Lecithin-Stabilized Polymeric Micelles (LsbPMs) for Delivering Quercetin: Pharmacokinetic Studies and Therapeutic Effects of Quercetin Alone and in Combination with Doxorubicin

In this study, lecithin-stabilized polymeric micelles (L sb PMs) were prepared to load quercetin (QUE) in order to improve its bioavailability and increase its antitumor activity. Its combination with doxorubicin (DOX) to minimize DOX-mediated cardiac toxicity and increase the antitumor activity of...

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Veröffentlicht in:	Scientific reports 2018-12, Vol.8 (1), p.17640-11, Article 17640
Hauptverfasser:	Chang, Chia-En, Hsieh, Chien-Ming, Huang, Sheng-Chin, Su, Chia-Yu, Sheu, Ming-Thau, Ho, Hsiu-O.
Format:	Artikel
Sprache:	eng
Schlagworte:	639/638/455/957 639/925/352/152 64 64/60 Antitumor activity Bioavailability Breast cancer Colon cancer Colorectal cancer Controlled release Cytotoxicity Doxorubicin Heart Humanities and Social Sciences Intravenous administration Lecithin Micelles multidisciplinary Oral administration Pharmacokinetics Polyethylene glycol Quercetin Science Science (multidisciplinary)
Online-Zugang:	Volltext
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