Gestational chronodisruption leads to persistent changes in the rat fetal and adult adrenal clock and function

Key points Light at night is essential to a 24/7 society, but it has negative consequences on health. Basically, light at night induces an alteration of our biological clocks, known as chronodisruption, with effects even when this occurs during pregnancy. Here we explored the developmental impact of...

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Veröffentlicht in:	The Journal of physiology 2018-12, Vol.596 (23), p.5839-5857
Hauptverfasser:	Salazar, E. R., Richter, H. G., Spichiger, C., Mendez, N., Halabi, D., Vergara, K., Alonso, I. P., Corvalán, F. A., Azpeleta, C., Seron‐Ferre, M., Torres‐Farfan, C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenal glands Adrenal Glands - physiology Animals Behavior, Animal Biological clocks Chronic illnesses Circadian Clocks - physiology Clock gene Corticosterone DNA Methylation Female Fetal programming of adult disease Fetus - physiology Fetuses Functional genomics Gene expression Gene regulation Gestation Inflammation Lipid metabolism Long-term effects Male Offspring Peripheral clock Pregnancy Rats, Sprague-Dawley Research Paper Research papers Steroid hormones Steroidogenic pathway Stress‐anxiety Transcriptome
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