Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats
Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered w...
Gespeichert in:
| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-9 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9 |
|---|---|
| container_issue | 2018 |
| container_start_page | 1 |
| container_title | BioMed research international |
| container_volume | 2018 |
| creator | Kuiate, Jules-Roger Arrey Tarkang, Protus Nolé, Tsabang Tchokouaha Yamthe, Lauve Rachel Tchamgoue, Armelle D. Agbor, Gabriel Agbor |
| description | Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intubation for eight weeks (60 days), after which the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and lipid peroxidation marker (MDA) were evaluated in the heart, liver, and kidney homogenates. Plasma biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, creatinine, and urea were determined. Meanwhile, parts of the heart, kidneys, and liver were histopathologically examined. Streptozotocin administration induced toxicity in the cardiac, hepatic, and renal tissues by stimulating significant increases (p |
| doi_str_mv | 10.1155/2018/4907648 |
| format | Article |
| fullrecord | <record><control><sourceid>gale_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6286743</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A621800577</galeid><sourcerecordid>A621800577</sourcerecordid><originalsourceid>FETCH-LOGICAL-c461t-e426aa54cb921d6e4a56dbd64bcbb498ea096f01609cf2d91ef58a2c11054ebd3</originalsourceid><addsrcrecordid>eNqNkd1rFDEUxQdRbKl981kGfBHasfnemRdhWawtFJSq-BjuJHfalNlkTTJq_evNsOtafTIv98D95SSHU1XPKXlNqZRnjND2THRkoUT7qDpknIpGUUEf7zXnB9VxSneknJYq0qmn1QEnsiuSH1bjKqQ8pRoGjPWHGDKanOoVROtCc1pf4AbyLMDb-hp9aJY-u_DDWfC5_phhvut8URE3OfwMORjnm0ufC2Mgo62_uJQh1teQ07PqyQBjwuPdPKo-n7_9tLport6_u1wtrxojFM0NCqYApDB9x6hVKEAq21sletP3omsRSoqBzGHMwGxHcZAtMEMpkQJ7y4-qN1vfzdSv0Rr0OcKoN9GtId7rAE7_vfHuVt-Eb1qxVi0ELwavdgYxfJ0wZb12yeA4gscwJc2ooh0TUoiCvvwHvQtT9CVeoSSXsiXdA-oGRtTOD6G8a2ZTvVSMtoTIxaJQp1vKxJBSxGH_ZUr03Lee-9a7vgv-4mHMPfy73QKcbIFb5y18d_9ph4XBAf7QlKmu5fwXohq8KQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2153558094</pqid></control><display><type>article</type><title>Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Wiley-Blackwell Open Access Titles</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Kuiate, Jules-Roger ; Arrey Tarkang, Protus ; Nolé, Tsabang ; Tchokouaha Yamthe, Lauve Rachel ; Tchamgoue, Armelle D. ; Agbor, Gabriel Agbor</creator><contributor>Aliev, Gjumrakch ; Gjumrakch Aliev</contributor><creatorcontrib>Kuiate, Jules-Roger ; Arrey Tarkang, Protus ; Nolé, Tsabang ; Tchokouaha Yamthe, Lauve Rachel ; Tchamgoue, Armelle D. ; Agbor, Gabriel Agbor ; Aliev, Gjumrakch ; Gjumrakch Aliev</creatorcontrib><description>Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intubation for eight weeks (60 days), after which the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and lipid peroxidation marker (MDA) were evaluated in the heart, liver, and kidney homogenates. Plasma biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, creatinine, and urea were determined. Meanwhile, parts of the heart, kidneys, and liver were histopathologically examined. Streptozotocin administration induced toxicity in the cardiac, hepatic, and renal tissues by stimulating significant increases (p<0.05) in the levels of CAT and SOD, GSH, and MDA. Similarly, significant increases (P<0.05) in the levels of ALT, AST, urea, and total protein were observed in streptozotocin treated rats, whereas decreases were observed in the levels of ALP, LDH, and creatinine. Following the treatments with C. afer hydroethanolic extract prevented the effect of streptozotocin by maintaining the tissue antioxidant status (CAT, SOD, GSH, and MDA) and the plasma biochemical parameters (AST, ALT, ALP, LDH, creatinine, and urea) towards the normal ranges. The histopathological examination revealed hepatovascular congestion and leucocyte infiltration as well as renovascular congestion, glomerulosclerosis, and tubular clarification in the untreated diabetic control and their absence in the group of animals treated with a high dose of C. afer extract. The findings of the present investigation suggest that C. afer possesses antioxidant activities capable of regulating drug induced tissue damage.