A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model
Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on pol...
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| Veröffentlicht in: | Biomaterials 2018-11, Vol.182, p.13-20 |
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| creator | Wathier, Michel Lakin, Benjamin A. Cooper, Benjamin G. Bansal, Prashant N. Bendele, Alison M. Entezari, Vahid Suzuki, Hideki Snyder, Brian D. Grinstaff, Mark W. |
| description | Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one®) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control. |
| doi_str_mv | 10.1016/j.biomaterials.2018.08.009 |
| format | Article |
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Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one®) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control.</description><identifier>ISSN: 0142-9612</identifier><identifier>EISSN: 1878-5905</identifier><identifier>DOI: 10.1016/j.biomaterials.2018.08.009</identifier><identifier>PMID: 30099277</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Animals ; biocompatibility ; biolubricants ; Biomechanical Phenomena ; Biomechanics ; Biotribology ; cartilage ; cattle ; Cell Line ; Chondrocytes - cytology ; Chondrocytes - drug effects ; Chondrocytes - metabolism ; Chondroprotection ; friction ; Furans - administration & dosage ; Furans - pharmacology ; Furans - therapeutic use ; Humans ; hyaluronic acid ; hyaluronoglucosaminidase ; Injections, Intra-Articular ; Knee Injuries - drug therapy ; Knee Injuries - metabolism ; Knee Joint - drug effects ; Knee Joint - metabolism ; Lubricants ; lubrication ; Male ; Meniscus - drug effects ; Meniscus - injuries ; Meniscus - metabolism ; Mice ; NIH 3T3 Cells ; Osteoarthritis ; Osteoarthritis - drug therapy ; Poly-oxanorbornane ; Polyenes - administration & dosage ; Polyenes - pharmacology ; Polyenes - therapeutic use ; polymers ; rats ; Rats, Inbred Lew ; synovial fluid ; Synovial Fluid - drug effects ; Synovial Fluid - metabolism ; viscoelasticity ; Viscosupplements - administration & dosage ; Viscosupplements - pharmacology ; Viscosupplements - therapeutic use</subject><ispartof>Biomaterials, 2018-11, Vol.182, p.13-20</ispartof><rights>2018 Elsevier Ltd</rights><rights>Copyright © 2018 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c546t-361e99d92b076accd442141e8e6147e415b192f6807f8808a071c86b82c382833</citedby><cites>FETCH-LOGICAL-c546t-361e99d92b076accd442141e8e6147e415b192f6807f8808a071c86b82c382833</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0142961218305635$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,314,776,780,881,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30099277$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wathier, Michel</creatorcontrib><creatorcontrib>Lakin, Benjamin A.</creatorcontrib><creatorcontrib>Cooper, Benjamin G.</creatorcontrib><creatorcontrib>Bansal, Prashant N.</creatorcontrib><creatorcontrib>Bendele, Alison M.</creatorcontrib><creatorcontrib>Entezari, Vahid</creatorcontrib><creatorcontrib>Suzuki, Hideki</creatorcontrib><creatorcontrib>Snyder, Brian D.</creatorcontrib><creatorcontrib>Grinstaff, Mark W.</creatorcontrib><title>A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model</title><title>Biomaterials</title><addtitle>Biomaterials</addtitle><description>Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one®) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control.