Dynamics of PAR Proteins Explain the Oscillation and Ratcheting Mechanisms in Dorsal Closure

We present a vertex-based model for Drosophila dorsal closure that predicts the mechanics of cell oscillation and contraction from the dynamics of the PAR proteins. Based on experimental observations of how aPKC, Par-6, and Bazooka translocate from the circumference of the apical surface to the medi...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biophysical journal 2018-12, Vol.115 (11), p.2230-2241
Hauptverfasser:	Durney, Clinton H., Harris, Tony J.C., Feng, James J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Actomyosin - metabolism Animals Cell Biophysics Cell Polarity Drosophila melanogaster - embryology Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Embryo, Nonmammalian - cytology Embryo, Nonmammalian - metabolism Embryonic Development Glycogen Synthase Kinase 3 - genetics Glycogen Synthase Kinase 3 - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Protein Kinase C - genetics Protein Kinase C - metabolism Protein Transport
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!