Post and 1Hr. LOOH levels decreased 1Hr Post (High Exposure), while 8-Iso increased following both smoke trials. PC and MPO were unchanged following all trials, while 3-NT increased over Clean Air.
CONCLUSION:Blood oxidative stress occurred largely independent of PM2.5 concentrations. Future studies should employ longer duration smoke and exercise combined with physiologic parameters.</abstract><cop>United States</cop><pub>Copyright by the American College of Occupational and Environmental Medicine</pub><pmid>30188494</pmid><doi>10.1097/JOM.0000000000001437</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of occupational and environmental medicine, 2018-12, Vol.60 (12), p.1073-1081 |
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| source | Jstor Complete Legacy; Journals@Ovid Complete |
| subjects | Antioxidants Blood Carbonyl compounds Carbonyls Chemical compounds Clinical trials Crossovers Exercise physiology Exposure Isoprostanes Lipid peroxidation Lipids Nitrotyrosine Oxidation Oxidative stress Particulate matter Peroxidase Proteins Smoke Uric acid Vitamin E |
| title | Experimental Woodsmoke Exposure During Exercise and Blood Oxidative Stress |
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