EGFR-targeting, β-defensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis

Defensins play an essential role in innate immunity. In this study, a novel recombinant β-defensin that targets the epidermal growth factor receptor (EGFR) was designed and prepared. The EGFR-targeting β-defensin consists of an EGF-derived oligopeptide (Ec), a β-defensin-1 peptide (hBD1) and a lidam...

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Veröffentlicht in:	Acta pharmacologica Sinica 2018-11, Vol.39 (11), p.1777-1786
Hauptverfasser:	Liu, Wen-Juan, Liu, Xiu-Jun, Xu, Jian, Li, Liang, Li, Yi, Zhang, Sheng-Hua, Wang, Jia-Lin, Miao, Qing-Fang, Zhen, Yong-Su
Format:	Artikel
Sprache:	eng
Schlagworte:	Aminoglycosides - metabolism Aminoglycosides - therapeutic use Animals Antineoplastic Agents - metabolism Antineoplastic Agents - therapeutic use Apoproteins - metabolism Apoproteins - therapeutic use Apoptosis Apoptosis - drug effects beta-Defensins - metabolism beta-Defensins - therapeutic use Biomedical and Life Sciences Biomedicine Body weight Cancer Carcinoma, Squamous Cell - drug therapy Cell Line, Tumor Cell proliferation Cytotoxicity Defensins Enediynes - metabolism Enediynes - therapeutic use Epidermal growth factor Epidermal growth factor receptors ErbB Receptors - metabolism Female Fusion protein Humans Immunology Innate immunity Internal Medicine Localization Lung cancer Lung carcinoma Medical Microbiology Mice Mice, Nude Mitochondria Mitochondria - metabolism Mitochondria - pathology Pharmacology/Toxicology Protein Binding Recombinant Fusion Proteins - metabolism Recombinant Fusion Proteins - therapeutic use Vaccine Xenograft Model Antitumor Assays Xenografts
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