N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study
A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)...
Gespeichert in:
| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2012-08, Vol.17 (8), p.9413-9420 |
|---|---|
| Hauptverfasser: | , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 9420 |
|---|---|
| container_issue | 8 |
| container_start_page | 9413 |
| container_title | Molecules (Basel, Switzerland) |
| container_volume | 17 |
| creator | Wu, Jian Kang, Shenghong Yuan, Qinkun Luo, Lijun Ma, Juan Shi, Qingcai Yang, Song |
| description | A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed. |
| doi_str_mv | 10.3390/molecules17089413 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6268875</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3323865051</sourcerecordid><originalsourceid>FETCH-LOGICAL-c427t-d724636e5850ae1940aaf4e2d983f4e7b892104d5161100840fe0d456258369e3</originalsourceid><addsrcrecordid>eNplUV1rVDEUDKLY2voDfJGALy2YNt838UEoRa2wqNj6HLI32W5KNlmT3OL12R9uZGup-HQGzsycOQwALwg-YUzj002Ofpyir2TASnPCHoF9wilGDHP9-AHeA89qvcGYEk7EU7BHqZKaSLIPfn1CdVrWFtrUvIMCjeuYS0YSbdc-zXE7l-Dsz5AQO6IXxygnX9_AOqe29jXU1zCk6scWxs6K0HZ0G9oM7bXtiwa_xG4bo4U_5pjrDh4tTo6hTQ5enn2FtU1uPgRPVjZW__xuHoBv799dnV-gxecPH8_PFmjkdGjIDZRLJr1QAltPNMfWrrinTivW57BUmhLMneifEYwVxyuPHReSCsWk9uwAvN35bqflxrvRp1ZsNNsSNrbMJttg_t2ksDbX-dZIKpUaRDd4dWdQ8vfJ12Zu8lRSz2yIYEQPSjHSWWTHGkuutfjV_QWCzZ_izH_Fdc3Lh9HuFX-bYr8B9wSXSw</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1531978831</pqid></control><display><type>article</type><title>N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study</title><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>MEDLINE</source><source>DOAJ Directory of Open Access Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><source>PubMed Central</source><source>Free Full-Text Journals in Chemistry</source><creator>Wu, Jian ; Kang, Shenghong ; Yuan, Qinkun ; Luo, Lijun ; Ma, Juan ; Shi, Qingcai ; Yang, Song</creator><creatorcontrib>Wu, Jian ; Kang, Shenghong ; Yuan, Qinkun ; Luo, Lijun ; Ma, Juan ; Shi, Qingcai ; Yang, Song</creatorcontrib><description>A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules17089413</identifier><identifier>PMID: 22869161</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Alkylation ; Animals ; Bioengineering ; Hydrocarbons ; Insecticides ; Insecticides - chemical synthesis ; Insecticides - chemistry ; Insecticides - pharmacology ; Moths - drug effects ; Pest Control ; Pesticides ; Pyridazines - chemical synthesis ; Pyridazines - chemistry ; Pyridazines - pharmacology ; Structure-Activity Relationship</subject><ispartof>Molecules (Basel, Switzerland), 2012-08, Vol.17 (8), p.9413-9420</ispartof><rights>Copyright MDPI AG 2012</rights><rights>2012 by the authors; licensee MDPI, Basel, Switzerland. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c427t-d724636e5850ae1940aaf4e2d983f4e7b892104d5161100840fe0d456258369e3</citedby><cites>FETCH-LOGICAL-c427t-d724636e5850ae1940aaf4e2d983f4e7b892104d5161100840fe0d456258369e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268875/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268875/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22869161$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Kang, Shenghong</creatorcontrib><creatorcontrib>Yuan, Qinkun</creatorcontrib><creatorcontrib>Luo, Lijun</creatorcontrib><creatorcontrib>Ma, Juan</creatorcontrib><creatorcontrib>Shi, Qingcai</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><title>N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.</description><subject>Alkylation</subject><subject>Animals</subject><subject>Bioengineering</subject><subject>Hydrocarbons</subject><subject>Insecticides</subject><subject>Insecticides - chemical synthesis</subject><subject>Insecticides - chemistry</subject><subject>Insecticides - pharmacology</subject><subject>Moths - drug effects</subject><subject>Pest Control</subject><subject>Pesticides</subject><subject>Pyridazines - chemical synthesis</subject><subject>Pyridazines - chemistry</subject><subject>Pyridazines - pharmacology</subject><subject>Structure-Activity