Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans

Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream e...

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Veröffentlicht in:Development (Cambridge) 2018-11, Vol.145 (22)
Hauptverfasser: Zheng, Chaogu, Jin, Felix Qiaochu, Trippe, Brian Loeber, Wu, Ji, Chalfie, Martin
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container_issue 22
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container_title Development (Cambridge)
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creator Zheng, Chaogu
Jin, Felix Qiaochu
Trippe, Brian Loeber
Wu, Ji
Chalfie, Martin
description Terminal differentiation generates the specialized features and functions that allow postmitotic cells to acquire their distinguishing characteristics. This process is thought to be controlled by transcription factors called 'terminal selectors' that directly activate a set of downstream effector genes. In , the differentiation of both the mechanosensory touch receptor neurons (TRNs) and the multidendritic nociceptor FLP neurons uses the terminal selectors UNC-86 and MEC-3. The FLP neurons fail to activate TRN genes, however, because a complex of two transcriptional repressors (EGL-44/EGL-46) prevents their expression. Here, we show that the ZEB family transcriptional factor ZAG-1 promotes TRN differentiation not by activating TRN genes but by preventing the expression of EGL-44/EGL-46. As EGL-44/EGL-46 also inhibits the production of ZAG-1, these proteins form a bistable, negative-feedback loop that regulates the choice between the two neuronal fates.
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subjects Animals
Base Sequence
Biomarkers - metabolism
Caenorhabditis elegans - cytology
Caenorhabditis elegans - genetics
Caenorhabditis elegans - metabolism
Caenorhabditis elegans Proteins - metabolism
Cell Differentiation
Cell Lineage
Gene Expression Regulation, Developmental
Models, Biological
Mutation - genetics
Neurons - cytology
Neurons - metabolism
Penetrance
Receptors, Cell Surface - metabolism
RNA Interference
Time Factors
Touch - physiology
Transcription Factors - metabolism
title Inhibition of cell fate repressors secures the differentiation of the touch receptor neurons of Caenorhabditis elegans
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