Targeting Smoothened as a New Frontier in the Functional Recovery of Central Nervous System Demyelinating Pathologies

Myelin sheaths on vertebrate axons provide protection, vital support and increase the speed of neuronal signals. Myelin degeneration can be caused by viral, autoimmune or genetic diseases. Remyelination is a natural process that restores the myelin sheath and, consequently, neuronal function after a...

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Veröffentlicht in:	International journal of molecular sciences 2018-11, Vol.19 (11), p.3677
Hauptverfasser:	Del Giovane, Alice, Ragnini-Wilson, Antonella
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Axons Cell cycle Cell differentiation Cell division Central nervous system Central Nervous System - parasitology Central Nervous System - pathology Cholesterol - biosynthesis Degeneration Demyelinating Diseases - pathology Demyelinating Diseases - physiopathology Demyelination Genetic disorders Glioma Growth factors Hedgehog protein Humans Ligands Myelin Myelination Neurodegeneration Recovery of Function Review Sheaths Signal Transduction Smoothened Receptor - metabolism Spinal cord Stem cells Stimulators Transcription factors Tumors Vertebrates
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