Foxp3 expression in induced regulatory T cells is stabilized by C/EBP in inflammatory environments

Proper control of immune responses by Foxp3 + regulatory T cells at inflamed sites is crucial for the prevention of immunopathology. TGF‐β‐induced Foxp3 + regulatory T (T reg ) cells are generated in inflammatory environments as well as in steady‐state conditions. Inflammatory cytokines such as IFN‐...

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Veröffentlicht in:	EMBO reports 2018-12, Vol.19 (12), p.n/a
Hauptverfasser:	Lee, Sungkyu, Park, Kyungsoo, Kim, Jieun, Min, Hyungyu, Seong, Rho H
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Animal models Animals Base Sequence C/EBP CCAAT-Enhancer-Binding Proteins - metabolism CCAAT/enhancer-binding protein CD4 antigen Colitis - immunology Colitis - pathology Cytokines Cytokines - pharmacology DNA Methylation - genetics EMBO09 EMBO19 EMBO44 Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Forkhead Transcription Factors - metabolism Foxp3 Foxp3 protein Gene expression Humans Immunoregulation Inflammation Inflammation - metabolism Inflammation - pathology inflammatory cytokines Interferon iTreg Lymphocytes Lymphocytes T Mice, Transgenic Protein Binding Proteins Response Elements - genetics Retinoic acid T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - metabolism Tretinoin - pharmacology Up-Regulation - drug effects
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