Glucocorticoid receptor regulates expression of microRNA-22 and downstream signaling pathway in apoptosis of pancreatic acinar cells

To elucidate the underlying mechanism that microRNA-22 (miR-22) promotes the apoptosis of rat pancreatic acinar cells (AR42J) and the elements that regulate the expression of miR-22. One hundred nanomoles per liter of caerulein (Cae) was administrated to induce the apoptosis of AR42J cells and the a...

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Veröffentlicht in:	World journal of gastroenterology : WJG 2018-12, Vol.24 (45), p.5120-5130
Hauptverfasser:	Fu, Qiang, Liu, Chuan-Jiang, Zhang, Xu, Zhai, Zhen-Sheng, Wang, Yu-Zhu, Hu, Ming-Xing, Xu, Xian-Ling, Zhang, Hong-Wei, Qin, Tao
Format:	Artikel
Sprache:	eng
Schlagworte:	Acinar Cells - physiology Animals Apoptosis - drug effects Apoptosis - genetics Basic Study Cell Line Ceruletide - pharmacology Down-Regulation MicroRNAs - antagonists & inhibitors MicroRNAs - genetics MicroRNAs - metabolism Pancreas - cytology Rats Receptors, Glucocorticoid - genetics Receptors, Glucocorticoid - metabolism RNA, Small Interfering - metabolism Signal Transduction - genetics Transcription Initiation Site Up-Regulation
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