Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450 system in male rats
We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P₄₅₀, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleoti...
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| Veröffentlicht in: | Molecules (Basel, Switzerland) Switzerland), 2012-07, Vol.17 (7), p.8255-8275 |
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| creator | Hassan, Hammed H A M El-Banna, Sabah G Elhusseiny, Amel F Mansour, El-Sayed M E |
| description | We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P₄₅₀, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl₄ on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl₄ decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl₃) upon the liver through inhibition of the cytochrome P₄₅₀ system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens. |
| doi_str_mv | 10.3390/molecules17078255 |
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Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl₄ on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl₄ decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl₃) upon the liver through inhibition of the cytochrome P₄₅₀ system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.</description><identifier>ISSN: 1420-3049</identifier><identifier>EISSN: 1420-3049</identifier><identifier>DOI: 10.3390/molecules17078255</identifier><identifier>PMID: 22781439</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Amides - chemical synthesis ; Amides - chemistry ; Amides - pharmacology ; Animals ; Antioxidants ; Antioxidants - pharmacology ; Benzamides - chemical synthesis ; Benzamides - chemistry ; Benzamides - pharmacology ; Carbon ; Carcinogens ; Chemistry ; Cytochrome ; Cytochrome P-450 Enzyme System - metabolism ; Enzymes ; Free radicals ; Hydrogen Bonding - drug effects ; Kinetics ; Liver ; Liver - drug effects ; Liver - enzymology ; Male ; Metabolism ; Nanoparticles ; Nanoparticles - chemistry ; Nanoparticles - ultrastructure ; Oxidation ; Oxidation-Reduction - drug effects ; Polymers - chemical synthesis ; Polymers - chemistry ; Polymers - pharmacology ; Rats ; Rats, Sprague-Dawley ; Solubility - drug effects ; Spectroscopy, Fourier Transform Infrared ; Temperature ; Thiobarbituric Acid Reactive Substances - metabolism ; Valine - analogs & derivatives ; Valine - chemistry ; Viscosity - drug effects</subject><ispartof>Molecules (Basel, Switzerland), 2012-07, Vol.17 (7), p.8255-8275</ispartof><rights>Copyright MDPI AG 2012</rights><rights>2012 by the authors; licensee MDPI, Basel, Switzerland. 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2725-cdc604599b4539e8476c5ed585634991a694635c2e6fa1d770deabf7434ba8d93</citedby><cites>FETCH-LOGICAL-c2725-cdc604599b4539e8476c5ed585634991a694635c2e6fa1d770deabf7434ba8d93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268142/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6268142/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,864,885,27922,27923,53789,53791</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22781439$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hassan, Hammed H A M</creatorcontrib><creatorcontrib>El-Banna, Sabah G</creatorcontrib><creatorcontrib>Elhusseiny, Amel F</creatorcontrib><creatorcontrib>Mansour, El-Sayed M E</creatorcontrib><title>Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450 system in male rats</title><title>Molecules (Basel, Switzerland)</title><addtitle>Molecules</addtitle><description>We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P₄₅₀, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl₄ on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl₄ decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl₃) upon the liver through inhibition of the cytochrome P₄₅₀ system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.</description><subject>Amides - chemical synthesis</subject><subject>Amides - chemistry</subject><subject>Amides - pharmacology</subject><subject>Animals</subject><subject>Antioxidants</subject><subject>Antioxidants - pharmacology</subject><subject>Benzamides - chemical synthesis</subject><subject>Benzamides - chemistry</subject><subject>Benzamides - pharmacology</subject><subject>Carbon</subject><subject>Carcinogens</subject><subject>Chemistry</subject><subject>Cytochrome</subject><subject>Cytochrome P-450 Enzyme System - metabolism</subject><subject>Enzymes</subject><subject>Free radicals</subject><subject>Hydrogen Bonding - drug effects</subject><subject>Kinetics</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Liver - enzymology</subject><subject>Male</subject><subject>Metabolism</subject><subject>Nanoparticles</subject><subject>Nanoparticles - chemistry</subject><subject>Nanoparticles - ultrastructure</subject><subject>Oxidation</subject><subject>Oxidation-Reduction - drug effects</subject><subject>Polymers - chemical synthesis</subject><subject>Polymers - chemistry</subject><subject>Polymers - pharmacology</subject><subject>Rats</subject><subject>Rats, Sprague-Dawley</subject><subject>Solubility - drug effects</subject><subject>Spectroscopy, Fourier Transform Infrared</subject><subject>Temperature</subject><subject>Thiobarbituric Acid Reactive Substances - metabolism</subject><subject>Valine - analogs & derivatives</subject><subject>Valine - chemistry</subject><subject>Viscosity - drug