Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function
The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date,...
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| Veröffentlicht in: | British journal of nutrition 2018-11, Vol.120 (10), p.1159-1170 |
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| creator | Xu, Jiayi Bartz, Traci M. Chittoor, Geetha Eiriksdottir, Gudny Manichaikul, Ani W. Sun, Fangui Terzikhan, Natalie Zhou, Xia Booth, Sarah L. Brusselle, Guy G. de Boer, Ian H. Fornage, Myriam Frazier-Wood, Alexis C. Graff, Mariaelisa Gudnason, Vilmundur Harris, Tamara B. Hofman, Albert Hou, Ruixue Houston, Denise K. Jacobs, David R. Kritchevsky, Stephen B. Latourelle, Jeanne Lemaitre, Rozenn N. Lutsey, Pamela L. O’Connor, George Oelsner, Elizabeth C. Pankow, James S. Psaty, Bruce M. Rohde, Rebecca R. Rich, Stephen S. Rotter, Jerome I. Smith, Lewis J. Stricker, Bruno H. Voruganti, V. Saroja Wang, Thomas J. Zillikens, M. Carola Barr, R. Graham Dupuis, Josée Gharib, Sina A. Lahousse, Lies London, Stephanie J. North, Kari E. Smith, Albert V. Steffen, Lyn M. Hancock, Dana B. Cassano, Patricia A. |
| description | The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P |
| doi_str_mv | 10.1017/S0007114518002180 |
| format | Article |
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race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (P
race difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.</description><identifier>ISSN: 0007-1145</identifier><identifier>ISSN: 1475-2662</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S0007114518002180</identifier><identifier>PMID: 30205856</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>25-Hydroxyvitamin D ; Adult ; African Americans ; Aged ; Aging ; Airway management ; Atherosclerosis ; Black People ; Cancer ; Chronic obstructive pulmonary disease ; Consortia ; Cross-Sectional Studies ; Data processing ; Dietary Surveys and Nutritional Epidemiology ; Epidemiology ; Female ; Forced Expiratory Volume ; Genome, Human ; Heart ; Heart - physiology ; Heart Diseases - genetics ; Heart Diseases - prevention & control ; Humans ; Lung - physiology ; Lung Diseases - genetics ; Lung Diseases - prevention & control ; Male ; Males ; Medical screening ; Meta-analysis ; Middle Aged ; Molecular Epidemiology ; Prospective Studies ; Pulmonary functions ; Regression Analysis ; Respiratory function ; Respiratory Function Tests ; Smoking ; Vital Capacity ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood ; White People ; Young adults</subject><ispartof>British journal of nutrition, 2018-11, Vol.120 (10), p.1159-1170</ispartof><rights>The Authors 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c471t-b67c9896f41c4710bd8b24db44aea014ebbe29edfb5540e931751905265213c43</citedby><cites>FETCH-LOGICAL-c471t-b67c9896f41c4710bd8b24db44aea014ebbe29edfb5540e931751905265213c43</cites><orcidid>0000-0002-7232-0543</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S0007114518002180/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,230,314,776,780,881,27903,27904,55607</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30205856$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Jiayi</creatorcontrib><creatorcontrib>Bartz, Traci M.</creatorcontrib><creatorcontrib>Chittoor, Geetha</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Manichaikul, Ani W.</creatorcontrib><creatorcontrib>Sun, Fangui</creatorcontrib><creatorcontrib>Terzikhan, Natalie</creatorcontrib><creatorcontrib>Zhou, Xia</creatorcontrib><creatorcontrib>Booth, Sarah L.</creatorcontrib><creatorcontrib>Brusselle, Guy G.</creatorcontrib><creatorcontrib>de Boer, Ian H.</creatorcontrib><creatorcontrib>Fornage, Myriam</creatorcontrib><creatorcontrib>Frazier-Wood, Alexis C.</creatorcontrib><creatorcontrib>Graff, Mariaelisa</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Harris, Tamara B.