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/4907648</identifier><identifier>PMID: 30596093</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Alanine ; Alanine transaminase ; Alanine Transaminase - metabolism ; Albinism ; Alkaline phosphatase ; Animals ; Antioxidants ; Antioxidants - metabolism ; Aspartate ; Aspartate aminotransferase ; Aspartate Aminotransferases - metabolism ; Biomedical research ; Catalase ; Catalase - metabolism ; Congestion ; Costus - chemistry ; Costus afer ; Creatinine ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Experimental - chemically induced ; Diabetes Mellitus, Experimental - metabolism ; Enzymes ; Gene expression ; Glutathione ; Glutathione - metabolism ; Heart ; Heart - drug effects ; Herbal medicine ; Infiltration ; Insulin resistance ; Intubation ; Kidney - drug effects ; Kidney - metabolism ; Kidneys ; L-Lactate dehydrogenase ; Lactate dehydrogenase ; Lactic acid ; Lipid peroxidation ; Lipid Peroxidation - drug effects ; Lipids ; Liver ; Liver - drug effects ; Liver - metabolism ; Male ; Medicinal plants ; Medicine, Botanic ; Medicine, Herbal ; Metabolism ; Modulators ; Oxidative stress ; Oxidative Stress - drug effects ; Parameters ; Peroxidation ; Phosphatases ; Plant Extracts - pharmacology ; Plant tissues ; Protective Agents - pharmacology ; Proteins ; Rats ; Rats, Wistar ; Rodents ; Seeds ; Streptozocin ; Streptozocin - pharmacology ; Superoxide ; Superoxide dismutase ; Superoxide Dismutase - metabolism ; Toxicity ; Urea ; Ureas</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-9</ispartof><rights>Copyright © 2018 Armelle D. Tchamgoue et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Armelle D. Tchamgoue et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Armelle D. Tchamgoue et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c461t-e426aa54cb921d6e4a56dbd64bcbb498ea096f01609cf2d91ef58a2c11054ebd3</citedby><cites>FETCH-LOGICAL-c461t-e426aa54cb921d6e4a56dbd64bcbb498ea096f01609cf2d91ef58a2c11054ebd3</cites><orcidid>0000-0001-5860-9853 ; 0000-0002-2537-8953 ; 0000-0002-5134-9427 ; 0000-0002-3431-2059</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286743/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6286743/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30596093$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Aliev, Gjumrakch</contributor><contributor>Gjumrakch Aliev</contributor><creatorcontrib>Kuiate, Jules-Roger</creatorcontrib><creatorcontrib>Arrey Tarkang, Protus</creatorcontrib><creatorcontrib>Nolé, Tsabang</creatorcontrib><creatorcontrib>Tchokouaha Yamthe, Lauve Rachel</creatorcontrib><creatorcontrib>Tchamgoue, Armelle D.</creatorcontrib><creatorcontrib>Agbor, Gabriel Agbor</creatorcontrib><title>Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intubation for eight weeks (60 days), after which the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and lipid peroxidation marker (MDA) were evaluated in the heart, liver, and kidney homogenates. Plasma biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, creatinine, and urea were determined. Meanwhile, parts of the heart, kidneys, and liver were histopathologically examined. Streptozotocin administration induced toxicity in the cardiac, hepatic, and renal tissues by stimulating significant increases (p<0.05) in the levels of CAT and SOD, GSH, and MDA. Similarly, significant increases (P<0.05) in the levels of ALT, AST, urea, and total protein were observed in streptozotocin treated rats, whereas decreases were observed in the levels of ALP, LDH, and creatinine. Following the treatments with C. afer hydroethanolic extract prevented the effect of streptozotocin by maintaining the tissue antioxidant status (CAT, SOD, GSH, and MDA) and the plasma biochemical parameters (AST, ALT, ALP, LDH, creatinine, and urea) towards the normal ranges. The histopathological examination revealed hepatovascular congestion and leucocyte infiltration as well as renovascular congestion, glomerulosclerosis, and tubular clarification in the untreated diabetic control and their absence in the group of animals treated with a high dose of C. afer extract. The findings of the present investigation suggest that C. afer possesses antioxidant activities capable of regulating drug induced tissue damage.