Stereoselective Synthesis of the Isomers of Notoincisol A: Assigment of the Absolute Configuration of this Natural Product and Biological Evaluation

The total syntheses of all stereoisomers of notoincisol A, a recently isolated natural product with potential anti-inflammatory activity, are reported. The asymmetric synthesis was conducted employing a lipase-mediated kinetic resolution, which enables easy access to all required chiral building blo...

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Veröffentlicht in:	Journal of natural products (Washington, D.C.) D.C.), 2018-11, Vol.81 (11), p.2419-2428
Hauptverfasser:	Rycek, Lukas, Ticli, Vincenzo, Pyszkowski, Jakob, Latkolik, Simone, Liu, Xin, Atanasov, Atanas G, Steinacher, Theresa, Bauer, Rudolf, Schuster, Daniela, Dirsch, Verena M, Schnürch, Michael, Ernst, Margot, Mihovilovic, Marko D
Format:	Artikel
Sprache:	eng
Schlagworte:	Allosteric Regulation anti-inflammatory activity Biological Products - chemistry Biological Products - pharmacology computer simulation gamma-aminobutyric acid HEK293 Cells Humans inflammation ion channels Molecular Docking Simulation Molecular Structure optical properties peroxisome proliferator-activated receptor gamma Polyynes - chemistry Polyynes - pharmacology PPAR gamma - metabolism Stereoisomerism stereoisomers stereoselective synthesis
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