Label-Free Quantitative Proteomics in a Methylmalonyl-CoA Mutase-Silenced Neuroblastoma Cell Line

Methylmalonic acidemias (MMAs) are inborn errors of metabolism due to the deficient activity of methylmalonyl-CoA mutase (MUT). MUT catalyzes the formation of succinyl-CoA from methylmalonyl-CoA, produced from propionyl-CoA catabolism and derived from odd chain fatty acids β-oxidation, cholesterol,...

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Veröffentlicht in:	International journal of molecular sciences 2018-11, Vol.19 (11), p.3580
Hauptverfasser:	Costanzo, Michele, Cevenini, Armando, Marchese, Emanuela, Imperlini, Esther, Raia, Maddalena, Del Vecchio, Luigi, Caterino, Marianna, Ruoppolo, Margherita
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino acids Apoptosis Apoptosis - genetics Apoptosis - physiology Carbohydrate metabolism Carbohydrates Catabolism Cell Line, Tumor Cell Survival - genetics Cell Survival - physiology Cell viability Chain branching Cholesterol Communication Computational Biology Datasets Diabetic ketoacidosis Energy Metabolism - genetics Energy Metabolism - physiology Enzymes Fatty acids Flow Cytometry Homeostasis Humans Hyperammonemia Inborn errors of metabolism Ketoacidosis Ketosis - genetics Ketosis - metabolism Lethargy Lipid metabolism Lipids Liver Mass spectrometry Mass spectroscopy Medical screening Metabolic pathways Metabolism Methylmalonyl-CoA Methylmalonyl-CoA mutase Methylmalonyl-CoA Mutase - genetics Mitochondria Mitochondrial Proteins - genetics Mitochondrial Proteins - metabolism Neuroblastoma Neuroblastoma - genetics Neuroblastoma - metabolism Oxidation Oxidative stress Propionic acid Protein expression Proteins Proteomics Proteomics - methods Quantitative analysis Renal failure RNA, Small Interfering - genetics siRNA Succinyl-CoA Transcription
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