Tumor-derived microRNAs induce myeloid suppressor cells and predict immunotherapy resistance in melanoma

The accrual of myeloid-derived suppressor cells (MDSCs) represents a major obstacle to effective immunotherapy in cancer patients, but the mechanisms underlying this process in the human setting remain elusive. Here, we describe a set of microRNAs (miR-146a, miR-155, miR-125b, miR-100, let-7e, miR-1...

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Veröffentlicht in:	The Journal of clinical investigation 2018-12, Vol.128 (12), p.5505-5516
Hauptverfasser:	Huber, Veronica, Vallacchi, Viviana, Fleming, Viktor, Hu, Xiaoying, Cova, Agata, Dugo, Matteo, Shahaj, Eriomina, Sulsenti, Roberta, Vergani, Elisabetta, Filipazzi, Paola, De Laurentiis, Angela, Lalli, Luca, Di Guardo, Lorenza, Patuzzo, Roberto, Vergani, Barbara, Casiraghi, Elena, Cossa, Mara, Gualeni, Ambra, Bollati, Valentina, Arienti, Flavio, De Braud, Filippo, Mariani, Luigi, Villa, Antonello, Altevogt, Peter, Umansky, Viktor, Rodolfo, Monica, Rivoltini, Licia
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis Angiogenesis Apoptosis Biomedical research Cancer Cancer patients Cancer treatment Care and treatment CD14 antigen Cell death Cell growth CTLA-4 protein Genomes Genomics Genotype & phenotype Granulocytes Histocompatibility antigen HLA Immune checkpoint inhibitors Immunotherapy Infection Lymphocytes Medical prognosis Melanoma MicroRNA MicroRNAs miRNA Monocytes Patients PD-1 protein Proteins Skin cancer Suppressor cells Transcription Transfection Treatment outcome Tumors
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