</description><subject>Alanine</subject><subject>Alanine transaminase</subject><subject>Alanine Transaminase - metabolism</subject><subject>Albinism</subject><subject>Alkaline phosphatase</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Aspartate</subject><subject>Aspartate aminotransferase</subject><subject>Aspartate Aminotransferases - metabolism</subject><subject>Biomedical research</subject><subject>Catalase</subject><subject>Catalase - metabolism</subject><subject>Congestion</subject><subject>Costus - chemistry</subject><subject>Costus afer</subject><subject>Creatinine</subject><subject>Diabetes</subject><subject>Diabetes mellitus</subject><subject>Diabetes Mellitus, Experimental - chemically induced</subject><subject>Diabetes Mellitus, Experimental - metabolism</subject><subject>Enzymes</subject><subject>Gene expression</subject><subject>Glutathione</subject><subject>Glutathione - metabolism</subject><subject>Heart</subject><subject>Heart - drug effects</subject><subject>Herbal medicine</subject><subject>Infiltration</subject><subject>Insulin resistance</subject><subject>Intubation</subject><subject>Kidney - drug effects</subject><subject>Kidney - metabolism</subject><subject>Kidneys</subject><subject>L-Lactate dehydrogenase</subject><subject>Lactate dehydrogenase</subject><subject>Lactic acid</subject><subject>Lipid peroxidation</subject><subject>Lipid Peroxidation - drug effects</subject><subject>Lipids</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Medicinal plants</subject><subject>Medicine, Botanic</subject><subject>Medicine, Herbal</subject><subject>Metabolism</subject><subject>Modulators</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - drug effects</subject><subject>Parameters</subject><subject>Peroxidation</subject><subject>Phosphatases</subject><subject>Plant Extracts - pharmacology</subject><subject>Plant tissues</subject><subject>Protective Agents - pharmacology</subject><subject>Proteins</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Rodents</subject><subject>Seeds</subject><subject>Streptozocin</subject><subject>Streptozocin - pharmacology</subject><subject>Superoxide</subject><subject>Superoxide dismutase</subject><subject>Superoxide Dismutase - metabolism</subject><subject>Toxicity</subject><subject>Urea</subject><subject>Ureas</subject><issn>2314-6133</issn><issn>2314-6141</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>RHX</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkd1rFDEUxQdRbKl981kGfBHasfnemRdhWawtFJSq-BjuJHfalNlkTTJq_evNsOtafTIv98D95SSHU1XPKXlNqZRnjND2THRkoUT7qDpknIpGUUEf7zXnB9VxSneknJYq0qmn1QEnsiuSH1bjKqQ8pRoGjPWHGDKanOoVROtCc1pf4AbyLMDb-hp9aJY-u_DDWfC5_phhvut8URE3OfwMORjnm0ufC2Mgo62_uJQh1teQ07PqyQBjwuPdPKo-n7_9tLport6_u1wtrxojFM0NCqYApDB9x6hVKEAq21sletP3omsRSoqBzGHMwGxHcZAtMEMpkQJ7y4-qN1vfzdSv0Rr0OcKoN9GtId7rAE7_vfHuVt-Eb1qxVi0ELwavdgYxfJ0wZb12yeA4gscwJc2ooh0TUoiCvvwHvQtT9CVeoSSXsiXdA-oGRtTOD6G8a2ZTvVSMtoTIxaJQp1vKxJBSxGH_ZUr03Lee-9a7vgv-4mHMPfy73QKcbIFb5y18d_9ph4XBAf7QlKmu5fwXohq8KQ</recordid><startdate>20180101</startdate><enddate>20180101</enddate><creator>Kuiate, Jules-Roger</creator><creator>Arrey Tarkang, Protus</creator><creator>Nolé, Tsabang</creator><creator>Tchokouaha Yamthe, Lauve Rachel</creator><creator>Tchamgoue, Armelle D.</creator><creator>Agbor, Gabriel Agbor</creator><general>Hindawi Publishing Corporation</general><general>Hindawi</general><general>John Wiley & Sons, Inc</general><general>Hindawi Limited</general><scope>ADJCN</scope><scope>AHFXO</scope><scope>RHU</scope><scope>RHW</scope><scope>RHX</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QO</scope><scope>7T7</scope><scope>7TK</scope><scope>7U7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>CWDGH</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5860-9853</orcidid><orcidid>https://orcid.org/0000-0002-2537-8953</orcidid><orcidid>https://orcid.org/0000-0002-5134-9427</orcidid><orcidid>https://orcid.org/0000-0002-3431-2059</orcidid></search><sort><creationdate>20180101</creationdate><title>Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats</title><author>Kuiate, Jules-Roger ; Arrey