Inhibition of MyD88 Signaling Skews Microglia/Macrophage Polarization and Attenuates Neuronal Apoptosis in the Hippocampus After Status Epilepticus in Mice

Inflammation is implicated in epileptogenesis. Activated microglia and macrophages (MG/MΦ) are found in the brains of patients with epilepsy-related diseases and animal models of epilepsy. It is not yet known how the MG/MΦ activation phenotype affects pathological changes in the brain after a single...

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Veröffentlicht in:	Neurotherapeutics 2018-10, Vol.15 (4), p.1093-1111
Hauptverfasser:	Liu, Jin-Tao, Wu, Sheng-Xi, Zhang, Hua, Kuang, Fang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Apoptosis Apoptosis - genetics Apoptosis - physiology Arginase Astrocytes Biomedical and Life Sciences Biomedicine CD163 antigen Cell Polarity - genetics Cytokines - metabolism Disease Models, Animal Epilepsy Female Gene Expression Regulation, Archaeal - drug effects Gene Expression Regulation, Archaeal - genetics Gliosis Glutamic acid receptors Glutamic acid transporter Hippocampus Hippocampus - metabolism Hippocampus - pathology Immunohistochemistry In Situ Nick-End Labeling Lithium Lithium - toxicity Macrophages Macrophages - pathology Mannose Mice Mice, Inbred C57BL Mice, Transgenic Microglia Microglia - pathology Microglia/macrophage polarization MyD88 MyD88 protein Myeloid Differentiation Factor 88 - antagonists & inhibitors Myeloid Differentiation Factor 88 - chemistry Myeloid Differentiation Factor 88 - deficiency N-Methyl-D-aspartic acid receptors Neurobiology Neuroinflammation Neurology Neurons - pathology Neuroprotection Neurosciences Neurosurgery Original Original Article Peptides - therapeutic use Phenotypes Pilocarpine Pilocarpine - toxicity Polarization Pyramidal cells Seizures Signal Transduction - genetics Status epilepticus Status Epilepticus - chemically induced Status Epilepticus - genetics Status Epilepticus - pathology Toll-Like Receptor 4 - metabolism Western blotting
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