</description><subject>Animals</subject><subject>biocompatibility</subject><subject>biolubricants</subject><subject>Biomechanical Phenomena</subject><subject>Biomechanics</subject><subject>Biotribology</subject><subject>cartilage</subject><subject>cattle</subject><subject>Cell Line</subject><subject>Chondrocytes - cytology</subject><subject>Chondrocytes - drug effects</subject><subject>Chondrocytes - metabolism</subject><subject>Chondroprotection</subject><subject>friction</subject><subject>Furans - administration & dosage</subject><subject>Furans - pharmacology</subject><subject>Furans - therapeutic use</subject><subject>Humans</subject><subject>hyaluronic acid</subject><subject>hyaluronoglucosaminidase</subject><subject>Injections, Intra-Articular</subject><subject>Knee Injuries - drug therapy</subject><subject>Knee Injuries - metabolism</subject><subject>Knee Joint - drug effects</subject><subject>Knee Joint - metabolism</subject><subject>Lubricants</subject><subject>lubrication</subject><subject>Male</subject><subject>Meniscus - drug effects</subject><subject>Meniscus - injuries</subject><subject>Meniscus - metabolism</subject><subject>Mice</subject><subject>NIH 3T3 Cells</subject><subject>Osteoarthritis</subject><subject>Osteoarthritis - drug therapy</subject><subject>Poly-oxanorbornane</subject><subject>Polyenes - administration & dosage</subject><subject>Polyenes - pharmacology</subject><subject>Polyenes - therapeutic use</subject><subject>polymers</subject><subject>rats</subject><subject>Rats, Inbred Lew</subject><subject>synovial fluid</subject><subject>Synovial Fluid - drug effects</subject><subject>Synovial Fluid - metabolism</subject><subject>viscoelasticity</subject><subject>Viscosupplements - administration & dosage</subject><subject>Viscosupplements - pharmacology</subject><subject>Viscosupplements - therapeutic use</subject><issn>0142-9612</issn><issn>1878-5905</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNUU2LFDEQDaK44-pfkODJS4-pdCYfHoRl_YQFL3rwFNLpGidDd9ImmYX595th1mW9CVUkIa_eq6pHyBtga2Ag3-3XQ0izq5iDm8qaM9Br1oKZJ2QFWuluY9jmKVkxELwzEvgFeVHKnrU3E_w5uegb1nClVuTXFS3HWHdYg6dLmo5zY_W0CUyHod1crDTMi8u1UL9LccxpyamiryFFGiJ1NLtKZ4yheDfRii7TOY04vSTPtq09fHV_XpKfnz_9uP7a3Xz_8u366qbzGyFr10tAY0bDB6ak834UgoMA1ChBKBSwGcDwrdRMbbVm2jEFXstBc99rrvv-knw48y6HYcbRY6zZTXbJYXb5aJML9t-fGHb2d7q1kmulhGkEb-8JcvpzwFLt3GbBaXIR06FYDj1o2fKk9f4M9TmVknH7IAPMnryxe_vYG3vyxrIW7KTz-nGjD6V_zWiAj2cAtnXdBsy2-IDR4xhyW7gdU_gfnTt3UakK</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Wathier, Michel</creator><creator>Lakin, Benjamin A.</creator><creator>Cooper, Benjamin G.</creator><creator>Bansal, Prashant N.</creator><creator>Bendele, Alison M.</creator><creator>Entezari, Vahid</creator><creator>Suzuki, Hideki</creator><creator>Snyder, Brian D.</creator><creator>Grinstaff, Mark W.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7S9</scope><scope>L.6</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model</title><author>Wathier, Michel ; Lakin, Benjamin A. ; Cooper, Benjamin G. ; Bansal, Prashant N. ; Bendele, Alison M. ; Entezari, Vahid ; Suzuki, Hideki ; Snyder, Brian D. ; Grinstaff, Mark W.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c546t-361e99d92b076accd442141e8e6147e415b192f6807f8808a071c86b82c382833</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Animals</topic><topic>biocompatibility</topic><topic>biolubricants</topic><topic>Biomechanical Phenomena</topic><topic>Biomechanics</topic><topic>Biotribology</topic><topic>cartilage</topic><topic>cattle</topic><topic>Cell Line</topic><topic>Chondrocytes - cytology</topic><topic>Chondrocytes - drug effects</topic><topic>Chondrocytes - metabolism</topic><topic>Chondroprotection</topic><topic>friction</topic><topic>Furans - administration & dosage</topic><topic>Furans - pharmacology</topic><topic>Furans - therapeutic use</topic><topic>Humans</topic><topic>hyaluronic acid</topic><topic>hyaluronoglucosaminidase</topic><topic>Injections, Intra-Articular</topic><topic>Knee Injuries - drug therapy</topic><topic>Knee Injuries - metabolism</topic><topic>Knee Joint - drug effects</topic><topic>Knee Joint - metabolism</topic><topic>Lubricants</topic><topic>lubrication</topic><topic>Male</topic><topic>Meniscus - drug effects</topic><topic>Meniscus - injuries</topic><topic>Meniscus - metabolism</topic><topic>Mice</topic><topic>NIH 3T3 Cells</topic><topic>Osteoarthritis</topic><topic>Osteoarthritis - drug therapy</topic><topic>Poly-oxanorbornane</topic><topic>Polyenes - administration & dosage</topic><topic>Polyenes - pharmacology</topic><topic>Polyenes - therapeutic use</topic><topic>polymers</topic><topic>rats</topic><topic>Rats, Inbred Lew</topic><topic>synovial fluid</topic><topic>Synovial Fluid - drug effects</topic><topic>Synovial Fluid - metabolism</topic><topic>viscoelasticity</topic><topic>Viscosupplements - administration & dosage</topic><topic>Viscosupplements - pharmacology</topic><topic>Viscosupplements - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wathier, Michel</creatorcontrib><creatorcontrib>Lakin, Benjamin A.