Relationship</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplUV1rVDEUDKLY2voDfJGALy2YNt838UEoRa2wqNj6HLI32W5KNlmT3OL12R9uZGup-HQGzsycOQwALwg-YUzj002Ofpyir2TASnPCHoF9wilGDHP9-AHeA89qvcGYEk7EU7BHqZKaSLIPfn1CdVrWFtrUvIMCjeuYS0YSbdc-zXE7l-Dsz5AQO6IXxygnX9_AOqe29jXU1zCk6scWxs6K0HZ0G9oM7bXtiwa_xG4bo4U_5pjrDh4tTo6hTQ5enn2FtU1uPgRPVjZW__xuHoBv799dnV-gxecPH8_PFmjkdGjIDZRLJr1QAltPNMfWrrinTivW57BUmhLMneifEYwVxyuPHReSCsWk9uwAvN35bqflxrvRp1ZsNNsSNrbMJttg_t2ksDbX-dZIKpUaRDd4dWdQ8vfJ12Zu8lRSz2yIYEQPSjHSWWTHGkuutfjV_QWCzZ_izH_Fdc3Lh9HuFX-bYr8B9wSXSw</recordid><startdate>20120806</startdate><enddate>20120806</enddate><creator>Wu, Jian</creator><creator>Kang, Shenghong</creator><creator>Yuan, Qinkun</creator><creator>Luo, Lijun</creator><creator>Ma, Juan</creator><creator>Shi, Qingcai</creator><creator>Yang, Song</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>5PM</scope></search><sort><creationdate>20120806</creationdate><title>N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study</title><author>Wu, Jian ; Kang, Shenghong ; Yuan, Qinkun ; Luo, Lijun ; Ma, Juan ; Shi, Qingcai ; Yang, Song</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c427t-d724636e5850ae1940aaf4e2d983f4e7b892104d5161100840fe0d456258369e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Alkylation</topic><topic>Animals</topic><topic>Bioengineering</topic><topic>Hydrocarbons</topic><topic>Insecticides</topic><topic>Insecticides - chemical synthesis</topic><topic>Insecticides - chemistry</topic><topic>Insecticides - pharmacology</topic><topic>Moths - drug effects</topic><topic>Pest Control</topic><topic>Pesticides</topic><topic>Pyridazines - chemical synthesis</topic><topic>Pyridazines - chemistry</topic><topic>Pyridazines - pharmacology</topic><topic>Structure-Activity Relationship</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wu, Jian</creatorcontrib><creatorcontrib>Kang, Shenghong</creatorcontrib><creatorcontrib>Yuan, Qinkun</creatorcontrib><creatorcontrib>Luo, Lijun</creatorcontrib><creatorcontrib>Ma, Juan</creatorcontrib><creatorcontrib>Shi, Qingcai</creatorcontrib><creatorcontrib>Yang, Song</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wu, Jian</au><au>Kang, Shenghong</au><au>Yuan, Qinkun</au><au>Luo, Lijun</au><au>Ma, Juan</au><au>Shi, Qingcai</au><au>Yang, Song</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2012-08-06</date><risdate>2012</risdate><volume>17</volume><issue>8</issue><spage>9413</spage><epage>9420</epage><pages>9413-9420</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>A series of N-substituted 5-chloro-6-phenylpyridazin-3(2H)-one derivatives were synthesized based on our previous work; all compounds were characterized by spectral data and tested for in vitro insecticidal activity against Plutella xylostella. The results showed that the synthesized pyridazin-3(2H)-one compounds possessed good insecticidal activities, especially the compounds 4b, 4d, and 4h which showed > 90% activity at 100 mg/L. The structure-activity relationships (SAR) for these compounds were also discussed.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>22869161</pmid><doi>10.3390/molecules17089413</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1420-3049 |
| ispartof | Molecules (Basel, Switzerland), 2012-08, Vol.17 (8), p.9413-9420 |
| issn | 1420-3049 1420-3049 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6268875 |
| source | MDPI - Multidisciplinary Digital Publishing Institute; MEDLINE; DOAJ Directory of Open Access Journals; EZB-FREE-00999 freely available EZB journals; PubMed Central; Free Full-Text Journals in Chemistry |
| subjects | Alkylation Animals Bioengineering Hydrocarbons Insecticides Insecticides - chemical synthesis Insecticides - chemistry Insecticides - pharmacology Moths - drug effects Pest Control Pesticides Pyridazines - chemical synthesis Pyridazines - chemistry Pyridazines - pharmacology Structure-Activity Relationship |
| title | N-substituted 5-chloro-6-phenylpyridazin-3(2H)-ones: synthesis, insecticidal activity against Plutella xylostella (L.) and SAR study |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-07T03%3A43%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=N-substituted%205-chloro-6-phenylpyridazin-3(2H)-ones:%20synthesis,%20insecticidal%20activity%20against%20Plutella%20xylostella%20(L.)%20and%20SAR%20study&rft.jtitle=Molecules%20(Basel,%20Switzerland)&rft.au=Wu,%20Jian&rft.date=2012-08-06&rft.volume=17&rft.issue=8&rft.spage=9413&rft.epage=9420&rft.pages=9413-9420&rft.issn=1420-3049&rft.eissn=1420-3049&rft_id=info:doi/10.3390/molecules17089413&rft_dat=%3Cproquest_pubme%3E3323865051%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1531978831&rft_id=info:pmid/22869161&rfr_iscdi=true |