Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data
To evaluate patterns of lymph flow from primary lesions in patients with cervical cancer and to determine how useful for radiotherapy planning this information can be. SPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acq...
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| Veröffentlicht in: | Reports of practical oncology and radiotherapy 2018-11, Vol.23 (6), p.503-509 |
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| creator | Novikov, Sergey Nikolaevich Krzhivitskii, Pavel Ivanovich Kanaev, Sergey Vasilevich Berlev, Igor Viktorovitch Kargopolova, Margarita Viktorovna Ibragimov, Zaur Bisyarin, Mikhail Saveleva, Valentina Vladimirovna |
| description | To evaluate patterns of lymph flow from primary lesions in patients with cervical cancer and to determine how useful for radiotherapy planning this information can be.
SPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acquisition started 120–240min after 4 peritumoral injections of 99mTc-radiocolloids (150–300MBq in 0.4–1ml). We determined localization of LN with uptake of radiocolloids, type of lymph flow (mono-, bi-lateral) and lymph flow patterns (supraureteral paracervical, infraureteral paracervical and directly to para-aortic LNs).
SLNs were visualized in 31 of 36 women. Bilateral lymph-flow was detected in 22 (71%), monolateral – in the other 9 (29%) cases. The distribution of SLNs was as follows: external iliac – 64.5%, internal iliac – 54.8%, obturator – 32.2%, common iliac – 35.5% and pre-sacral 3.2%. Para-aortic LNs were visualized in 5 (16.1%) patients. The supraureteral paracervical pattern of lymph flow was identified in 22, infraureteral paracervical – in 4 and their combination – in the other 5 women.
Visualization of an individual pattern of lymph flow from primary cervical cancer can be considered as a promising tool for optimization of the volume of irradiated regional LNs. |
| doi_str_mv | 10.1016/j.rpor.2018.05.008 |
| format | Article |
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SPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acquisition started 120–240min after 4 peritumoral injections of 99mTc-radiocolloids (150–300MBq in 0.4–1ml). We determined localization of LN with uptake of radiocolloids, type of lymph flow (mono-, bi-lateral) and lymph flow patterns (supraureteral paracervical, infraureteral paracervical and directly to para-aortic LNs).
SLNs were visualized in 31 of 36 women. Bilateral lymph-flow was detected in 22 (71%), monolateral – in the other 9 (29%) cases. The distribution of SLNs was as follows: external iliac – 64.5%, internal iliac – 54.8%, obturator – 32.2%, common iliac – 35.5% and pre-sacral 3.2%. Para-aortic LNs were visualized in 5 (16.1%) patients. The supraureteral paracervical pattern of lymph flow was identified in 22, infraureteral paracervical – in 4 and their combination – in the other 5 women.
Visualization of an individual pattern of lymph flow from primary cervical cancer can be considered as a promising tool for optimization of the volume of irradiated regional LNs.</description><identifier>ISSN: 1507-1367</identifier><identifier>EISSN: 2083-4640</identifier><identifier>DOI: 10.1016/j.rpor.2018.05.008</identifier><identifier>PMID: 30534013</identifier><language>eng</language><publisher>Poland: Elsevier Sp. z o.o</publisher><subject>Cervical cancer ; Lymph flow ; Radiotherapy ; Sentinel lymph nodes ; Special issue paper ; SPECT–CT</subject><ispartof>Reports of practical oncology and radiotherapy, 2018-11, Vol.23 (6), p.503-509</ispartof><rights>2018 Greater Poland Cancer Centre</rights><rights>2018 Greater Poland Cancer Centre. Published by Elsevier Sp. z o.o. All rights reserved. 2018 Greater Poland Cancer Centre</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c455t-d58178c2f68829d49685584725e5f283cbd13027a611afd1a9d033328348a3ad3</citedby><cites>FETCH-LOGICAL-c455t-d58178c2f68829d49685584725e5f283cbd13027a611afd1a9d033328348a3ad3</cites><orcidid>0000-0002-7185-1967</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6277276/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.rpor.2018.05.008$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>230,315,728,781,785,865,886,3551,27926,27927,45997,53793,53795</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30534013$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Novikov, Sergey Nikolaevich</creatorcontrib><creatorcontrib>Krzhivitskii, Pavel Ivanovich</creatorcontrib><creatorcontrib>Kanaev, Sergey Vasilevich</creatorcontrib><creatorcontrib>Berlev, Igor Viktorovitch</creatorcontrib><creatorcontrib>Kargopolova, Margarita Viktorovna</creatorcontrib><creatorcontrib>Ibragimov, Zaur</creatorcontrib><creatorcontrib>Bisyarin, Mikhail</creatorcontrib><creatorcontrib>Saveleva, Valentina Vladimirovna</creatorcontrib><title>Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data</title><title>Reports of practical oncology and radiotherapy</title><addtitle>Rep Pract Oncol Radiother</addtitle><description>To evaluate patterns of lymph flow from primary lesions in patients with cervical cancer and to determine how useful for radiotherapy planning this information can be.
SPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acquisition started 120–240min after 4 peritumoral injections of 99mTc-radiocolloids (150–300MBq in 0.4–1ml). We determined localization of LN with uptake of radiocolloids, type of lymph flow (mono-, bi-lateral) and lymph flow patterns (supraureteral paracervical, infraureteral paracervical and directly to para-aortic LNs).
SLNs were visualized in 31 of 36 women. Bilateral lymph-flow was detected in 22 (71%), monolateral – in the other 9 (29%) cases. The distribution of SLNs was as follows: external iliac – 64.5%, internal iliac – 54.8%, obturator – 32.2%, common iliac – 35.5% and pre-sacral 3.2%. Para-aortic LNs were visualized in 5 (16.1%) patients. The supraureteral paracervical pattern of lymph flow was identified in 22, infraureteral paracervical – in 4 and their combination – in the other 5 women.
Visualization of an individual pattern of lymph flow from primary cervical cancer can be considered as a promising tool for optimization of the volume of irradiated regional LNs.</description><subject>Cervical cancer</subject><subject>Lymph flow</subject><subject>Radiotherapy</subject><subject>Sentinel lymph nodes</subject><subject>Special issue paper</subject><subject>SPECT–CT</subject><issn>1507-1367</issn><issn>2083-4640</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNp9kU2LFDEQhoMo7rDuH_AgOXrp3nx0PkZEkEVXYUAPeg7ZJD1TQ3fSJj2zzNVfbtpZF72YSwrqqbde6kXoJSUtJVRe79s8pdwyQnVLREuIfoJWjGjedLIjT9GKCqIayqW6QFel7MnyFGFCPUcXnAjeEcpX6OfmNE473A_pHm8P4IPHkLP1YGdIEace57CtlR3w8JuMyYeCIeKpEiHOBd_DvMMu5CO4Sjkba_0Gf81hgBGizSds6_ipQFnkioM4wzbbaQcOezvbF-hZb4cSrh7-S_T944dvN5-azZfbzzfvN43rhJgbLzRV2rFeas3WvltLLYTuFBNB9Exzd-cpJ0xZSantPbVrTzjntdNpy63nl-jdWXc63I3Bu2o-28FMGcZq0iQL5t9OhJ3ZpqORTCmmZBV4_SCQ049DKLMZobgwDDaGdCiGUSGoZGveVZSdUZdTKTn0j2soMUt-Zm-W_MySnyHC1Pzq0Ku_DT6O_EmrAm_PQKhnOkLIpl4z1Ht7yMHNxif4n_4vbu2u8w</recordid><startdate>20181101</startdate><enddate>20181101</enddate><creator>Novikov, Sergey Nikolaevich</creator><creator>Krzhivitskii, Pavel Ivanovich</creator><creator>Kanaev, Sergey Vasilevich</creator><creator>Berlev, Igor Viktorovitch</creator><creator>Kargopolova, Margarita Viktorovna</creator><creator>Ibragimov, Zaur</creator><creator>Bisyarin, Mikhail</creator><creator>Saveleva, Valentina Vladimirovna</creator><general>Elsevier Sp. z o.o</general><general>Elsevier</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7185-1967</orcidid></search><sort><creationdate>20181101</creationdate><title>Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data</title><author>Novikov, Sergey Nikolaevich ; Krzhivitskii, Pavel Ivanovich ; Kanaev, Sergey Vasilevich ; Berlev, Igor Viktorovitch ; Kargopolova, Margarita Viktorovna ; Ibragimov, Zaur ; Bisyarin, Mikhail ; Saveleva, Valentina Vladimirovna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c455t-d58178c2f68829d49685584725e5f283cbd13027a611afd1a9d033328348a3ad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Cervical cancer</topic><topic>Lymph flow</topic><topic>Radiotherapy</topic><topic>Sentinel lymph nodes</topic><topic>Special issue paper</topic><topic>SPECT–CT</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Novikov, Sergey