</creatorcontrib><creatorcontrib>Cooper, Benjamin G.</creatorcontrib><creatorcontrib>Bansal, Prashant N.</creatorcontrib><creatorcontrib>Bendele, Alison M.</creatorcontrib><creatorcontrib>Entezari, Vahid</creatorcontrib><creatorcontrib>Suzuki, Hideki</creatorcontrib><creatorcontrib>Snyder, Brian D.</creatorcontrib><creatorcontrib>Grinstaff, Mark W.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>AGRICOLA</collection><collection>AGRICOLA - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomaterials</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wathier, Michel</au><au>Lakin, Benjamin A.</au><au>Cooper, Benjamin G.</au><au>Bansal, Prashant N.</au><au>Bendele, Alison M.</au><au>Entezari, Vahid</au><au>Suzuki, Hideki</au><au>Snyder, Brian D.</au><au>Grinstaff, Mark W.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model</atitle><jtitle>Biomaterials</jtitle><addtitle>Biomaterials</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>182</volume><spage>13</spage><epage>20</epage><pages>13-20</pages><issn>0142-9612</issn><eissn>1878-5905</eissn><abstract>Intra-articular injection of hyaluronic acid (HA) is used to treat osteoarthritis (OA) as a viscosupplement, yet it only provides short-term benefit because HA is cleaved by hyaluronidase and cleared out of the joint after several days. Therefore, we developed a new polymer biolubricant based on poly-oxanorbornane carboxylate to enhance joint lubrication for a prolonged time. Rheological and biotribological studies of the biolubricant reveal viscoelastic properties and coefficient of friction equivalent and superior to that of healthy synovial fluid, respectively. Furthermore, in an ex vivo bovine cartilage plug model, the biolubricant exhibits superior long-term reduction of friction and wear prevention compared to saline and healthy synovial fluid. ISO 10993 biocompatibility tests demonstrate that the biolubricant polymer is non-toxic. In an in vivo rat medial meniscal tear OA model, where the performance of the leading HA viscosupplement (Synvisc-one®) is comparable to the saline control, treatment with the biolubricant affords significant chondroprotection compared to the saline control.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>30099277</pmid><doi>10.1016/j.biomaterials.2018.08.009</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Animals biocompatibility biolubricants Biomechanical Phenomena Biomechanics Biotribology cartilage cattle Cell Line Chondrocytes - cytology Chondrocytes - drug effects Chondrocytes - metabolism Chondroprotection friction Furans - administration & dosage Furans - pharmacology Furans - therapeutic use Humans hyaluronic acid hyaluronoglucosaminidase Injections, Intra-Articular Knee Injuries - drug therapy Knee Injuries - metabolism Knee Joint - drug effects Knee Joint - metabolism Lubricants lubrication Male Meniscus - drug effects Meniscus - injuries Meniscus - metabolism Mice NIH 3T3 Cells Osteoarthritis Osteoarthritis - drug therapy Poly-oxanorbornane Polyenes - administration & dosage Polyenes - pharmacology Polyenes - therapeutic use polymers rats Rats, Inbred Lew synovial fluid Synovial Fluid - drug effects Synovial Fluid - metabolism viscoelasticity Viscosupplements - administration & dosage Viscosupplements - pharmacology Viscosupplements - therapeutic use |
| title | A synthetic polymeric biolubricant imparts chondroprotection in a rat meniscal tear model |
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