Recommendation to use exact P-values in biomarker discovery research in place of approximate P-values

•Normal and logit-normal approximate P-values are frequently used in biomarker studies.•Approximate P-values can lead to inappropriate biomarker selection rules.•Use of exact P-values may improve the yield of biomarkers that validate clinically. Biomarker candidates are often ranked using P-values....

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Veröffentlicht in:	Cancer epidemiology 2018-10, Vol.56, p.83-89
Hauptverfasser:	Buas, Matthew F., Li, Christopher I., Anderson, Garnet L., Pepe, Margaret S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Arrays Biomarkers Biomarkers - analysis Breast cancer Cancer Colorectal cancer Computational Biology - methods Computational Biology - standards Data analysis Data Interpretation, Statistical Data processing Empirical analysis Epidemiology Humans Hypothesis tests Models, Statistical Permutations Proteins ROC curve Simulation Statistical analysis Statistical tests Statistics Studies
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