Polygenic adaptation and convergent evolution on growth and cardiac genetic pathways in African and Asian rainforest hunter-gatherers

Different human populations facing similar environmental challenges have sometimes evolved convergent biological adaptations, for example, hypoxia resistance at high altitudes and depigmented skin in northern latitudes on separate continents. The “pygmy” phenotype (small adult body size), characteri...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2018-11, Vol.115 (48), p.E11256-E11263
Hauptverfasser:	Bergey, Christina M., Lopez, Marie, Harrison, Genelle F., Patin, Etienne, Cohen, Jacob A., Quintana-Murci, Lluís, Barreiro, Luis B., Perry, George H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acclimatization Adaptation Adaptation, Physiological African Continental Ancestry Group - genetics Amino acid sequence Asian Continental Ancestry Group - genetics Biological evolution Biological Sciences Body size Cardiac muscle Cardiovascular disease Convergence Data processing DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Evolutionary biology Genes Genetics, Population Genomes Growth factors Growth Hormone - genetics Growth Hormone - metabolism Growth hormones Heart - growth & development Heart - physiology Human populations Humans Hunter-gatherers Hypoxia Multifactorial Inheritance Muscles Phenotype Phenotypes PNAS Plus Polygenic inheritance Population genetics Populations Positive selection Proteins Rainforest Rainforests Signatures Skin Transcription Factors - genetics Transcription Factors - metabolism
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