Double-Blind, Randomized, Placebo-Controlled Phase II Dose-Finding Study To Evaluate High-Dose Rifampin for Tuberculous Meningitis

High doses of rifampin may help patients with tuberculous meningitis (TBM) to survive. Pharmacokinetic pharmacodynamic evaluations suggested that rifampin doses higher than 13 mg/kg given intravenously or 20 mg/kg given orally (as previously studied) are warranted to maximize treatment response. In...

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Veröffentlicht in:	Antimicrobial agents and chemotherapy 2018-12, Vol.62 (12)
Hauptverfasser:	Dian, S, Yunivita, V, Ganiem, A R, Pramaesya, T, Chaidir, L, Wahyudi, K, Achmad, T H, Colbers, A, Te Brake, L, van Crevel, R, Ruslami, R, Aarnoutse, R
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibiotics, Antitubercular Clinical Therapeutics Editor's Pick Mycobacterium tuberculosis Rifampin Tuberculosis, Meningeal
Online-Zugang:	Volltext
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