The oncoprotein HBXIP promotes human breast cancer growth through down-regulating p53 via miR-18b/MDM2 and pAKT/MDM2 pathways

Mammalian hepatitis B X-interacting protein (HBXIP) is an 18-kDa protein that regulates a large number of transcription factors such as TF-IID, E2F1, SP1, STAT3, c-Myc, and LXR by serving as an oncogenic transcription coactivator and plays an important role in the development of breast cancer. We pr...

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Veröffentlicht in:	Acta pharmacologica Sinica 2018-11, Vol.39 (11), p.1787-1796
Hauptverfasser:	Li, Hang, Wang, Zhen, Jiang, Mian, Fang, Run-ping, Shi, Hui, Shen, Yu, Cai, Xiao-li, Liu, Qian, Ye, Kai, Fan, Sai-jun, Zhang, Wei-ying, Ye, Li-hong
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - metabolism Animals Biomedical and Life Sciences Biomedicine Breast cancer Breast Neoplasms - metabolism c-Myc protein Cell Line, Tumor DNA methylation Down-Regulation Female Gene Expression Regulation, Neoplastic Health risk assessment Hepatitis Hepatitis B Humans Immunology Internal Medicine MDM2 protein Medical Microbiology Mice, Inbred BALB C MicroRNAs - genetics MicroRNAs - metabolism Molecular modelling Myc protein Oncogene Proteins - metabolism Oncoproteins p53 Protein Pharmacology/Toxicology Phosphorylation Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-mdm2 - genetics Proto-Oncogene Proteins c-mdm2 - metabolism Signal Transduction - physiology Sp1 protein Stat3 protein Transcription factors Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Up-Regulation Vaccine Xenografts
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