Nikolaevich</creatorcontrib><creatorcontrib>Krzhivitskii, Pavel Ivanovich</creatorcontrib><creatorcontrib>Kanaev, Sergey Vasilevich</creatorcontrib><creatorcontrib>Berlev, Igor Viktorovitch</creatorcontrib><creatorcontrib>Kargopolova, Margarita Viktorovna</creatorcontrib><creatorcontrib>Ibragimov, Zaur</creatorcontrib><creatorcontrib>Bisyarin, Mikhail</creatorcontrib><creatorcontrib>Saveleva, Valentina Vladimirovna</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Reports of practical oncology and radiotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Novikov, Sergey Nikolaevich</au><au>Krzhivitskii, Pavel Ivanovich</au><au>Kanaev, Sergey Vasilevich</au><au>Berlev, Igor Viktorovitch</au><au>Kargopolova, Margarita Viktorovna</au><au>Ibragimov, Zaur</au><au>Bisyarin, Mikhail</au><au>Saveleva, Valentina Vladimirovna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data</atitle><jtitle>Reports of practical oncology and radiotherapy</jtitle><addtitle>Rep Pract Oncol Radiother</addtitle><date>2018-11-01</date><risdate>2018</risdate><volume>23</volume><issue>6</issue><spage>503</spage><epage>509</epage><pages>503-509</pages><issn>1507-1367</issn><eissn>2083-4640</eissn><abstract>To evaluate patterns of lymph flow from primary lesions in patients with cervical cancer and to determine how useful for radiotherapy planning this information can be.
SPECT–CT visualization of sentinel (SLN) lymph nodes (LNs) was performed in 36 primary patients with IB-IIB cervical cancer. The acquisition started 120–240min after 4 peritumoral injections of 99mTc-radiocolloids (150–300MBq in 0.4–1ml). We determined localization of LN with uptake of radiocolloids, type of lymph flow (mono-, bi-lateral) and lymph flow patterns (supraureteral paracervical, infraureteral paracervical and directly to para-aortic LNs).
SLNs were visualized in 31 of 36 women. Bilateral lymph-flow was detected in 22 (71%), monolateral – in the other 9 (29%) cases. The distribution of SLNs was as follows: external iliac – 64.5%, internal iliac – 54.8%, obturator – 32.2%, common iliac – 35.5% and pre-sacral 3.2%. Para-aortic LNs were visualized in 5 (16.1%) patients. The supraureteral paracervical pattern of lymph flow was identified in 22, infraureteral paracervical – in 4 and their combination – in the other 5 women.
Visualization of an individual pattern of lymph flow from primary cervical cancer can be considered as a promising tool for optimization of the volume of irradiated regional LNs.</abstract><cop>Poland</cop><pub>Elsevier Sp. z o.o</pub><pmid>30534013</pmid><doi>10.1016/j.rpor.2018.05.008</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0002-7185-1967</orcidid><oa>free_for_read</oa></addata></record> |
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| source | DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Access via ScienceDirect (Elsevier); PubMed Central |
| subjects | Cervical cancer Lymph flow Radiotherapy Sentinel lymph nodes Special issue paper SPECT–CT |
| title | Lymph flow guided irradiation of regional lymph nodes in patients with cervical cancer: Preliminary analysis of scintigraphic data |
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