Tarkang, Protus ; Nolé, Tsabang ; Tchokouaha Yamthe, Lauve Rachel ; Tchamgoue, Armelle D. ; Agbor, Gabriel Agbor</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c461t-e426aa54cb921d6e4a56dbd64bcbb498ea096f01609cf2d91ef58a2c11054ebd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Alanine</topic><topic>Alanine transaminase</topic><topic>Alanine Transaminase - metabolism</topic><topic>Albinism</topic><topic>Alkaline phosphatase</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Aspartate</topic><topic>Aspartate aminotransferase</topic><topic>Aspartate Aminotransferases - metabolism</topic><topic>Biomedical research</topic><topic>Catalase</topic><topic>Catalase - metabolism</topic><topic>Congestion</topic><topic>Costus - chemistry</topic><topic>Costus afer</topic><topic>Creatinine</topic><topic>Diabetes</topic><topic>Diabetes mellitus</topic><topic>Diabetes Mellitus, Experimental - chemically induced</topic><topic>Diabetes Mellitus, Experimental - metabolism</topic><topic>Enzymes</topic><topic>Gene expression</topic><topic>Glutathione</topic><topic>Glutathione - metabolism</topic><topic>Heart</topic><topic>Heart - drug effects</topic><topic>Herbal medicine</topic><topic>Infiltration</topic><topic>Insulin resistance</topic><topic>Intubation</topic><topic>Kidney - drug effects</topic><topic>Kidney - metabolism</topic><topic>Kidneys</topic><topic>L-Lactate dehydrogenase</topic><topic>Lactate dehydrogenase</topic><topic>Lactic acid</topic><topic>Lipid peroxidation</topic><topic>Lipid Peroxidation - drug effects</topic><topic>Lipids</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Medicinal plants</topic><topic>Medicine, Botanic</topic><topic>Medicine, Herbal</topic><topic>Metabolism</topic><topic>Modulators</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - drug effects</topic><topic>Parameters</topic><topic>Peroxidation</topic><topic>Phosphatases</topic><topic>Plant Extracts - pharmacology</topic><topic>Plant tissues</topic><topic>Protective Agents - pharmacology</topic><topic>Proteins</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Rodents</topic><topic>Seeds</topic><topic>Streptozocin</topic><topic>Streptozocin - pharmacology</topic><topic>Superoxide</topic><topic>Superoxide dismutase</topic><topic>Superoxide Dismutase - metabolism</topic><topic>Toxicity</topic><topic>Urea</topic><topic>Ureas</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kuiate, Jules-Roger</creatorcontrib><creatorcontrib>Arrey Tarkang, Protus</creatorcontrib><creatorcontrib>Nolé, Tsabang</creatorcontrib><creatorcontrib>Tchokouaha Yamthe, Lauve Rachel</creatorcontrib><creatorcontrib>Tchamgoue, Armelle D.</creatorcontrib><creatorcontrib>Agbor, Gabriel Agbor</creatorcontrib><collection>الدوريات العلمية والإحصائية - e-Marefa Academic and Statistical Periodicals</collection><collection>معرفة - المحتوى العربي الأكاديمي المتكامل - e-Marefa Academic Complete</collection><collection>Hindawi Publishing Complete</collection><collection>Hindawi Publishing Subscription Journals</collection><collection>Hindawi Publishing Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Biotechnology Research Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Middle East & Africa Database</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BioMed research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kuiate, Jules-Roger</au><au>Arrey Tarkang, Protus</au><au>Nolé, Tsabang</au><au>Tchokouaha Yamthe, Lauve Rachel</au><au>Tchamgoue, Armelle D.</au><au>Agbor, Gabriel Agbor</au><au>Aliev, Gjumrakch</au><au>Gjumrakch Aliev</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats</atitle><jtitle>BioMed research international</jtitle><addtitle>Biomed Res Int</addtitle><date>2018-01-01</date><risdate>2018</risdate><volume>2018</volume><issue>2018</issue><spage>1</spage><epage>9</epage><pages>1-9</pages><issn>2314-6133</issn><eissn>2314-6141</eissn><abstract>Medicinal plants are efficient modulators of oxidative stress associated with diabetes mellitus. This study evaluated the cardio-, reno-, and hepato-antioxidant status of hydroethanolic extract of Costus afer on streptozotocin-intoxicated diabetic rats. Experimental animals were daily administered with hydroethanolic extract of C. afer by oral intubation for eight