Parkinson-Associated SNCA Enhancer Variants Revealed by Open Chromatin in Mouse Dopamine Neurons

The progressive loss of midbrain (MB) dopaminergic (DA) neurons defines the motor features of Parkinson disease (PD), and modulation of risk by common variants in PD has been well established through genome-wide association studies (GWASs). We acquired open chromatin signatures of purified embryonic...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	American journal of human genetics 2018-12, Vol.103 (6), p.874-892
Hauptverfasser:	McClymont, Sarah A., Hook, Paul W., Soto, Alexandra I., Reed, Xylena, Law, William D., Kerans, Samuel J., Waite, Eric L., Briceno, Nicole J., Thole, Joey F., Heckman, Michael G., Diehl, Nancy N., Wszolek, Zbigniew K., Moore, Cedric D., Zhu, Heng, Akiyama, Jennifer A., Dickel, Diane E., Visel, Axel, Pennacchio, Len A., Ross, Owen A., Beer, Michael A., McCallion, Andrew S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Alleles alpha-synuclein (SNCA) alpha-Synuclein - genetics Animals ATAC-seq Chromatin - genetics chromatin accessibility Disease Models, Animal dopaminergic neurons Dopaminergic Neurons - pathology enhancer Enhancer Elements, Genetic - genetics Female Genetic Predisposition to Disease - genetics Genotype Humans Introns - genetics Male Mice Mice, Transgenic Middle Aged Parkinson disease Parkinson Disease - genetics Pregnancy regulatory variation Zebrafish
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!