Mechanistic Basis for Decreased Antimicrobial Susceptibility in a Clinical Isolate of Neisseria gonorrhoeae Possessing a Mosaic-Like mtr Efflux Pump Locus

Recent reports suggest that mosaic-like sequences within the ( ultiple ransferable esistance) efflux pump locus of , likely originating from commensal sp. by transformation, can increase the ability of gonococci to resist structurally diverse antimicrobials. Thus, acquisition of numerous nucleotide...

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Veröffentlicht in:	mBio 2018-11, Vol.9 (6)
Hauptverfasser:	Rouquette-Loughlin, Corinne E, Reimche, Jennifer L, Balthazar, Jacqueline T, Dhulipala, Vijaya, Gernert, Kim M, Kersh, Ellen N, Pham, Cau D, Pettus, Kevin, Abrams, A Jeanine, Trees, David L, St Cyr, Sancta, Shafer, William M
Format:	Artikel
Sprache:	eng
Schlagworte:	Anti-Infective Agents - metabolism Azithromycin - metabolism Biological Transport, Active Drug Resistance, Bacterial Gene Expression Regulation, Bacterial Membrane Transport Proteins - biosynthesis Molecular Biology and Physiology Mutation Neisseria gonorrhoeae - drug effects Neisseria gonorrhoeae - genetics Neisseria gonorrhoeae - metabolism Operon Promoter Regions, Genetic Repressor Proteins - genetics Transcription, Genetic
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