Obesity and increased susceptibility to arsenic-related type 2 diabetes in Northern Chile

The prevalence of type 2 diabetes (T2D) has nearly doubled since 1980. Elevated body mass index (BMI) is the leading risk factor for T2D, mediated by inflammation and oxidative stress. Arsenic shares similar pathogenic processes, and may contribute to hyperglycemia and β-cell dysfunction. We assesse...

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Veröffentlicht in:	Environmental research 2018-11, Vol.167, p.248-254
Hauptverfasser:	Castriota, Felicia, Acevedo, Johanna, Ferreccio, Catterina, Smith, Allan H., Liaw, Jane, Smith, Martyn T., Steinmaus, Craig
Format:	Artikel
Sprache:	eng
Schlagworte:	60 APPLIED LIFE SCIENCES Aged ARSENIC Arsenic - toxicity BIOLOGICAL STRESS Body Mass Index Body Mass Index (BMI) Case-Control Studies CHILE data collection Diabetes Mellitus, Type 2 - chemically induced Diabetes Mellitus, Type 2 - epidemiology diet drug therapy Female HEALTH HAZARDS Humans HYPERGLYCEMIA INFLAMMATION islets of Langerhans LIFETIME Male METABOLIC DISEASES Middle Aged neoplasms noninsulin-dependent diabetes mellitus Obesity Obesity - epidemiology odds ratio OXIDATION oxidative stress Risk Factors Synergy Type 2 diabetes (T2D)
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