Myeloid Disease Mutations of Splicing Factor SRSF2 Cause G2‐M Arrest and Skewed Differentiation of Human Hematopoietic Stem and Progenitor Cells

Myeloid malignancies, including myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemia, are characterized by abnormal proliferation and differentiation of hematopoietic stem and progenitor cells (HSPCs). Reports on analysis of bone marrow samples from patients have re...

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Veröffentlicht in:	Stem cells (Dayton, Ohio) Ohio), 2018-11, Vol.36 (11), p.1663-1675
Hauptverfasser:	Bapat, Aditi, Keita, Nakia, Martelly, William, Kang, Paul, Seet, Christopher, Jacobsen, Jeffery R., Stoilov, Peter, Hu, Chengcheng, Crooks, Gay M., Sharma, Shalini
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute myelogenous leukemia Acute myeloid leukemia Apoptosis Blood cancer Bone marrow Cancer Stem Cells CD34 CD34 antigen Cell Line, Tumor Cell proliferation Cells (biology) Chronic myelomonocytic leukemia Differentiation G2 Phase Cell Cycle Checkpoints - genetics Genetic transformation Hematologic malignancies Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Kinases Leukemia Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - pathology Megakaryocytes Monocytes Mutation Myelodysplastic syndrome Myeloid cells Myeloid leukemia Myelomonocytic leukemia Phenotypes Progenitor cells Proliferation Proteins RNA Splicing Factors - metabolism Splicing Splicing factors Stem cells Stem Cells - metabolism Transplantation Conditioning - methods Umbilical cord blood
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