Dynamin impacts homology-directed repair and breast cancer response to chemotherapy

After the initial responsiveness of triple-negative breast cancers (TNBCs) to chemotherapy, they often recur as chemotherapy-resistant tumors, and this has been associated with upregulated homology-directed repair (HDR). Thus, inhibitors of HDR could be a useful adjunct to chemotherapy treatment of...

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Veröffentlicht in:	The Journal of clinical investigation 2018-12, Vol.128 (12), p.5307-5321
Hauptverfasser:	Chernikova, Sophia B, Nguyen, Rochelle B, Truong, Jessica T, Mello, Stephano S, Stafford, Jason H, Hay, Michael P, Olson, Andrew, Solow-Cordero, David E, Wood, Douglas J, Henry, Solomon, von Eyben, Rie, Deng, Lei, Gephart, Melanie Hayden, Aroumougame, Asaithamby, Wiese, Claudia, Game, John C, Győrffy, Balázs, Brown, J Martin
Format:	Artikel
Sprache:	eng
Schlagworte:	Anemia Animals Antineoplastic agents Antineoplastic Agents - pharmacology Biomedical research Breast cancer Cancer therapies Cancer treatment Care and treatment Chemotherapy CHO Cells Cricetulus Defects Deoxyribonucleic acid DNA DNA damage DNA methylation DNA repair Drug resistance Dynamin Dynamin II Dynamins - genetics Dynamins - metabolism Enzymes Estrogens Female Genomes High-throughput screening (Biochemical assaying) Homology Humans Ionizing radiation Medical prognosis Metastasis Mice Mice, Nude Mutation Phenols (Class of compounds) Proteins Recombinational DNA Repair Triple negative breast cancer Triple Negative Breast Neoplasms - drug therapy Triple Negative Breast Neoplasms - enzymology Triple Negative Breast Neoplasms - genetics Triple Negative Breast Neoplasms - pathology Tumors Xenograft Model Antitumor Assays
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