Real-Time Genetic Compensation Defines the Dynamic Demands of Feedback Control

Biological signaling networks use feedback control to dynamically adjust their operation in real time. Traditional static genetic methods such as gene knockouts or rescue experiments can often identify the existence of feedback interactions but are unable to determine what feedback dynamics are requ...

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Veröffentlicht in:	Cell 2018-10, Vol.175 (3), p.877-886.e10
Hauptverfasser:	Harrigan, Patrick, Madhani, Hiten D., El-Samad, Hana
Format:	Artikel
Sprache:	eng
Schlagworte:	closed-loop control computer software feedback Feedback, Physiological Gene Expression Regulation, Fungal Genetic Complementation Test - methods infrastructure Mating Factor - genetics Mating Factor - metabolism optogenetics Optogenetics - methods pheromones Saccharomyces cerevisiae - genetics Software transcription (genetics) Transcriptional Activation yeast mating pathway yeasts
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