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Hou, Ruixue</creatorcontrib><creatorcontrib>Houston, Denise K.</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Latourelle, Jeanne</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N.</creatorcontrib><creatorcontrib>Lutsey, Pamela L.</creatorcontrib><creatorcontrib>O’Connor, George</creatorcontrib><creatorcontrib>Oelsner, Elizabeth C.</creatorcontrib><creatorcontrib>Pankow, James S.</creatorcontrib><creatorcontrib>Psaty, Bruce M.</creatorcontrib><creatorcontrib>Rohde, Rebecca R.</creatorcontrib><creatorcontrib>Rich, Stephen S.</creatorcontrib><creatorcontrib>Rotter, Jerome I.</creatorcontrib><creatorcontrib>Smith, Lewis J.</creatorcontrib><creatorcontrib>Stricker, Bruno H.</creatorcontrib><creatorcontrib>Voruganti, V. Saroja</creatorcontrib><creatorcontrib>Wang, Thomas J.</creatorcontrib><creatorcontrib>Zillikens, M. Carola</creatorcontrib><creatorcontrib>Barr, R. Graham</creatorcontrib><creatorcontrib>Dupuis, Josée</creatorcontrib><creatorcontrib>Gharib, Sina A.</creatorcontrib><creatorcontrib>Lahousse, Lies</creatorcontrib><creatorcontrib>London, Stephanie J.</creatorcontrib><creatorcontrib>North, Kari E.</creatorcontrib><creatorcontrib>Smith, Albert V.</creatorcontrib><creatorcontrib>Steffen, Lyn M.</creatorcontrib><creatorcontrib>Hancock, Dana B.</creatorcontrib><creatorcontrib>Cassano, Patricia A.</creatorcontrib><title>Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P
race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (P
race difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.</description><subject>25-Hydroxyvitamin D</subject><subject>Adult</subject><subject>African Americans</subject><subject>Aged</subject><subject>Aging</subject><subject>Airway management</subject><subject>Atherosclerosis</subject><subject>Black People</subject><subject>Cancer</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Consortia</subject><subject>Cross-Sectional Studies</subject><subject>Data processing</subject><subject>Dietary Surveys and Nutritional Epidemiology</subject><subject>Epidemiology</subject><subject>Female</subject><subject>Forced Expiratory Volume</subject><subject>Genome, Human</subject><subject>Heart</subject><subject>Heart - physiology</subject><subject>Heart Diseases - genetics</subject><subject>Heart Diseases - prevention & control</subject><subject>Humans</subject><subject>Lung - physiology</subject><subject>Lung Diseases - genetics</subject><subject>Lung Diseases - prevention & control</subject><subject>Male</subject><subject>Males</subject><subject>Medical screening</subject><subject>Meta-analysis</subject><subject>Middle Aged</subject><subject>Molecular Epidemiology</subject><subject>Prospective Studies</subject><subject>Pulmonary functions</subject><subject>Regression Analysis</subject><subject>Respiratory function</subject><subject>Respiratory Function Tests</subject><subject>Smoking</subject><subject>Vital Capacity</subject><subject>Vitamin D</subject><subject>Vitamin D - analogs & derivatives</subject><subject>Vitamin D - blood</subject><subject>White People</subject><subject>Young adults</subject><issn>0007-1145</issn><issn>1475-2662</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1ks2O0zAQgC0EYsvCA3BBlrgsh4DHsfNzQapKaZEWIS1wjhxnknqV2MVOuuqD8X44u2X5ExePPPP581geQp4Dew0M8jefGWM5gJBQMMbj8oAsQOQy4VnGH5LFXE7m-hl5EsJ13BbAysfkLGWcyUJmC_L9I44qUVb1x2ACVdq7EOjK7ZwfA22dp1tUfqTKNnTZGdvRKwwxo3fUWLpB6waj6XpvGhyM6113pBer7fJqs35FtbMhasw00L13h4gEinOwGm_VylIVgtNGjcZZ6loa0Ef6YEY1RP07emPGHd1P_eCs8kfaTlbP6FPyqFV9wGeneE6-vl9_WW2Ty0-bD6vlZaJFDmNSZ7kuizJrBcwJVjdFzUVTC6FQMRBY18hLbNpaSsGwTCGXUDLJM8kh1SI9J2_vvPupHrDRaEev-mrvzRDbqZwy1Z8Va3ZV5w5VxrMoY1FwcRJ4923CMFaDCRr7Xll0U6g4MF5yngFE9OVf6LWbfPyYmUqZFCBEHim4o24_ymN73wywah6K6p-hiGde_P6K-xM_pyAC6UmqhtqbpsNfd_9f-wNrw8Pd</recordid><startdate>20181128</startdate><enddate>20181128</enddate><creator>Xu, Jiayi</creator><creator>Bartz, Traci M.