MMB triazole analogs are potent NF-κB inhibitors and anti-cancer agents against both hematological and solid tumor cells

Triazole derivatives of melampomagnolide B (MMB) have been synthesized via click chemistry methodologies and screened against a panel of 60 human cancer cell lines. Several derivatives showed promising anti-cancer activity, affording growth inhibition (GI50) values in the nanomolar range (GI50 = 0.0...

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Veröffentlicht in:	European journal of medicinal chemistry 2018-09, Vol.157, p.562-581
Hauptverfasser:	Janganati, Venumadhav, Ponder, Jessica, Balasubramaniam, Meenakshisundaram, Bhat-Nakshatri, Poornima, Bar, Eli E., Nakshatri, Harikrishna, Jordan, Craig T., Crooks, Peter A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology Cell Line, Tumor Cell Proliferation - drug effects Click chemistry Dose-Response Relationship, Drug Humans Leukemia cell lines Melampomagnolide B Models, Molecular Molecular Structure NF-kappa B - antagonists & inhibitors NF-kappa B - metabolism NF-κB pathway Phosphorylation - drug effects Sesquiterpenes - chemistry Sesquiterpenes - pharmacology Structure-Activity Relationship Triazole derivatives Triazoles - chemistry Triazoles - pharmacology
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