Transcriptional Profiling of Leucocyte Count Variation from Porcine Peripheral Blood Reveals Differential Gene Expression
Leucocytes have tremendous health-check importance related to the individual antiviral capacity of pigs and other mammals. However, the molecular mechanism of the immune response of blood leucocytes in pigs is not completely known. This study investigated the leucocyte-count variation before and aft...
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| Veröffentlicht in: | BioMed research international 2018-01, Vol.2018 (2018), p.1-11 |
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| creator | Wang, Haiyan Ma, Yunlong Li, Xinyun Zhu, Mengjin Du, Xiaoyong Bhuiyan, Ali Akbar Tran Thi, Thuy Nhien Liu, Xiangdong Adetula, Adeyinka Abiola Zhao, Shuhong |
| description | Leucocytes have tremendous health-check importance related to the individual antiviral capacity of pigs and other mammals. However, the molecular mechanism of the immune response of blood leucocytes in pigs is not completely known. This study investigated the leucocyte-count variation before and after poly I:C stimulation in a Duroc–Erhualian F2 population. Pigs with increased and decreased differences in leucocyte counts were coded as increased responder (IR) and decreased responder (DR), respectively. Then, we used microarray technology to compare the gene-expression profiles of both groups of pigs. Transcriptomic analysis identified 129 differentially expressed genes (DEGs) in IR pigs and 136 DEGs in DR pigs. Forty-one common DEGs showed that both groups had similar expression patterns of immune responses. These results illustrated a differential expression in both groups. Furthermore, qPCR experiment was performed to verify the differential-expression profile. Functional annotation of the DEGs indicated that both IR and DR pigs were similar in several biological processes, including innate immune response, and also exhibited distinct differences in biological processes, molecular function, and pathways. These results provided insights into the mechanism underlying the antiviral capacity of pigs. Trial registration number is CAS Registry Number 24939-03-5. |
| doi_str_mv | 10.1155/2018/1496536 |
| format | Article |
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However, the molecular mechanism of the immune response of blood leucocytes in pigs is not completely known. This study investigated the leucocyte-count variation before and after poly I:C stimulation in a Duroc–Erhualian F2 population. Pigs with increased and decreased differences in leucocyte counts were coded as increased responder (IR) and decreased responder (DR), respectively. Then, we used microarray technology to compare the gene-expression profiles of both groups of pigs. Transcriptomic analysis identified 129 differentially expressed genes (DEGs) in IR pigs and 136 DEGs in DR pigs. Forty-one common DEGs showed that both groups had similar expression patterns of immune responses. These results illustrated a differential expression in both groups. Furthermore, qPCR experiment was performed to verify the differential-expression profile. Functional annotation of the DEGs indicated that both IR and DR pigs were similar in several biological processes, including innate immune response, and also exhibited distinct differences in biological processes, molecular function, and pathways. These results provided insights into the mechanism underlying the antiviral capacity of pigs. Trial registration number is CAS Registry Number 24939-03-5.</description><identifier>ISSN: 2314-6133</identifier><identifier>EISSN: 2314-6141</identifier><identifier>DOI: 10.1155/2018/1496536</identifier><identifier>PMID: 30581844</identifier><language>eng</language><publisher>Cairo, Egypt: Hindawi Publishing Corporation</publisher><subject>Annotations ; Antiviral agents ; Biological activity ; Biomedical research ; Biotechnology industry ; Blood ; Cytokines ; Dendritic cells ; Direct reduction ; DNA microarrays ; Fever ; Gene expression ; Genes ; Genetic aspects ; Genetic research ; Genetic transcription ; Hogs ; Immune response ; Immune system ; Infections ; Influenza ; Infrared radiation ; Innate immunity ; Laboratory animals ; Leukocytes ; Peripheral blood ; Polyinosinic:polycytidylic acid ; Proteins ; Swine ; Transcription ; Viral infections ; Viruses</subject><ispartof>BioMed research international, 2018-01, Vol.2018 (2018), p.1-11</ispartof><rights>Copyright © 2018 Adeyinka Abiola Adetula et al.</rights><rights>COPYRIGHT 2018 John Wiley & Sons, Inc.</rights><rights>Copyright © 2018 Adeyinka Abiola Adetula et al. This is an open access article distributed under the Creative Commons Attribution License (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. https://creativecommons.org/licenses/by/4.0</rights><rights>Copyright © 2018 Adeyinka Abiola Adetula et al. 