Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study
ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignN...
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| creator | Wen, Simin Wu, Yanhua Pan, Yuchen Cao, Mengzhuo Zhao, Dan Wang, Chong Wang, Chuan Kong, Fei Li, Jie Niu, Junqi Jiang, Jing |
| description | ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignNested case–control study.SettingChangchun, China.Participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.ResultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.ConclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies. |
| doi_str_mv | 10.1136/bmjopen-2018-022334 |
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| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6278805</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2139017593</sourcerecordid><originalsourceid>FETCH-LOGICAL-b472t-396f5a06efc166e38ab5574f917e471a3d6b8fbb2bfe10681fa0e97e237ff8393</originalsourceid><addsrcrecordid>eNqNks-KFDEQxhtR3GXdJxAk4GUX6d2kk_QfDwszgzoLA4Ko15Dursxk6E7aru6RuXn0rK_j0-yTmKHHZfVkLvmgfvVVFXxR9JzRK8Z4el22W9-BixPK8pgmCefiUXSaUCHilEr5-IE-ic4RtzQ8IQspk6fRCaeiyCnPT6NfM0RfWT1Y74g35HYVM0q0qyf1YUbQunUDxI1VA36wNZDON_vW993GYovkqx02ZNgA6QE779DuwAEiGTxZzj-Tna4q6yZ_68hiY0MVgjTaDXgYuZzjbH3x6vJ6OYcg7r7_uCStD449viaaBHyAmlQa4e7bz8q7ofcNwWGs98-iJ0Y3COfH_yz69PbNx8UyXr1_d7uYreJSZMkQ8yI1UtMUTMXSFHiuSykzYQqWgciY5nVa5qYsk9IAo2nOjKZQZJDwzJicF_wsupl8u7Fsoa4g7KAb1fW21f1eeW3V3xVnN2rtdypNsjynMhhcHA16_2UMB6nWYgVNox34EVXCBKNcSiEC-vIfdOvH3oXzAsULyjJZ8EDxiap6j9iDuV-GUXUIiDoGRB0CoqaAhK4XD--47_kThwBcTUDo_i_H30bByo8</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2139017593</pqid></control><display><type>article</type><title>Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study</title><source>BMJ Open Access Journals</source><source>DOAJ Directory of Open Access Journals</source><source>PubMed Central Open Access</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><creator>Wen, Simin ; Wu, Yanhua ; Pan, Yuchen ; Cao, Mengzhuo ; Zhao, Dan ; Wang, Chong ; Wang, Chuan ; Kong, Fei ; Li, Jie ; Niu, Junqi ; Jiang, Jing</creator><creatorcontrib>Wen, Simin ; Wu, Yanhua ; Pan, Yuchen ; Cao, Mengzhuo ; Zhao, Dan ; Wang, Chong ; Wang, Chuan ; Kong, Fei ; Li, Jie ; Niu, Junqi ; Jiang, Jing</creatorcontrib><description>ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignNested case–control study.SettingChangchun, China.Participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.ResultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.ConclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.</description><identifier>ISSN: 2044-6055</identifier><identifier>EISSN: 2044-6055</identifier><identifier>DOI: 10.1136/bmjopen-2018-022334</identifier><identifier>PMID: 30498038</identifier><language>eng</language><publisher>England: BMJ Publishing Group LTD</publisher><subject>Age ; Antigens ; Cytokines ; Genes ; Genetics and Genomics ; Hepatitis ; Infections ; Laboratories ; Mothers ; Population ; Vaccines</subject><ispartof>BMJ open, 2018-11, Vol.8 (11), p.e022334-e022334</ispartof><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</rights><rights>2018 Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ . Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>Author(s) (or their employer(s)) 2018. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-b472t-396f5a06efc166e38ab5574f917e471a3d6b8fbb2bfe10681fa0e97e237ff8393</citedby><cites>FETCH-LOGICAL-b472t-396f5a06efc166e38ab5574f917e471a3d6b8fbb2bfe10681fa0e97e237ff8393</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://bmjopen.bmj.com/content/8/11/e022334.full.pdf$$EPDF$$P50$$Gbmj$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://bmjopen.bmj.com/content/8/11/e022334.full$$EHTML$$P50$$Gbmj$$Hfree_for_read</linktohtml><link.rule.ids>230,314,724,777,781,861,882,27530,27531,27905,27906,53772,53774,77350,77381</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30498038$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wen, Simin</creatorcontrib><creatorcontrib>Wu, Yanhua</creatorcontrib><creatorcontrib>Pan, Yuchen</creatorcontrib><creatorcontrib>Cao, Mengzhuo</creatorcontrib><creatorcontrib>Zhao, Dan</creatorcontrib><creatorcontrib>Wang, Chong</creatorcontrib><creatorcontrib>Wang, Chuan</creatorcontrib><creatorcontrib>Kong, Fei</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Niu, Junqi</creatorcontrib><creatorcontrib>Jiang, Jing</creatorcontrib><title>Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study</title><title>BMJ open</title><addtitle>BMJ Open</addtitle><description>ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignNested case–control study.SettingChangchun, China.Participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.ResultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.ConclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.</description><subject>Age</subject><subject>Antigens</subject><subject>Cytokines</subject><subject>Genes</subject><subject>Genetics and Genomics</subject><subject>Hepatitis</subject><subject>Infections</subject><subject>Laboratories</subject><subject>Mothers</subject><subject>Population</subject><subject>Vaccines</subject><issn>2044-6055</issn><issn>2044-6055</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>9YT</sourceid><sourceid>ACMMV</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNks-KFDEQxhtR3GXdJxAk4GUX6d2kk_QfDwszgzoLA4Ko15Dursxk6E7aru6RuXn0rK_j0-yTmKHHZfVkLvmgfvVVFXxR9JzRK8Z4el22W9-BixPK8pgmCefiUXSaUCHilEr5-IE-ic4RtzQ8IQspk6fRCaeiyCnPT6NfM0RfWT1Y74g35HYVM0q0qyf1YUbQunUDxI1VA36wNZDON_vW993GYovkqx02ZNgA6QE779DuwAEiGTxZzj-Tna4q6yZ_68hiY0MVgjTaDXgYuZzjbH3x6vJ6OYcg7r7_uCStD449viaaBHyAmlQa4e7bz8q7ofcNwWGs98-iJ0Y3COfH_yz69PbNx8UyXr1_d7uYreJSZMkQ8yI1UtMUTMXSFHiuSykzYQqWgciY5nVa5qYsk9IAo2nOjKZQZJDwzJicF_wsupl8u7Fsoa4g7KAb1fW21f1eeW3V3xVnN2rtdypNsjynMhhcHA16_2UMB6nWYgVNox34EVXCBKNcSiEC-vIfdOvH3oXzAsULyjJZ8EDxiap6j9iDuV-GUXUIiDoGRB0CoqaAhK4XD--47_kThwBcTUDo_i_H30bByo8</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Wen, Simin</creator><creator>Wu, Yanhua</creator><creator>Pan, Yuchen</creator><creator>Cao, Mengzhuo</creator><creator>Zhao, Dan</creator><creator>Wang, Chong</creator><creator>Wang, Chuan</creator><creator>Kong, Fei</creator><creator>Li, Jie</creator><creator>Niu, Junqi</creator><creator>Jiang, Jing</creator><general>BMJ Publishing Group LTD</general><general>BMJ Publishing Group</general><scope>9YT</scope><scope>ACMMV</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>88G</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BTHHO</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>M2M</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PSYQQ</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20181101</creationdate><title>Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study</title><author>Wen, Simin ; Wu, Yanhua ; Pan, Yuchen ; Cao, Mengzhuo ; Zhao, Dan ; Wang, Chong ; Wang, Chuan ; Kong, Fei ; Li, Jie ; Niu, Junqi ; Jiang, Jing</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-b472t-396f5a06efc166e38ab5574f917e471a3d6b8fbb2bfe10681fa0e97e237ff8393</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Age</topic><topic>Antigens</topic><topic>Cytokines</topic><topic>Genes</topic><topic>Genetics