Fingolimod enhances the efficacy of delayed alteplase administration in acute ischemic stroke by promoting anterograde reperfusion and retrograde collateral flow

Objective The present study was undertaken to determine the efficacy of coadministration of fingolimod with alteplase in acute ischemic stroke patients in a delayed time window. Methods This was a prospective, randomized, open‐label, blinded endpoint clinical trial, enrolling patients with internal...

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Veröffentlicht in:	Annals of neurology 2018-11, Vol.84 (5), p.717-728
Hauptverfasser:	Tian, De‐Cai, Shi, Kaibin, Zhu, Zilong, Yao, Jia, Yang, Xiaoxia, Su, Lei, Zhang, Sheng, Zhang, Meixia, Gonzales, Rayna J., Liu, Qiang, Huang, DeRen, Waters, Michael F., Sheth, Kevin N., Ducruet, Andrew F., Fu, Ying, Lou, Min, Shi, Fu‐Dong
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiography Carotid artery Cerebral blood flow Clinical trials Computed tomography Effectiveness Ischemia Occlusion Patients Perfusion Reperfusion Stroke Territory Thrombolytic drugs Windows (intervals)
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