</creator><creator>Chittoor, Geetha</creator><creator>Eiriksdottir, Gudny</creator><creator>Manichaikul, Ani W.</creator><creator>Sun, Fangui</creator><creator>Terzikhan, Natalie</creator><creator>Zhou, Xia</creator><creator>Booth, Sarah L.</creator><creator>Brusselle, Guy G.</creator><creator>de Boer, Ian H.</creator><creator>Fornage, Myriam</creator><creator>Frazier-Wood, Alexis C.</creator><creator>Graff, Mariaelisa</creator><creator>Gudnason, Vilmundur</creator><creator>Harris, Tamara B.</creator><creator>Hofman, Albert</creator><creator>Hou, Ruixue</creator><creator>Houston, Denise K.</creator><creator>Jacobs, David R.</creator><creator>Kritchevsky, Stephen B.</creator><creator>Latourelle, Jeanne</creator><creator>Lemaitre, Rozenn N.</creator><creator>Lutsey, Pamela L.</creator><creator>O’Connor, George</creator><creator>Oelsner, Elizabeth C.</creator><creator>Pankow, James S.</creator><creator>Psaty, Bruce M.</creator><creator>Rohde, Rebecca R.</creator><creator>Rich, Stephen S.</creator><creator>Rotter, Jerome I.</creator><creator>Smith, Lewis J.</creator><creator>Stricker, Bruno H.</creator><creator>Voruganti, V. 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Graham</creator><creator>Dupuis, Josée</creator><creator>Gharib, Sina A.</creator><creator>Lahousse, Lies</creator><creator>London, Stephanie J.</creator><creator>North, Kari E.</creator><creator>Smith, Albert V.</creator><creator>Steffen, Lyn M.</creator><creator>Hancock, Dana B.</creator><creator>Cassano, Patricia A.</creator><general>Cambridge University Press</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7T5</scope><scope>7X2</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8C1</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AEUYN</scope><scope>AFKRA</scope><scope>AN0</scope><scope>ATCPS</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>M0K</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-7232-0543</orcidid></search><sort><creationdate>20181128</creationdate><title>Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function</title><author>Xu, Jiayi ; Bartz, Traci M. ; Chittoor, Geetha ; Eiriksdottir, Gudny ; Manichaikul, Ani W. ; Sun, Fangui ; Terzikhan, Natalie ; Zhou, Xia ; Booth, Sarah L. ; Brusselle, Guy G. ; de Boer, Ian H. ; Fornage, Myriam ; Frazier-Wood, Alexis C. ; Graff, Mariaelisa ; Gudnason, Vilmundur ; Harris, Tamara B. ; Hofman, Albert ; Hou, Ruixue ; Houston, Denise K. ; Jacobs, David R. ; Kritchevsky, Stephen B. ; Latourelle, Jeanne ; Lemaitre, Rozenn N. ; Lutsey, Pamela L. ; O’Connor, George ; Oelsner, Elizabeth C. ; Pankow, James S. ; Psaty, Bruce M. ; Rohde, Rebecca R. ; Rich, Stephen S. ; Rotter, Jerome I. ; Smith, Lewis J. ; Stricker, Bruno H. ; Voruganti, V. Saroja ; Wang, Thomas J. ; Zillikens, M. Carola ; Barr, R. Graham ; Dupuis, Josée ; Gharib, Sina A. ; Lahousse, Lies ; London, Stephanie J. ; North, Kari E. ; Smith, Albert V. ; Steffen, Lyn M. ; Hancock, Dana B. ; Cassano, Patricia A.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c471t-b67c9896f41c4710bd8b24db44aea014ebbe29edfb5540e931751905265213c43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>25-Hydroxyvitamin D</topic><topic>Adult</topic><topic>African Americans</topic><topic>Aged</topic><topic>Aging</topic><topic>Airway management</topic><topic>Atherosclerosis</topic><topic>Black People</topic><topic>Cancer</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Consortia</topic><topic>Cross-Sectional Studies</topic><topic>Data processing</topic><topic>Dietary Surveys and Nutritional Epidemiology</topic><topic>Epidemiology</topic><topic>Female</topic><topic>Forced Expiratory Volume</topic><topic>Genome, Human</topic><topic>Heart</topic><topic>Heart - physiology</topic><topic>Heart Diseases - genetics</topic><topic>Heart Diseases - prevention & control</topic><topic>Humans</topic><topic>Lung - physiology</topic><topic>Lung Diseases - genetics</topic><topic>Lung Diseases - prevention & control</topic><topic>Male</topic><topic>Males</topic><topic>Medical screening</topic><topic>Meta-analysis</topic><topic>Middle Aged</topic><topic>Molecular Epidemiology</topic><topic>Prospective Studies</topic><topic>Pulmonary functions</topic><topic>Regression Analysis</topic><topic>Respiratory function</topic><topic>Respiratory Function Tests</topic><topic>Smoking</topic><topic>Vital Capacity</topic><topic>Vitamin D</topic><topic>Vitamin D - analogs & derivatives</topic><topic>Vitamin D - blood</topic><topic>White People</topic><topic>Young adults</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Jiayi</creatorcontrib><creatorcontrib>Bartz, Traci M.</creatorcontrib><creatorcontrib>Chittoor, Geetha</creatorcontrib><creatorcontrib>Eiriksdottir, Gudny</creatorcontrib><creatorcontrib>Manichaikul, Ani W.</creatorcontrib><creatorcontrib>Sun, Fangui</creatorcontrib><creatorcontrib>Terzikhan, Natalie</creatorcontrib><creatorcontrib>Zhou, Xia</creatorcontrib><creatorcontrib>Booth, Sarah L.</creatorcontrib><creatorcontrib>Brusselle, Guy G.</creatorcontrib><creatorcontrib>de Boer, Ian H.</creatorcontrib><creatorcontrib>Fornage, Myriam</creatorcontrib><creatorcontrib>Frazier-Wood, Alexis C.</creatorcontrib><creatorcontrib>Graff, Mariaelisa</creatorcontrib><creatorcontrib>Gudnason, Vilmundur</creatorcontrib><creatorcontrib>Harris, Tamara B.</creatorcontrib><creatorcontrib>Hofman, Albert</creatorcontrib><creatorcontrib>Hou, Ruixue</creatorcontrib><creatorcontrib>Houston, Denise K.</creatorcontrib><creatorcontrib>Jacobs, David R.</creatorcontrib><creatorcontrib>Kritchevsky, Stephen B.</creatorcontrib><creatorcontrib>Latourelle, Jeanne</creatorcontrib><creatorcontrib>Lemaitre, Rozenn N.</creatorcontrib><creatorcontrib>Lutsey, Pamela L.</creatorcontrib><creatorcontrib>O’Connor, George</creatorcontrib><creatorcontrib>Oelsner, Elizabeth C.</creatorcontrib><creatorcontrib>Pankow, James S.</creatorcontrib><creatorcontrib>Psaty, Bruce M.</creatorcontrib><creatorcontrib>Rohde, Rebecca R.</creatorcontrib><creatorcontrib>Rich, Stephen S.</creatorcontrib><creatorcontrib>Rotter, Jerome I.</creatorcontrib><creatorcontrib>Smith, Lewis J.</creatorcontrib><creatorcontrib>Stricker, Bruno H.</creatorcontrib><creatorcontrib>Voruganti, V. Saroja</creatorcontrib><creatorcontrib>Wang, Thomas J.</creatorcontrib><creatorcontrib>Zillikens, M. Carola</creatorcontrib><creatorcontrib>Barr, R. Graham</creatorcontrib><creatorcontrib>Dupuis, Josée</creatorcontrib><creatorcontrib>Gharib, Sina A.</creatorcontrib><creatorcontrib>Lahousse, Lies</creatorcontrib><creatorcontrib>London, Stephanie J.</creatorcontrib><creatorcontrib>North, Kari E.</creatorcontrib><creatorcontrib>Smith, Albert V.</creatorcontrib><creatorcontrib>Steffen, Lyn M.</creatorcontrib><creatorcontrib>Hancock, Dana B.</creatorcontrib><creatorcontrib>Cassano, Patricia A.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Nursing and Allied Health Journals</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Jiayi</au><au>Bartz, Traci M.</au><au>Chittoor, Geetha</au><au>Eiriksdottir, Gudny</au><au>Manichaikul, Ani W.</au><au>Sun, Fangui</au><au>Terzikhan, Natalie</au><au>Zhou, Xia</au><au>Booth, Sarah L.</au><au>Brusselle, Guy G.</au><au>de Boer, Ian H.</au><au>Fornage, Myriam</au><au>Frazier-Wood, Alexis C.</au><au>Graff, Mariaelisa</au><au>Gudnason, Vilmundur</au><au>Harris, Tamara B.</au><au>Hofman, Albert</au><au>Hou, Ruixue</au><au>Houston, Denise K.</au><au>Jacobs, David R.</au><au>Kritchevsky, Stephen B.</au><au>Latourelle, Jeanne</au><au>Lemaitre, Rozenn N.</au><au>Lutsey, Pamela L.</au><au>O’Connor, George</au><au>Oelsner, Elizabeth C.</au><au>Pankow, James S.</au><au>Psaty, Bruce M.</au><au>Rohde, Rebecca R.