Fingolimod reduces neuropathic pain behaviors in a mouse model of multiple sclerosis by a sphingosine-1 phosphate receptor 1-dependent inhibition of central sensitization in the dorsal horn

Multiple sclerosis (MS) is an autoimmune-inflammatory neurodegenerative disease that is often accompanied by a debilitating neuropathic pain. Disease-modifying agents slow down the progression of multiple sclerosis and prevent relapses, yet it remains unclear if they yield analgesia. We explored the...

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Veröffentlicht in:	Pain (Amsterdam) 2018-02, Vol.159 (2), p.224-238
Hauptverfasser:	Doolen, Suzanne, Iannitti, Tommaso, Donahue, Renee R., Shaw, Benjamin C., Grachen, Carolyn M., Taylor, Bradley K.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anilides - pharmacology Animals Central Nervous System Sensitization - drug effects Disease Models, Animal eIF-2 Kinase - metabolism Female Fingolimod Hydrochloride - therapeutic use Immunosuppressive Agents - therapeutic use Male Mice Mice, Inbred C57BL Motor Activity - drug effects Multiple Sclerosis - chemically induced Multiple Sclerosis - complications Multiple Sclerosis - drug therapy Myelin-Oligodendrocyte Glycoprotein - toxicity Neuralgia - drug therapy Neuralgia - etiology Neuralgia - pathology Organophosphonates - pharmacology Oxadiazoles - pharmacology Pain Threshold - drug effects Peptide Fragments - toxicity Receptors, Lysosphingolipid - metabolism Sphingosine-1-Phosphate Receptors Spinal Cord - metabolism Spinal Cord - pathology Spinal Nerve Roots - drug effects Spinal Nerve Roots - metabolism Subcellular Fractions - drug effects Subcellular Fractions - metabolism Thiophenes - pharmacology
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