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c499t-56ce70537888c5182c88d0d0ec2d360d42be0c224c6a1c0b963f7b45d9fafe5a3</citedby><cites>FETCH-LOGICAL-c499t-56ce70537888c5182c88d0d0ec2d360d42be0c224c6a1c0b963f7b45d9fafe5a3</cites><orcidid>0000-0001-8617-6848 ; 0000-0002-7943-1713 ; 0000-0002-9892-3887 ; 0000-0002-1865-0007</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276489/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6276489/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30581844$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><contributor>Moreaux, Jerome</contributor><creatorcontrib>Wang, Haiyan</creatorcontrib><creatorcontrib>Ma, Yunlong</creatorcontrib><creatorcontrib>Li, Xinyun</creatorcontrib><creatorcontrib>Zhu, Mengjin</creatorcontrib><creatorcontrib>Du, Xiaoyong</creatorcontrib><creatorcontrib>Bhuiyan, Ali Akbar</creatorcontrib><creatorcontrib>Tran Thi, Thuy Nhien</creatorcontrib><creatorcontrib>Liu, Xiangdong</creatorcontrib><creatorcontrib>Adetula, Adeyinka Abiola</creatorcontrib><creatorcontrib>Zhao, Shuhong</creatorcontrib><title>Transcriptional Profiling of Leucocyte Count Variation from Porcine Peripheral Blood Reveals Differential Gene Expression</title><title>BioMed research international</title><addtitle>Biomed Res Int</addtitle><description>Leucocytes have tremendous health-check importance related to the individual antiviral capacity of pigs and other mammals. However, the molecular mechanism of the immune response of blood leucocytes in pigs is not completely known. This study investigated the leucocyte-count variation before and after poly I:C stimulation in a Duroc–Erhualian F2 population. Pigs with increased and decreased differences in leucocyte counts were coded as increased responder (IR) and decreased responder (DR), respectively. Then, we used microarray technology to compare the gene-expression profiles of both groups of pigs. Transcriptomic analysis identified 129 differentially expressed genes (DEGs) in IR pigs and 136 DEGs in DR pigs. Forty-one common DEGs showed that both groups had similar expression patterns of immune responses. These results illustrated a differential expression in both groups. Furthermore, qPCR experiment was performed to verify the differential-expression profile. Functional annotation of the DEGs indicated that both IR and DR pigs were similar in several biological processes, including innate immune response, and also exhibited distinct differences in biological processes, molecular function, and pathways. These results provided insights into the mechanism underlying the antiviral capacity of pigs. Trial registration number is CAS Registry Number 24939-03-5.</description><subject>Annotations</subject><subject>Antiviral agents</subject><subject>Biological activity</subject><subject>Biomedical research</subject><subject>Biotechnology industry</subject><subject>Blood</subject><subject>Cytokines</subject><subject>Dendritic cells</subject><subject>Direct reduction</subject><subject>DNA microarrays</subject><subject>Fever</subject><subject>Gene expression</subject><subject>Genes</subject><subject>Genetic aspects</subject><subject>Genetic research</subject><subject>Genetic transcription</subject><subject>Hogs</subject><subject>Immune response</subject><subject>Immune system</subject><subject>Infections</subject><subject>Influenza</subject><subject>Infrared radiation</subject><subject>Innate immunity</subject><subject>Laboratory animals</subject><subject>Leukocytes</subject><subject>Peripheral blood</subject><subject>Polyinosinic:polycytidylic 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Profiling of Leucocyte Count Variation from Porcine Peripheral Blood Reveals Differential Gene Expression</title><author>Wang, Haiyan ; Ma, Yunlong ; Li, Xinyun ; Zhu, Mengjin ; Du, Xiaoyong ; Bhuiyan, Ali Akbar ; Tran Thi, Thuy Nhien ; Liu, Xiangdong ; Adetula, Adeyinka Abiola ; Zhao, Shuhong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c499t-56ce70537888c5182c88d0d0ec2d360d42be0c224c6a1c0b963f7b45d9fafe5a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Annotations</topic><topic>Antiviral agents</topic><topic>Biological activity</topic><topic>Biomedical research</topic><topic>Biotechnology industry</topic><topic>Blood</topic><topic>Cytokines</topic><topic>Dendritic cells</topic><topic>Direct reduction</topic><topic>DNA microarrays</topic><topic>Fever</topic><topic>Gene expression</topic><topic>Genes</topic><topic>Genetic aspects</topic><topic>Genetic 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However, the molecular mechanism of the immune response of blood leucocytes in pigs is not completely known. This study investigated the leucocyte-count variation before and after poly I:C stimulation in a Duroc–Erhualian F2 population. Pigs with increased and decreased differences in leucocyte counts were coded as increased responder (IR) and decreased responder (DR), respectively. Then, we used microarray technology to compare the gene-expression profiles of both groups of pigs. Transcriptomic analysis identified 129 differentially expressed genes (DEGs) in IR pigs and 136 DEGs in DR pigs. Forty-one common DEGs showed that both groups had similar expression patterns of immune responses. These results illustrated a differential expression in both groups. Furthermore, qPCR experiment was performed to verify the differential-expression profile. 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| subjects | Annotations Antiviral agents Biological activity Biomedical research Biotechnology industry Blood Cytokines Dendritic cells Direct reduction DNA microarrays Fever Gene expression Genes Genetic aspects Genetic research Genetic transcription Hogs Immune response Immune system Infections Influenza Infrared radiation Innate immunity Laboratory animals Leukocytes Peripheral blood Polyinosinic:polycytidylic acid Proteins Swine Transcription Viral infections Viruses |
| title | Transcriptional Profiling of Leucocyte Count Variation from Porcine Peripheral Blood Reveals Differential Gene Expression |
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