</au><au>Rich, Stephen S.</au><au>Rotter, Jerome I.</au><au>Smith, Lewis J.</au><au>Stricker, Bruno H.</au><au>Voruganti, V. Saroja</au><au>Wang, Thomas J.</au><au>Zillikens, M. Carola</au><au>Barr, R. Graham</au><au>Dupuis, Josée</au><au>Gharib, Sina A.</au><au>Lahousse, Lies</au><au>London, Stephanie J.</au><au>North, Kari E.</au><au>Smith, Albert V.</au><au>Steffen, Lyn M.</au><au>Hancock, Dana B.</au><au>Cassano, Patricia A.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2018-11-28</date><risdate>2018</risdate><volume>120</volume><issue>10</issue><spage>1159</spage><epage>1170</epage><pages>1159-1170</pages><issn>0007-1145</issn><issn>1475-2662</issn><eissn>1475-2662</eissn><abstract>The role that vitamin D plays in pulmonary function remains uncertain. Epidemiological studies reported mixed findings for serum 25-hydroxyvitamin D (25(OH)D)–pulmonary function association. We conducted the largest cross-sectional meta-analysis of the 25(OH)D–pulmonary function association to date, based on nine European ancestry (EA) cohorts (n 22 838) and five African ancestry (AA) cohorts (n 4290) in the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium. Data were analysed using linear models by cohort and ancestry. Effect modification by smoking status (current/former/never) was tested. Results were combined using fixed-effects meta-analysis. Mean serum 25(OH)D was 68 (sd 29) nmol/l for EA and 49 (sd 21) nmol/l for AA. For each 1 nmol/l higher 25(OH)D, forced expiratory volume in the 1st second (FEV1) was higher by 1·1 ml in EA (95 % CI 0·9, 1·3; P<0·0001) and 1·8 ml (95 % CI 1·1, 2·5; P<0·0001) in AA (P
race difference=0·06), and forced vital capacity (FVC) was higher by 1·3 ml in EA (95 % CI 1·0, 1·6; P<0·0001) and 1·5 ml (95 % CI 0·8, 2·3; P=0·0001) in AA (P
race difference=0·56). Among EA, the 25(OH)D–FVC association was stronger in smokers: per 1 nmol/l higher 25(OH)D, FVC was higher by 1·7 ml (95 % CI 1·1, 2·3) for current smokers and 1·7 ml (95 % CI 1·2, 2·1) for former smokers, compared with 0·8 ml (95 % CI 0·4, 1·2) for never smokers. In summary, the 25(OH)D associations with FEV1 and FVC were positive in both ancestries. In EA, a stronger association was observed for smokers compared with never smokers, which supports the importance of vitamin D in vulnerable populations.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>30205856</pmid><doi>10.1017/S0007114518002180</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0002-7232-0543</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0007-1145 |
| ispartof | British journal of nutrition, 2018-11, Vol.120 (10), p.1159-1170 |
| issn | 0007-1145 1475-2662 1475-2662 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_6263170 |
| source | Cambridge Journals Online; MEDLINE; Full-Text Journals in Chemistry (Open access); EZB Electronic Journals Library |
| subjects | 25-Hydroxyvitamin D Adult African Americans Aged Aging Airway management Atherosclerosis Black People Cancer Chronic obstructive pulmonary disease Consortia Cross-Sectional Studies Data processing Dietary Surveys and Nutritional Epidemiology Epidemiology Female Forced Expiratory Volume Genome, Human Heart Heart - physiology Heart Diseases - genetics Heart Diseases - prevention & control Humans Lung - physiology Lung Diseases - genetics Lung Diseases - prevention & control Male Males Medical screening Meta-analysis Middle Aged Molecular Epidemiology Prospective Studies Pulmonary functions Regression Analysis Respiratory function Respiratory Function Tests Smoking Vital Capacity Vitamin D Vitamin D - analogs & derivatives Vitamin D - blood White People Young adults |
| title | Meta-analysis across Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium provides evidence for an association of serum vitamin D with pulmonary function |
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