Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases
Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabet...
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| Veröffentlicht in: | International journal of molecular sciences 2018-10, Vol.19 (11), p.3285 |
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| creator | Sonnweber, Thomas Pizzini, Alex Nairz, Manfred Weiss, Günter Tancevski, Ivan |
| description | Lipid and immune pathways are crucial in the pathophysiology of metabolic and cardiovascular disease. Arachidonic acid (AA) and its derivatives link nutrient metabolism to immunity and inflammation, thus holding a key role in the emergence and progression of frequent diseases such as obesity, diabetes, non-alcoholic fatty liver disease, and cardiovascular disease. We herein present a synopsis of AA metabolism in human health, tissue homeostasis, and immunity, and explore the role of the AA metabolome in diverse pathophysiological conditions and diseases. |
| doi_str_mv | 10.3390/ijms19113285 |
| format | Article |
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| subjects | Animals Arachidonic acid Arachidonic Acid - metabolism Atherosclerosis Cardiovascular diseases Cardiovascular Diseases - metabolism Cholesterol - metabolism Diabetes mellitus Disease Eicosanoids - metabolism Enzymes Fatty acids Fatty liver Homeostasis Humans Inflammation Kinases Lipid Metabolism - physiology Lipids Liver diseases Metabolic disorders Metabolites Mortality Non-alcoholic Fatty Liver Disease - metabolism Obesity Obesity - metabolism Oxidation Oxidative stress Review |
| title | Arachidonic Acid Metabolites in Cardiovascular and Metabolic Diseases |
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