Sodium nitroprusside, a nitric oxide donor, fails to bypass the block of neuronal differentiation in PC12 cells imposed by a dominant negative Ras protein

Nitric oxide (NO) is a mediator of a diverse array of inter- and intracellular signal transduction processes. The aim of the present study was to analyze its possible role as a second messenger in the process of neuronal differentiation of PC12 pheochromocytoma cells. Upon NGF treatment wildtype PC1...

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Veröffentlicht in:	Cellular & molecular biology letters 2012-09, Vol.17 (3), p.323-332
Hauptverfasser:	Bátor, Judit, Varga, Judit, Berta, Gergely, Barbakadze, Tamar, Mikeladze, David, Ramsden, Jeremy, Szeberényi, József
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt protein Animals Cell Differentiation - drug effects Cell Proliferation - drug effects CREB protein Cyclic AMP Response Element-Binding Protein - metabolism Dominant inhibitory Ras protein ERK proteins MAP Kinase Signaling System - drug effects Nerve growth factor Nerve Growth Factor - pharmacology Neuronal differentiation Neurons - drug effects Neurons - metabolism Nitric oxide Nitric Oxide - metabolism Nitric Oxide - pharmacology Nitric Oxide Donors - metabolism Nitric Oxide Donors - pharmacology Nitroprusside - pharmacology p53 protein PC12 Cells Proto-Oncogene Proteins c-akt - metabolism ras Proteins - genetics ras Proteins - metabolism Rats Short Communication Signal Transduction - drug effects Sodium nitroprusside Tumor Suppressor Protein p53 - metabolism
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