weeks (60 days), after which the levels of catalase (CAT), superoxide dismutase (SOD), glutathione (GSH), and lipid peroxidation marker (MDA) were evaluated in the heart, liver, and kidney homogenates. Plasma biochemical parameters such as aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), total protein, creatinine, and urea were determined. Meanwhile, parts of the heart, kidneys, and liver were histopathologically examined. Streptozotocin administration induced toxicity in the cardiac, hepatic, and renal tissues by stimulating significant increases (p<0.05) in the levels of CAT and SOD, GSH, and MDA. Similarly, significant increases (P<0.05) in the levels of ALT, AST, urea, and total protein were observed in streptozotocin treated rats, whereas decreases were observed in the levels of ALP, LDH, and creatinine. Following the treatments with C. afer hydroethanolic extract prevented the effect of streptozotocin by maintaining the tissue antioxidant status (CAT, SOD, GSH, and MDA) and the plasma biochemical parameters (AST, ALT, ALP, LDH, creatinine, and urea) towards the normal ranges. The histopathological examination revealed hepatovascular congestion and leucocyte infiltration as well as renovascular congestion, glomerulosclerosis, and tubular clarification in the untreated diabetic control and their absence in the group of animals treated with a high dose of C. afer extract. The findings of the present investigation suggest that C. afer possesses antioxidant activities capable of regulating drug induced tissue damage.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>30596093</pmid><doi>10.1155/2018/4907648</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-5860-9853</orcidid><orcidid>https://orcid.org/0000-0002-2537-8953</orcidid><orcidid>https://orcid.org/0000-0002-5134-9427</orcidid><orcidid>https://orcid.org/0000-0002-3431-2059</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2314-6133 |
| ispartof | BioMed research international, 2018-01, Vol.2018 (2018), p.1-9 |
| issn | 2314-6133 2314-6141 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6286743 |
| source | MEDLINE; PubMed Central Open Access; Wiley-Blackwell Open Access Titles; PubMed Central; Alma/SFX Local Collection |
| subjects | Alanine Alanine transaminase Alanine Transaminase - metabolism Albinism Alkaline phosphatase Animals Antioxidants Antioxidants - metabolism Aspartate Aspartate aminotransferase Aspartate Aminotransferases - metabolism Biomedical research Catalase Catalase - metabolism Congestion Costus - chemistry Costus afer Creatinine Diabetes Diabetes mellitus Diabetes Mellitus, Experimental - chemically induced Diabetes Mellitus, Experimental - metabolism Enzymes Gene expression Glutathione Glutathione - metabolism Heart Heart - drug effects Herbal medicine Infiltration Insulin resistance Intubation Kidney - drug effects Kidney - metabolism Kidneys L-Lactate dehydrogenase Lactate dehydrogenase Lactic acid Lipid peroxidation Lipid Peroxidation - drug effects Lipids Liver Liver - drug effects Liver - metabolism Male Medicinal plants Medicine, Botanic Medicine, Herbal Metabolism Modulators Oxidative stress Oxidative Stress - drug effects Parameters Peroxidation Phosphatases Plant Extracts - pharmacology Plant tissues Protective Agents - pharmacology Proteins Rats Rats, Wistar Rodents Seeds Streptozocin Streptozocin - pharmacology Superoxide Superoxide dismutase Superoxide Dismutase - metabolism Toxicity Urea Ureas |
| title | Costus afer Protects Cardio-, Hepato-, and Reno-Antioxidant Status in Streptozotocin-Intoxicated Wistar Rats |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T05%3A57%3A34IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Costus%20afer%20Protects%20Cardio-,%20Hepato-,%20and%20Reno-Antioxidant%20Status%20in%20Streptozotocin-Intoxicated%20Wistar%20Rats&rft.jtitle=BioMed%20research%20international&rft.au=Kuiate,%20Jules-Roger&rft.date=2018-01-01&rft.volume=2018&rft.issue=2018&rft.spage=1&rft.epage=9&rft.pages=1-9&rft.issn=2314-6133&rft.eissn=2314-6141&rft_id=info:doi/10.1155/2018/4907648&rft_dat=%3Cgale_pubme%3EA621800577%3C/gale_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2153558094&rft_id=info:pmid/30596093&rft_galeid=A621800577&rfr_iscdi=true |