Rho-kinase/AMPK axis regulates hepatic lipogenesis during overnutrition

Obesity is a major risk factor for developing nonalcoholic fatty liver disease (NAFLD). NAFLD is the most common form of chronic liver disease and is closely associated with insulin resistance, ultimately leading to cirrhosis and hepatocellular carcinoma. However, knowledge of the intracellular regu...

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Veröffentlicht in:	The Journal of clinical investigation 2018-12, Vol.128 (12), p.5335-5350
Hauptverfasser:	Huang, Hu, Lee, Seung-Hwan, Sousa-Lima, Inês, Kim, Sang Soo, Hwang, Won Min, Dagon, Yossi, Yang, Won-Mo, Cho, Sungman, Kang, Min-Cheol, Seo, Ji A, Shibata, Munehiko, Cho, Hyunsoo, Belew, Getachew Debas, Bhin, Jinhyuk, Desai, Bhavna N, Ryu, Min Jeong, Shong, Minho, Li, Peixin, Meng, Hua, Chung, Byung-Hong, Hwang, Daehee, Kim, Min Seon, Park, Kyong Soo, Macedo, Maria Paula, White, Morris, Jones, John, Kim, Young-Bum
Format:	Artikel
Sprache:	eng
Schlagworte:	Adipose tissue AMP-Activated Protein Kinases - genetics AMP-Activated Protein Kinases - metabolism Animals Biochemistry Biomedical research Cannabinoids Carcinoma Cell adhesion & migration Cellular signal transduction Cirrhosis Complications and side effects Diabetes Diabetes mellitus Energy expenditure Fatty liver Gene expression Genes Genetic aspects Glucose Hepatocellular carcinoma High fat diet Homeostasis Humans Hyperglycemia Insulin Insulin resistance Insulin Resistance - genetics Kinases Lipids Lipogenesis Liver - metabolism Liver - pathology Liver cirrhosis Liver diseases Male Metabolic disorders Metformin Mice Mice, Knockout Mice, Obese Mitochondrial DNA Non-alcoholic Fatty Liver Disease - enzymology Non-alcoholic Fatty Liver Disease - etiology Non-alcoholic Fatty Liver Disease - genetics Non-alcoholic Fatty Liver Disease - pathology Obesity Obesity - complications Obesity - genetics Obesity - metabolism Obesity - pathology Overnutrition Overnutrition - complications Overnutrition - enzymology Overnutrition - genetics Overnutrition - pathology Physiology Proteins Rho-associated kinase rho-Associated Kinases - genetics rho-Associated Kinases - metabolism Risk factors Rodents Signal Transduction Steatosis Type 2 diabetes
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