effects</subject><issn>1420-3049</issn><issn>1420-3049</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNplUctu1TAQjRCIlsIHsEGWWAf8jOMNUlXxkipgAWtrrj1pXCV2sH0vzZ_wuaQPqiJWM9Kcl-Y0zUtG3whh6Ns5Tej2Examqe65Uo-aYyY5bQWV5vGD_ah5VsolpZxJpp42R5zrnklhjpvfp7GGdBU8xErA1XAIdSVpIBF_EcgwB48kQkwL5Brc5kVcihVCDPGCZPTpqr2hIfnSLmMdYUrrRA4whYhkTgFr2DghkjoiGXGBTYW4tSY35jQj-SYVJWUtFedr1AwTkgy1PG-eDDAVfHE3T5ofH95_P_vUnn_9-Pns9Lx1XHPVOu86KpUxO6mEwV7qzin0qledkMYw6IzshHIcuwGY15p6hN2gpZA76L0RJ827W91lv5vRO4w1w2SXHGbIq00Q7L-XGEZ7kQ624932Q74JvL4TyOnnHku1l2mf45bZMiWY0aq_QbFblMuplIzDvQOj9rpM-1-ZG-fVw2j3jL_tiT_e7aEm</recordid><startdate>20120710</startdate><enddate>20120710</enddate><creator>Hassan, Hammed H A M</creator><creator>El-Banna, Sabah G</creator><creator>Elhusseiny, Amel F</creator><creator>Mansour, El-Sayed M E</creator><general>MDPI AG</general><general>MDPI</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>5PM</scope></search><sort><creationdate>20120710</creationdate><title>Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450 system in male rats</title><author>Hassan, Hammed H A M ; El-Banna, Sabah G ; Elhusseiny, Amel F ; Mansour, El-Sayed M E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2725-cdc604599b4539e8476c5ed585634991a694635c2e6fa1d770deabf7434ba8d93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Amides - chemical synthesis</topic><topic>Amides - chemistry</topic><topic>Amides - pharmacology</topic><topic>Animals</topic><topic>Antioxidants</topic><topic>Antioxidants - pharmacology</topic><topic>Benzamides - chemical synthesis</topic><topic>Benzamides - chemistry</topic><topic>Benzamides - pharmacology</topic><topic>Carbon</topic><topic>Carcinogens</topic><topic>Chemistry</topic><topic>Cytochrome</topic><topic>Cytochrome P-450 Enzyme System - metabolism</topic><topic>Enzymes</topic><topic>Free radicals</topic><topic>Hydrogen Bonding - drug effects</topic><topic>Kinetics</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Liver - enzymology</topic><topic>Male</topic><topic>Metabolism</topic><topic>Nanoparticles</topic><topic>Nanoparticles - chemistry</topic><topic>Nanoparticles - ultrastructure</topic><topic>Oxidation</topic><topic>Oxidation-Reduction - drug effects</topic><topic>Polymers - chemical synthesis</topic><topic>Polymers - chemistry</topic><topic>Polymers - pharmacology</topic><topic>Rats</topic><topic>Rats, Sprague-Dawley</topic><topic>Solubility - drug effects</topic><topic>Spectroscopy, Fourier Transform Infrared</topic><topic>Temperature</topic><topic>Thiobarbituric Acid Reactive Substances - metabolism</topic><topic>Valine - analogs & derivatives</topic><topic>Valine - chemistry</topic><topic>Viscosity - drug effects</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hassan, Hammed H A M</creatorcontrib><creatorcontrib>El-Banna, Sabah G</creatorcontrib><creatorcontrib>Elhusseiny, Amel F</creatorcontrib><creatorcontrib>Mansour, El-Sayed M E</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Molecules (Basel, Switzerland)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hassan, Hammed H A M</au><au>El-Banna, Sabah G</au><au>Elhusseiny, Amel F</au><au>Mansour, El-Sayed M E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450 system in male rats</atitle><jtitle>Molecules (Basel, Switzerland)</jtitle><addtitle>Molecules</addtitle><date>2012-07-10</date><risdate>2012</risdate><volume>17</volume><issue>7</issue><spage>8255</spage><epage>8275</epage><pages>8255-8275</pages><issn>1420-3049</issn><eissn>1420-3049</eissn><abstract>We report the synthesis of aramide nanoparticles containing a chiral N-phthaloyl valine moiety and their antioxidant activities on hepatic contents of cytochrome P₄₅₀, amidopyrene N-demethylase, aniline-4-hyroxylase and induced the hepatic content of cytochrome b5 and nicotinamide adenine dinucleotide phosphate (NADPH) cytochrome C-reductase. Polymers were obtained as well-separated spherical nanoparticles while highly aggregated particles via H-bonding organization of the aramide-containing pyridine led to a thin layer formation. The effects of the nanoparticles and CCl₄ on enzyme activities and thiobarbituric acid reactive substances (TBARS) levels of male rat liver were studied. Pretreatments of rats with the polyamides prior to the administration of CCl₄ decreased the hepatic content of the tested enzymes. Doses reduced the toxic effects exerted by (•CCl₃) upon the liver through inhibition of the cytochrome P₄₅₀ system. Inhibition of such metabolizing enzymes could reduce the carcinogenic effects of chemical carcinogens.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>22781439</pmid><doi>10.3390/molecules17078255</doi><tpages>21</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Amides - chemical synthesis Amides - chemistry Amides - pharmacology Animals Antioxidants Antioxidants - pharmacology Benzamides - chemical synthesis Benzamides - chemistry Benzamides - pharmacology Carbon Carcinogens Chemistry Cytochrome Cytochrome P-450 Enzyme System - metabolism Enzymes Free radicals Hydrogen Bonding - drug effects Kinetics Liver Liver - drug effects Liver - enzymology Male Metabolism Nanoparticles Nanoparticles - chemistry Nanoparticles - ultrastructure Oxidation Oxidation-Reduction - drug effects Polymers - chemical synthesis Polymers - chemistry Polymers - pharmacology Rats Rats, Sprague-Dawley Solubility - drug effects Spectroscopy, Fourier Transform Infrared Temperature Thiobarbituric Acid Reactive Substances - metabolism Valine - analogs & derivatives Valine - chemistry Viscosity - drug effects |
| title | Antioxidant activity of new aramide nanoparticles containing redox-active N-phthaloyl valine moieties in the hepatic cytochrome P450 system in male rats |
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