Clinicopathological analysis of the hydroa vacciniforme-like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T-cell lymphoma
Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)-cell phenotype. The HVLPD-NK cell phenotype may be difficult to distinguish from cutaneo...
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| Veröffentlicht in: | Experimental and therapeutic medicine 2018-12, Vol.16 (6), p.4772-4778 |
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| creator | Wang, Guan-Nan Cui, Yong Zhao, Wu-Gan Li, Ling Zhang, Xu-Dong Chang, Yu Gao, Xian-Zheng Li, Ye Zhang, Ming-Zhi Li, Wen-Cai |
| description | Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)-cell phenotype. The HVLPD-NK cell phenotype may be difficult to distinguish from cutaneous natural killer T-cell lymphoma (CNKTL), as these two diseases share similar immunophenotypic markers. Therefore, the aim of the present study was to analyze the clinicopathological features of this rare disease and compare these features with those of CNKTL. The clinical, histopathological and molecular features of 5 patients with the HVLPD-NK cell phenotype and 11 patients with CNKTL were evaluated. As well as certain subtle histopathological differences, there marked differences the age, distribution of lesions and clinical course differed between patients with these two diseases. These results suggest that the HVLPD-NK cell phenotype should be classified as a separate disorder and treated accordingly. |
| doi_str_mv | 10.3892/etm.2018.6768 |
| format | Article |
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The HVLPD-NK cell phenotype may be difficult to distinguish from cutaneous natural killer T-cell lymphoma (CNKTL), as these two diseases share similar immunophenotypic markers. Therefore, the aim of the present study was to analyze the clinicopathological features of this rare disease and compare these features with those of CNKTL. The clinical, histopathological and molecular features of 5 patients with the HVLPD-NK cell phenotype and 11 patients with CNKTL were evaluated. As well as certain subtle histopathological differences, there marked differences the age, distribution of lesions and clinical course differed between patients with these two diseases. These results suggest that the HVLPD-NK cell phenotype should be classified as a separate disorder and treated accordingly.</description><identifier>ISSN: 1792-0981</identifier><identifier>EISSN: 1792-1015</identifier><identifier>DOI: 10.3892/etm.2018.6768</identifier><identifier>PMID: 30542432</identifier><language>eng</language><publisher>Greece: Spandidos Publications</publisher><subject>Age ; Classification ; Disease ; Females ; Fever ; Gangrene ; Genotype & phenotype ; Lymphatic diseases ; Lymphoma ; Lymphoproliferative disorders ; Medical diagnosis ; Medical prognosis ; Morphology ; Patients ; Phenotype ; Radiation therapy ; T cells</subject><ispartof>Experimental and therapeutic medicine, 2018-12, Vol.16 (6), p.4772-4778</ispartof><rights>COPYRIGHT 2018 Spandidos Publications</rights><rights>Copyright Spandidos Publications UK Ltd. 2018</rights><rights>Copyright © 2018, Spandidos Publications 2018</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c482t-24be5237f006b54b1fc51de07da2a6b6782d41ca79fae2fbab49f4f52b2b9e623</citedby><cites>FETCH-LOGICAL-c482t-24be5237f006b54b1fc51de07da2a6b6782d41ca79fae2fbab49f4f52b2b9e623</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257548/pdf/$$EPDF$$P50$$Gpubmedcentral$$H</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC6257548/$$EHTML$$P50$$Gpubmedcentral$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30542432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Guan-Nan</creatorcontrib><creatorcontrib>Cui, Yong</creatorcontrib><creatorcontrib>Zhao, Wu-Gan</creatorcontrib><creatorcontrib>Li, Ling</creatorcontrib><creatorcontrib>Zhang, Xu-Dong</creatorcontrib><creatorcontrib>Chang, Yu</creatorcontrib><creatorcontrib>Gao, Xian-Zheng</creatorcontrib><creatorcontrib>Li, Ye</creatorcontrib><creatorcontrib>Zhang, Ming-Zhi</creatorcontrib><creatorcontrib>Li, Wen-Cai</creatorcontrib><title>Clinicopathological analysis of the hydroa vacciniforme-like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T-cell lymphoma</title><title>Experimental and therapeutic medicine</title><addtitle>Exp Ther Med</addtitle><description>Hydroa vacciniforme-like lymphoproliferative disorder (HVLPD) is defined as a distinctive clinicopathological type of cutaneous lymphoma and a subset of patients with this disease exhibit the natural killer (NK)-cell phenotype. 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These results suggest that the HVLPD-NK cell phenotype should be classified as a separate disorder and treated accordingly.</description><subject>Age</subject><subject>Classification</subject><subject>Disease</subject><subject>Females</subject><subject>Fever</subject><subject>Gangrene</subject><subject>Genotype & phenotype</subject><subject>Lymphatic diseases</subject><subject>Lymphoma</subject><subject>Lymphoproliferative disorders</subject><subject>Medical diagnosis</subject><subject>Medical prognosis</subject><subject>Morphology</subject><subject>Patients</subject><subject>Phenotype</subject><subject>Radiation therapy</subject><subject>T cells</subject><issn>1792-0981</issn><issn>1792-1015</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNptkk1v3CAQhq2qVROlOfZaIfXSi7eAAduXStGqX1KkXtIzwnhYk2DjAt5of1f_YHF3mzZR4QCCZ95hmLcoXhO8qZqWvoc0bigmzUbUonlWnJO6pSXBhD8_7XHbkLPiMsZbnAcXpGn4y-KswpxRVtHz4ufW2clqP6s0eOd3ViuH1KTcIdqIvEFpADQc-uAV2iutM2x8GKF09g6QO4zz4OfgnTUQVLJ7QL2NPvQQ0L1NA5pUWkKWvLPO5TMNzqF5gMmnwwxI-3FWAfojq5ekJvBLfBp1U_6OO2Yb1avihVEuwuVpvSi-f_p4s_1SXn_7_HV7dV1q1tBUUtYBp1VtMBYdZx0xmpMecN0rqkQn6ob2jGhVt0YBNZ3qWGuY4bSjXQuCVhfFh6PuvHQj9BqmlB8l52BHFQ7SKysf30x2kDu_l4LymrMmC7w7CQT_Y4GY5GjjWsqxTEkJ5y2psBAZffsEvfVLyH1YKdYKyhpW_6V2yoG0k_E5r15F5RUXvK5yW3mmNv-h8uxhzK2ewNh8_iigPAbo4GMMYB5qJFiuRpPZaHI1mlyNlvk3_37MA_3HVtUv4JLURw</recordid><startdate>20181201</startdate><enddate>20181201</enddate><creator>Wang, Guan-Nan</creator><creator>Cui, Yong</creator><creator>Zhao, Wu-Gan</creator><creator>Li, Ling</creator><creator>Zhang, Xu-Dong</creator><creator>Chang, Yu</creator><creator>Gao, Xian-Zheng</creator><creator>Li, Ye</creator><creator>Zhang, Ming-Zhi</creator><creator>Li, Wen-Cai</creator><general>Spandidos Publications</general><general>Spandidos Publications UK Ltd</general><general>D.A. 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| source | PubMed Central |
| subjects | Age Classification Disease Females Fever Gangrene Genotype & phenotype Lymphatic diseases Lymphoma Lymphoproliferative disorders Medical diagnosis Medical prognosis Morphology Patients Phenotype Radiation therapy T cells |
| title | Clinicopathological analysis of the hydroa vacciniforme-like lymphoproliferative disorder with natural killer cell phenotype compared with cutaneous natural killer T-cell lymphoma |
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