and Genomics</topic><topic>Hepatitis</topic><topic>Infections</topic><topic>Laboratories</topic><topic>Mothers</topic><topic>Population</topic><topic>Vaccines</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Simin</creatorcontrib><creatorcontrib>Wu, Yanhua</creatorcontrib><creatorcontrib>Pan, Yuchen</creatorcontrib><creatorcontrib>Cao, Mengzhuo</creatorcontrib><creatorcontrib>Zhao, Dan</creatorcontrib><creatorcontrib>Wang, Chong</creatorcontrib><creatorcontrib>Wang, Chuan</creatorcontrib><creatorcontrib>Kong, Fei</creatorcontrib><creatorcontrib>Li, Jie</creatorcontrib><creatorcontrib>Niu, Junqi</creatorcontrib><creatorcontrib>Jiang, Jing</creatorcontrib><collection>BMJ Open Access Journals</collection><collection>BMJ Journals:Open Access</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>BMJ Journals</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>BMJ open</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Simin</au><au>Wu, Yanhua</au><au>Pan, Yuchen</au><au>Cao, Mengzhuo</au><au>Zhao, Dan</au><au>Wang, Chong</au><au>Wang, Chuan</au><au>Kong, Fei</au><au>Li, Jie</au><au>Niu, Junqi</au><au>Jiang, Jing</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study</atitle><jtitle>BMJ open</jtitle><addtitle>BMJ Open</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>8</volume><issue>11</issue><spage>e022334</spage><epage>e022334</epage><pages>e022334-e022334</pages><issn>2044-6055</issn><eissn>2044-6055</eissn><abstract>ObjectivesTo investigate the association of interleukin (IL)-10 and IL-10 receptor A (IL-10RA) single nucleotide polymorphisms with the responsiveness to hepatitis B virus (HBV) vaccination in newborns whose mothers were hepatitis B surface antigen (HBsAg)(+)/hepatitis B e antigen (HBeAg)(–).DesignNested case–control study.SettingChangchun, China.Participants713 infants from a Han Chinese population whose mothers were HBsAg(+)/HBeAg(–) and participated in the prevention of mother-to-child transmission of HBV at the First Hospital of Jilin University from July 2012 to July 2015 were included. Infants were excluded for HBsAg-positive; unstandardised vaccination process; inadequate blood samples; not Han Chinese and failed genotyping.ResultsInfants with artificial feeding pattern were correlated with low responsiveness to HBV vaccination (p=0.009). The GG genotype of IL-10 rs3021094 was correlated with a higher risk of low responsiveness to HBV vaccination (OR 2.80, 95% CI 1.35 to 5.83). No haplotype was found to be correlated with responsiveness to HBV vaccination. No gene–gene interaction was found between IL-10 and IL-10RA.ConclusionsOur study found that IL-10 gene variants were significantly associated with the immune response to the HBV vaccine. Identifying these high-risk infants who born to HBsAg(+)/HBeAg(–) mothers and low responses to hepatitis B vaccination will provide evidence for individualised prevention strategies.</abstract><cop>England</cop><pub>BMJ Publishing Group LTD</pub><pmid>30498038</pmid><doi>10.1136/bmjopen-2018-022334</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Age Antigens Cytokines Genes Genetics and Genomics Hepatitis Infections Laboratories Mothers Population Vaccines |
| title | Association of IL-10 and IL-10RA single nucleotide polymorphisms with the responsiveness to HBV vaccination in Chinese infants of HBsAg(+)/HBeAg(−) mothers: a nested case–control study |
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