Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function
Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morph...
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| Veröffentlicht in: | Scientific reports 2018-12, Vol.8 (1), p.17757-12, Article 17757 |
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| creator | Cops, Jirka Mullens, Wilfried Verbrugge, Frederik H. Swennen, Quirine De Moor, Bart Reynders, Carmen Penders, Joris Achten, Ruth Driessen, Ann Dendooven, Amélie Rigo, Jean-Michel Hansen, Dominique |
| description | Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p |
| doi_str_mv | 10.1038/s41598-018-36189-3 |
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In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p < 0.0001). Indices of liver and kidney weight, function and morphology, inflammation as well as collagen deposition were significantly increased in the IVCc compared to SHAM group, (p < 0.05). Echocardiographic and hemodynamic parameters were largely unaffected by abdominal venous congestion. In this rat model of isolated abdominal venous congestion, retrogradely conducted glomerular hypertension without a concomitant change in glomerular filtration rate was observed. Adverse short-term hepatic morphological alterations were developed which explain the observed organ function dysfunction. Importantly, cardiac function remained comparable between both groups. This study provides relevant insight in the pathophysiology of abdominal congestion on organ function.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-018-36189-3</identifier><identifier>PMID: 30532057</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>14 ; 14/63 ; 64 ; 692/4020/4021/1607/1605 ; 692/4022/272/1684/1587 ; 82 ; 82/1 ; Abdomen ; Abdomen - physiopathology ; Animals ; Cardiac function ; Cardio-Renal Syndrome - physiopathology ; Collagen ; Collagen - metabolism ; Echocardiography - methods ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Heart - physiopathology ; Heart diseases ; Heart Failure - metabolism ; Heart Failure - physiopathology ; Hemodynamics - physiology ; Humanities and Social Sciences ; Hypertension ; Inflammation - metabolism ; Inflammation - physiopathology ; Kidney - metabolism ; Kidney - physiopathology ; Kidneys ; Liver ; Liver - metabolism ; Liver - physiopathology ; Male ; Morphology ; multidisciplinary ; Rats ; Rats, Sprague-Dawley ; Renal failure ; Renal function ; Rodents ; Science ; Science (multidisciplinary) ; Vena Cava, Inferior - metabolism ; Vena Cava, Inferior - physiopathology</subject><ispartof>Scientific reports, 2018-12, Vol.8 (1), p.17757-12, Article 17757</ispartof><rights>The Author(s) 2018</rights><rights>2018. 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In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p < 0.0001). Indices of liver and kidney weight, function and morphology, inflammation as well as collagen deposition were significantly increased in the IVCc compared to SHAM group, (p < 0.05). Echocardiographic and hemodynamic parameters were largely unaffected by abdominal venous congestion. In this rat model of isolated abdominal venous congestion, retrogradely conducted glomerular hypertension without a concomitant change in glomerular filtration rate was observed. Adverse short-term hepatic morphological alterations were developed which explain the observed organ function dysfunction. Importantly, cardiac function remained comparable between both groups. 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Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Scientific reports</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cops, Jirka</au><au>Mullens, Wilfried</au><au>Verbrugge, Frederik H.</au><au>Swennen, Quirine</au><au>De Moor, Bart</au><au>Reynders, Carmen</au><au>Penders, Joris</au><au>Achten, Ruth</au><au>Driessen, Ann</au><au>Dendooven, Amélie</au><au>Rigo, Jean-Michel</au><au>Hansen, Dominique</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function</atitle><jtitle>Scientific reports</jtitle><stitle>Sci Rep</stitle><addtitle>Sci Rep</addtitle><date>2018-12-10</date><risdate>2018</risdate><volume>8</volume><issue>1</issue><spage>17757</spage><epage>12</epage><pages>17757-12</pages><artnum>17757</artnum><issn>2045-2322</issn><eissn>2045-2322</eissn><abstract>Venous congestion is an important contributor to worsening renal function in heart failure and the cardiorenal syndrome. In patients, it is difficult to study the effects of isolated venous congestion on organ function. In this study, the consequences of isolated abdominal venous congestion on morphology and function of the kidneys, liver and heart were studied in a rat model. Twelve sham-operated (SHAM) male Sprague Dawley rats were compared to eleven inferior vena cava-constricted (IVCc) rats for twenty-one weeks. Abdominal venous pressure was significantly higher in the IVCc versus SHAM group (p < 0.0001). Indices of liver and kidney weight, function and morphology, inflammation as well as collagen deposition were significantly increased in the IVCc compared to SHAM group, (p < 0.05). Echocardiographic and hemodynamic parameters were largely unaffected by abdominal venous congestion. In this rat model of isolated abdominal venous congestion, retrogradely conducted glomerular hypertension without a concomitant change in glomerular filtration rate was observed. Adverse short-term hepatic morphological alterations were developed which explain the observed organ function dysfunction. Importantly, cardiac function remained comparable between both groups. This study provides relevant insight in the pathophysiology of abdominal congestion on organ function.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>30532057</pmid><doi>10.1038/s41598-018-36189-3</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0001-5836-2037</orcidid><orcidid>https://orcid.org/0000-0002-1749-7119</orcidid><orcidid>https://orcid.org/0000-0003-1877-6125</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | 14 14/63 64 692/4020/4021/1607/1605 692/4022/272/1684/1587 82 82/1 Abdomen Abdomen - physiopathology Animals Cardiac function Cardio-Renal Syndrome - physiopathology Collagen Collagen - metabolism Echocardiography - methods Glomerular filtration rate Glomerular Filtration Rate - physiology Heart - physiopathology Heart diseases Heart Failure - metabolism Heart Failure - physiopathology Hemodynamics - physiology Humanities and Social Sciences Hypertension Inflammation - metabolism Inflammation - physiopathology Kidney - metabolism Kidney - physiopathology Kidneys Liver Liver - metabolism Liver - physiopathology Male Morphology multidisciplinary Rats Rats, Sprague-Dawley Renal failure Renal function Rodents Science Science (multidisciplinary) Vena Cava, Inferior - metabolism Vena Cava, Inferior - physiopathology |
| title | Selective abdominal venous congestion induces adverse renal and hepatic morphological and functional alterations despite a preserved cardiac function |
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