Invited Commentary: Detecting Individual and Global Horizontal Pleiotropy in Mendelian Randomization—A Job for the Humble Heterogeneity Statistic?

Abstract Mendelian randomization (MR) is gaining in recognition and popularity as a method for strengthening causal inference in epidemiology by utilizing genetic variants as instrumental variables. Concurrently with the explosion in empirical MR studies, there has been the steady production of new...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	American journal of epidemiology 2018-12, Vol.187 (12), p.2681-2685
Hauptverfasser:	Bowden, Jack, Hemani, Gibran, Davey Smith, George
Format:	Artikel
Sprache:	eng
Schlagworte:	Empirical analysis Epidemiology Genetic diversity Genetic variance Heterogeneity Invited Commentaries Mendelian Randomization Analysis Nucleotides Pleiotropy Polymorphism Polymorphism, Single Nucleotide Randomization Regression analysis Single-nucleotide polymorphism Statistical analysis
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!